Results 91 to 100 of about 92,728 (309)
MicroRNAs in chronic lymphocytic leukemia
Experimental and Molecular Pathology, 2011 Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world. Recent research, conducted primarily in basic science laboratories, has indicated a role for microRNAs (miRNAs) in the pathogenesis and prognosis of this disease. MiRNAs are small, non-coding, functional RNAs, that mediate post-transcriptional inhibition of messenger ...
Brian P, Ward +2 more
openaire +2 more sources
The expanding role of bendamustine in chronic lymphocytic leukemia
, 2015 Kruti Sheth Nair, Chaitra Ujjani Lombardi Comprehensive Cancer Center, Medstar Georgetown University Hospital, Washington, DC, USA Abstract: As the most prevalent form of adult leukemia, chronic lymphocytic leukemia (CLL) affects thousands of patients ...
Nair KS, Ujjani C
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Report of Public Meeting to Seek Input on Gaps in Chronic Lymphocytic Leukemia (CLL) Radiogenicity Research held July 21, 2004 [PDF]
"Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the Western world. While the etiology of CLL is largely unknown, it is currently the only cancer assigned a probability of causation by ionizing radiation of zero under the US ...
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British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
Haematologica, 2010 Background The aims of the present study were to ascertain the activation status of Akt in the primary cells of chronic lymphocytic leukemia and to investigate the effects of specific Akt inhibition on chronic lymphocytic leukemia-cell survival.Design ...
Jianguo Zhuang +7 more
doaj +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
Haematologica, 2009 Background Programmed cell death has been traditionally related with caspase activation. However, it is now accepted that caspase-independent forms of programmed cell death also regulate cell death.
Sandrine Barbier +12 more
doaj +1 more source
Meningeal Leukemia Complicating Chronic Lymphocytic Leukemia
, 1981 Two patients with classic chronic lymphocytic leukemia had meningeal leukemia as a complication of their disease. Intrathecal chemotherapy was successful in eradicating signs and symptoms of meningeal involvement.
Votaw, May L., Liepman, Marcia K.
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Biotechnology and Bioengineering, EarlyView.ABSTRACT The detergent Triton X‐100 (TX‐100) is a typical component of solvent/detergent (S/D) mixes applied for virus inactivation steps of biomanufacturing processes, yet environmentally unfavorable properties have led to restrictions on its use. Deviron 13‐S9 has recently been described as an eco‐friendly TX‐100 alternative, with powerful virus ...
Johanna Kindermann +3 more
wiley +1 more source