Results 191 to 200 of about 1,722,968 (253)

Epidemiology of chronic lymphocytic leukaemia in Germany: A retrospective analysis of administrative claims data. [PDF]

Ann Hematol
Maqhuzu PN, Bocuk D, Boelz S, Hosseini SK, Leeb C, Renevey F, Mevius A, Greth K, Christofyllakis K.   +8 more
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

A pilot randomized trial of supervised resistance training plus home-based activity in chronic lymphocytic leukaemia patients. [PDF]

Sci Rep
Sánchez-González JL, Fernández-Rodríguez EJ, Méndez-Sánchez R, Polo-Ferrero L, Puente-González S, de Ramón C, Marcos-Asensio S, Blázquez-Benito P, Baile-González M, Navarro-Bailón A, Sánchez-Guijo F, Martín-Vallejo J, Perez J, Martín-Sánchez C.   +13 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

SOX4 in chronic lymphocytic leukaemia: the forgotten transcription factor. [PDF]

Blood Res
García-Muñoz R, Alberdi-Ballina J, Farfan-Quiroga G, Robles EF, Larráyoz MJ, Calasanz MJ, Martínez-Climent JÁ, Panizo C, Larreina-Pérez J, Rincón-López S, Atencio-Matos J, Campeny-Najara A, Esteban-Figuerola A, Hernandez-Perez M, Garrastachu-Zumaran P, Velasco-Ruiz M, de Gaona ER, Feliu J.   +17 more
europepmc   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

The ethics of a watch-and-wait diagnosis: an exploratory study on the experiences of patients with stage A chronic lymphocytic leukaemia. [PDF]

BMC Med Ethics
Tinland J, Haddadi O, Dann MA.
europepmc   +1 more source

Thermodynamic characterisation of covalent ligand binding

British Journal of Pharmacology, EarlyView.
Background and Purpose Differential scanning fluorimetry (DSF) is a common and straightforward method to evaluate the thermal stability of proteins and has been heavily used for ligand binding characterisation as well as for screening. One class of compounds that is less typically evaluated by DSF are covalent binders.
Rebecca Hertzman, Maayan Lavie, Almog Nadir, Ronen Gabizon, Nir London   +4 more
wiley   +1 more source

Efficacy and safety analysis of the use of ibrutinib associated with rituximab for the first-line treatment of patients with chronic lymphocytic leukaemia. [PDF]

Hematol Transfus Cell Ther
Nascimento AD, Curado DDSP, Montezuma T, Barbosa WB, Machado-Rugolo J, Fachi MM.   +5 more
europepmc   +1 more source

Pirtobrutinib in Richter syndrome: Outcomes from the named patient programme in Italy

British Journal of Haematology, EarlyView.
Isacco Ferrarini, Daniela Estefania Banegas, Andrea Bernardelli, Alessia Moioli, Francesca Maria Quaglia, Ester Lovato, Anna Maria Frustaci, Massimiliano Postorino, Davide Facchinelli, Monica Tani, Francesca Cibien, Chandrakala Toldo, Elisa Lucchini, Roberto Marasca, Marzia Varettoni, Chiara Rusconi, Lucia Farina, Andrea Visentin, Riccardo Moia, Carlo Visco   +19 more
wiley   +1 more source