Results 51 to 60 of about 782,946 (316)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Assessing the Economic Benefit of Mass COVID-19 Vaccination Program in Iran: A Real-World Modeling Study [PDF]

International Journal of Health Policy and Management
Background  The global challenges posed by COVID-19 vaccinations require careful consideration by decision-makers at both the global and national levels, particularly in developing countries.
Hamidreza Jamaati, Saeed Karimi, Yunes Panahi, Shahnam Arshi, Maryam Hajimoradi, Fatemeh Sadat Hosseini-Baharanchi, Fariba Ghorbani, Seyed Mohsen Zahraei, Fatemeh Nouri, Ali Akbari Sari, Mahshad Goharimehr, Abdolreza Mohamadnia, Payam Tabarsi, Farzaneh Dastan, Babak Sharif-Kashani, Majid Marjani, Farin Rashid Farokhi, Seyed Mohammad Reza Hashemian, Mostafa Noorizadeh, Mojtaba Nouhi, Katayoun Tayeri, Sima Noorali, Farnaz Ahmadi, Makan Sadr, Azadeh Moradkhani, Mahdi Ahmadinia, Bahamin Astani, Rajabali Daroudi, Shadi Shafaghi   +28 more
doaj   +1 more source

Prediction of multidrug-resistant tuberculosis in tuberculosis patients using perceptron artificial neural networks model [PDF]

Health Science Monitor, 2023
Background & Aims: Diagnosis and treatment of patients with multidrug-resistant tuberculosis (MDR-TB) are very important. Hence, it is necessary to predict and diagnose these patients based on individual, demographic and clinical characteristics before ...
Mehdi Kazempour Dizaji, Mohammad Varahram, Payam Tabarsi, Rahim Roozbahani, Ali Zare, Afshin Moniri, Mohammadreza Madani, Atefe Abedini, Parvaneh Baghaei Shiva, Majid Marjani, Niloufar Alizadeh Kolahdozi   +10 more
doaj  

The natural history of chronic obstructive pulmonary disease [PDF]

, 2006
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality in the USA, and it remains one of the few diseases that continues to increase its numbers.
Mapel, D. W., Hawthorne, V, Heart, C, Vestbo, J., Mapel, D.W., Man, S. F P, Vestbo, J.; id_orcid, Man, SFP, Watt, G., Hart, C., Gillis, C., Mannino, D. M., Smith, G. Davey, Hawthorne, V., Upton, MN, Hart, C, Sin, D. D., Sin, DD, Van Eden, S., Davey Smith, G, Gillis, C, Upton, M, McConnachie, A., Man, S.F.P., Van Eeden, S., McConnachie, A, Hole, D., Mannino, DM, Mapel, DW, Sinn, DD, Sin, D.D., Van Eeden, S, Vestbo, J, Watt, G, Vestbo, Jørgen, Upton, M., Davey Smith, G., Hole, D, Mannino, D.M.   +38 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Construction of China cardiovascular health index

BMC Public Health, 2018
Background Cardiovascular disease (CVD) is not only the primary cause of death in developed western countries, but also its disease burden is increasing in China.
Yingying Jiang, Fan Mao, Yichong Li, Jing Liu, Yan Zhang, Yong Jiang, Dong Zhao, Weiwei Chen, Stephen Nicholas, Yong Huo, Junbo Ge, Linhong Wang, Maigeng Zhou   +12 more
doaj   +1 more source

Neonatal chronic lung disease

Jornal de Pediatria, 1998
OBJECTIVE: The author presents a review about neonatal chronic lung disease, with particular emphasis on pathophysiology and outpatient follow up. METHODS: The most relevant articles concerning the disorder were selected through Medline search, from the initial description of the disease, in 1967.RESULTS: Neonatal chronic lung disease is a condition ...
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Changing patterns in long-acting bronchodilator trials in chronic obstructive pulmonary disease.

, 2011
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Developments in the understanding of COPD have led to standard guidelines for diagnosis, treatment, and spirometry assessments, which have in turn ...
James Donohue, Paul Jones, James F Donohue, Paul W Jones, Donohue, JF, Jones, PW   +5 more
core   +1 more source

The association between blood coagulation activity and lung function: a population-based study [PDF]

, 2010
<p><b>Background:</b> Increased in susceptibility to thrombotic disease may be associated with lower lung function. If causal, this association may suggest an area for development of new interventions for lung disease.
Lowe, G.D.O., Lorna Clark, Clark, L., Sarah A Lewis, Andrew W Fogarty, Tricia M McKeever, John Britton, Fogarty, A.W., Lewis, S.A., Gordon D O Lowe, Britton, J., Sarah A. Lewis, McKeever, T.M., Gordon D. O. Lowe, Tricia M. McKeever, Reitsma, P.H., Andrew W. Fogarty   +16 more
core   +1 more source