Results 111 to 120 of about 1,722,968 (253)

Significantly shorter telomeres in T-cells of patients with ZAP-70+/CD38+ chronic lymphocytic leukaemia

, 2008
In contrast to other B-cell neoplasias, chronic lymphocytic leukaemia (CLL) is characterized by increased non-leukaemic T-cells. In order to assess their replicative history, telomere length was analyzed in subsets of leucocytes from CLL patients.
Sellmann, Ludger, Nückel, Holger, Röth, Alexander, Dürig, Jan, Dührsen, Ulrich, de Beer, Dirk, Baerlocher, Gabriela M   +6 more
core   +1 more source

Cardiovascular toxicity induced by TKIs in patients with chronic myeloid leukaemia: Are women and men different?

ESC Heart Failure, Volume 12, Issue 2, Page 1447-1454, April 2025.
This study analyzes 148 patients (66 women and 82 men) with chronic myeloid leukemia treated with tyrosine kinase inhibitors, focusing on cardiovascular adverse events. The risk assessment, performed using the HFA/ICOS score, reveals sex‐specific differences: venous thrombosis is more common in women, while arterial thrombosis predominates in men.
Cristina Madaudo, Daniela Di Lisi, Antonio Cannatà, Federica Manfrè, Celeste Vullo, Marco Santoro, Ciro Botta, Salvatrice Mancuso, Sergio Siragusa, Alfredo Ruggero Galassi, Giuseppina Novo   +10 more
wiley   +1 more source

Interferon Alfa in the treatment of B-cell chronic lymphocytic leukemia [PDF]

, 1994
Knauf, W. U., Maubach, P. A., Adolf, D., Mitrou, P. S., Emmerich, B., Ziegle-Heitbrock, H. W. L., Thiel, E., Langenmayer, Irmgard, Bergmann, L., Dietzfelbinger, H., Nerl, C.   +10 more
core   +1 more source

Expansion of CD4+ T cells with a cytotoxic phenotype in patients with B-chronic lymphocytic leukaemia (B-CLL)

, 2001
Abnormal CD4/CD8 ratios and T-cell function have previously been shown in patients with B-chronic lymphocytic leukaemia (B-CLL). We have demonstrated that CD4+ T cells containing both serine esterase and perforin (PF) are increased in the blood of these ...
Roschupkina, T., Patterson, K., Jewell, A.P., Yong, K., Yong, K.L., Lydyard, P.M., Porakishvili, N., Kalber, T.   +7 more
core   +1 more source

Risk of Developing Subsequent Primary Colorectal Cancers Among Non‐Colorectal Cancer Survivors: Implications for Prevention and Screening

International Journal of Cancer, EarlyView.
ABSTRACT Cancer survivors have an elevated risk of developing subsequent primary cancers, including colorectal cancer (CRC), and may benefit from tailored screening approaches to reduce incidence and morbidity. A retrospective cohort of adults diagnosed with cancer (excluding CRC) in Alberta, Canada from 2000 to 2021 who survived at least 6 months was ...
Dylan E. O'Sullivan, Robert J. Hilsden, Hannah Harsanyi, Matthew T. Warkentin, Kareem Jamani, Huiming Yang, Darren R. Brenner, Safiya Karim, Winson Y. Cheung, Yibing Ruan   +9 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Interferon-alpha 2b early phase chronic Lymphocytic Leukemia with high risk for progression-first results of a randomized multicenter AIO-Study [PDF]

, 1992
Knauf, W. U., Ziegler-Heitbrock, H. W., Emmerich, B., Thiel, E., Langenmayer, Irmgard, Mausbach, P., Dietzfelbinger, H., Nerl, C.   +7 more
core   +1 more source

Management of chronic lymphocytic leukaemia

, 2011
Chronic lymphocytic leukaemia is a disease that primarily affects the elderly and has a heterogeneous clinical course. The past decade has witnessed extensive progress in its management, owing to the generation of prognostic biological markers that ...
Tse, E, Singh Gill, H
core  

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Notch1 is induce by p53 as a possible anti-apoptotic mechanism in Chronic Lymphocytic Leukemia

, 2023
openNotch1 is induce by p53 as a possible anti-apoptotic mechanism in Chronic Lymphocytic ...
ZADRO, ALEX
core