Results 51 to 60 of about 7,142,424 (292)

Influence of lung function on course of disease and response to antibiotic therapy in adult primary care patients with acute cough: a post hoc analysis of patients enrolled in a prospective multicentre study [PDF]

, 2014
BACKGROUND: In acute cough patients, impaired lung function as present in chronic lung conditions like asthma and chronic obstructive pulmonary disease (COPD) are often thought to negatively influence course of disease, but clear evidence is lacking.AIMS:
Verheij, Theo J M, Leven, Margareta, Moore, Michael, Verheij, TJ, Thomas, Mike, Verheij, Theo J.M., Stuart, B, Hood, K, Coenen, Samuel, Stuart, Beth, Goossens, Herman, Goossens, H, Little, Paul, Moore, M, Coenen, S, Little, P, van Erp, Nicole, Thomas, M, Hood, Kerenza, van Erp, N, Butler, Chris C., Butler, CC, Leven, M   +22 more
core   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Assessing the Economic Benefit of Mass COVID-19 Vaccination Program in Iran: A Real-World Modeling Study [PDF]

International Journal of Health Policy and Management
Background  The global challenges posed by COVID-19 vaccinations require careful consideration by decision-makers at both the global and national levels, particularly in developing countries.
Hamidreza Jamaati, Saeed Karimi, Yunes Panahi, Shahnam Arshi, Maryam Hajimoradi, Fatemeh Sadat Hosseini-Baharanchi, Fariba Ghorbani, Seyed Mohsen Zahraei, Fatemeh Nouri, Ali Akbari Sari, Mahshad Goharimehr, Abdolreza Mohamadnia, Payam Tabarsi, Farzaneh Dastan, Babak Sharif-Kashani, Majid Marjani, Farin Rashid Farokhi, Seyed Mohammad Reza Hashemian, Mostafa Noorizadeh, Mojtaba Nouhi, Katayoun Tayeri, Sima Noorali, Farnaz Ahmadi, Makan Sadr, Azadeh Moradkhani, Mahdi Ahmadinia, Bahamin Astani, Rajabali Daroudi, Shadi Shafaghi   +28 more
doaj   +1 more source

Prediction of multidrug-resistant tuberculosis in tuberculosis patients using perceptron artificial neural networks model [PDF]

Health Science Monitor, 2023
Background & Aims: Diagnosis and treatment of patients with multidrug-resistant tuberculosis (MDR-TB) are very important. Hence, it is necessary to predict and diagnose these patients based on individual, demographic and clinical characteristics before ...
Mehdi Kazempour Dizaji, Mohammad Varahram, Payam Tabarsi, Rahim Roozbahani, Ali Zare, Afshin Moniri, Mohammadreza Madani, Atefe Abedini, Parvaneh Baghaei Shiva, Majid Marjani, Niloufar Alizadeh Kolahdozi   +10 more
doaj  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Construction of China cardiovascular health index

BMC Public Health, 2018
Background Cardiovascular disease (CVD) is not only the primary cause of death in developed western countries, but also its disease burden is increasing in China.
Yingying Jiang, Fan Mao, Yichong Li, Jing Liu, Yan Zhang, Yong Jiang, Dong Zhao, Weiwei Chen, Stephen Nicholas, Yong Huo, Junbo Ge, Linhong Wang, Maigeng Zhou   +12 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Pulmonary Hypertension in Chronic Lung Diseases

Journal of the American College of Cardiology, 2013
Chronic obstructive lung disease (COPD) and diffuse parenchymal lung diseases (DPLD), including idiopathic pulmonary fibrosis (IPF) and sarcoidosis, are associated with a high incidence of pulmonary hypertension (PH), which is linked with exercise limitation and a worse prognosis.
Seeger, Werner, Adir, Yochai, Albert Barbera, Joan, Champion, Hunter, Coghlan, John Gerard, Cottin, Vincent, de Marco, Teresa, Galiè, Nazzareno, Ghio, Stefano, Gibbs, Simon, Martinez, Fernando J., Semigran, Marc J., Simonneau, Gérald, Wells, Athol U., Vachiery, Jean-Luc   +14 more
openaire   +6 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source