Results 71 to 80 of about 92,728 (309)
Clinically Relevant Bleeding in Individuals With Cancer: Insights From a Nationwide Cohort Study
American Journal of Hematology, EarlyView.ABSTRACT
Cancer care is often complicated by coagulopathy leading to thrombosis and bleeding. While venous thromboembolism (VTE) has been extensively studied, bleeding remains an underestimated threat. To address this knowledge gap, we leveraged the Epic Cosmos database to determine the impact of cancer‐associated clinically relevant bleeding (CRB) in ...Ming Y. Lim, Radhika Gangaraju, Omid Jafari, Zihan Yang, Joyce W. T. Tiong, Elizabeth C. L. Chiang, Shengling Ma, Jun Y. Jiang, Justine Ryu, Barbara D. Lam, Mrinal Ranjan, Ang Li +11 morewiley +1 more sourceClinical and Laboratory Characterization of Acquired Von Willebrand Syndrome
American Journal of Hematology, EarlyView.ABSTRACT
Acquired von Willebrand Syndrome (AVWS) is a rare bleeding disorder characterized by quantitative or qualitative defects of von Willebrand factor (VWF) in patients without a personal or family history of bleeding. It is frequently associated with systemic diseases, particularly lymphoproliferative disorders (LPDs) and myeloproliferative ...Alessandro Ciavarella, Luciano Baronciani, Omid Seidizadeh, Paola Colpani, Elio Ingenito, Daniele Cattaneo, Maria Teresa Pagliari, Addolorata Truma, Alessandra Iurlo, Simona Maria Siboni, Flora Peyvandi +10 morewiley +1 more sourceHighly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations
Haematologica, 2018 Despite the recent discovery of recurrent driver mutations in chronic lymphocytic leukemia, the genetic factors involved in disease onset remain largely unknown.Andreas Agathangelidis, Viktor Ljungström, Lydia Scarfò, Claudia Fazi, Maria Gounari, Tatjana Pandzic, Lesley-Ann Sutton, Kostas Stamatopoulos, Giovanni Tonon, Richard Rosenquist, Paolo Ghia +10 moredoaj +1 more sourceZebrafish and CRISPR—A synergistic approach to decipher and cure human diseases
Animal Models and Experimental Medicine, EarlyView.Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty +4 morewiley +1 more sourceCommon variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia risk. [PDF]
, 2014 Common variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia ...Di Bernardo, M. C., Hall, A G, L. Karabon (13679), D J Allsup (16263350), Fegan, C., A Holroyd (7780811), Mansouri, Larry,, Summerfield, G, H Marr, Juliusson, G, D Catovsky (7780913), T Mainou-Fowler (7673420), Majid, A, Woszczyk, D, Pepper, C, Mainou-Fowler, T., A Holroyd, K Jamroziak, Mansouri, L, Karabon, L., R S Houlston (16263359), I Frydecka, A. Holroyd (7673381), C. Pepper (7673438), Karabon, L, Dearden, C., A. R. Pettitt (7638851), R Rosenquist, Catovsky, D, C. Fegan (7603403), Sava, G. P., Jayne, S., Majid, A., Mainou-Fowler, T, Fegan, C, R Rosenquist (7780847), I. Frydecka (7673393), G Juliusson, S Jayne (7719818), G Pratt, K. Jamroziak (7673396), G. Pratt (7603379), I Frydecka (16263323), R. Rosenquist (7652192), Wang, Y., Martin J. S. Dyer (7583432), G Juliusson (7780829), Lund University., D. Woszczyk (7673399), Juliusson, Gunnar, Y Wang, C Dearden, J R Bailey, C Pepper, G Summerfield, Jackson, G H, Pettitt, A. R., A Majid, G. Summerfield (7673426), L Karabon, T Mainou-Fowler, Bailey, J. R., Allan, J. M., M C Di Bernardo, Juliusson, Gunnar,, A G Hall, L Karabon (16263320), Juliusson, G., Speedy, H. E., Frydecka, I., H E Speedy (16263305), S Deaglio (13612099), A G Hall (16263335), Dyer, M J S, S. Deaglios (7673390), K Jamroziak (16263326), Wang, Y, Deaglio, S., Catovsky, D., A. G. Hall (7673417), G Summerfield (16263341), Sava, G P, R S Houlston, G H Jackson (16263338), Deaglio, S, D Woszczyk (16263329), A R Pettitt, Summerfield, G., Smedby, K E, Bailey, J R, C Dearden (7780835), L Mansouri, G H Jackson, K E Smedby, M C Di Bernardo (16263308), S Deaglio, G Pratt (7780844), Speedy, H E, L. Mansouri (7652165), Dyer, M. J.S., G P Sava (16263302), D Woszczyk, J M Allan, Y. Wang (473169), Allsup, D J, Jayne, S, N J Sunter, A. Majid (7673411), Sunter, N. J., J. M. Allan (7646246), J M Allan (16263356), Marr, H., H. E. Speedy (7673375), Hall, A. G., S. Jayne (7673408), Holroyd, A, Holroyd, A., C Fegan, Marr, H, Rosenquist, Richard Brandell,, H. Marr (7673387), Dyer, M. J. S., Allsup, D. J., Allan, J M, G. H. Jackson (7673423), Pettitt, A R, N. J. Sunter (7673384), S Jayne, H Marr (16263317), Christopher Pepper (4467913), Sunter, N J, Jamroziak, K., G. Juliusson (7673402), Pratt, G., Pratt, G, A R Pettitt (16263347), J R Bailey (16263353), L Mansouri (7780826), Y Wang (774825), D. Catovsky (7673441), D Catovsky, R J Harris (16263344), Jamroziak, K, Di Bernardo, M C, Rosenquist, R., K. E. Smedby (7673405), G P Sava, Mansouri, L., M J S Dyer, M. C. Di Bernardo (7673378), C Fegan (7760402), A Majid (7780832), M J S Dyer (16263311), D J Allsup, Woszczyk, D., Pepper, C., Harris, R. J., Rosenquist, R, Houlston, R. S., N J Sunter (16263314), Harris, R J, Frydecka, I, D. J. Allsup (7673432), Smedby, K. E., H E Speedy, R. S. Houlston (7646258), Dearden, C, J. R. Bailey (7673435), C. Dearden (7673414), K E Smedby (16263332), Jackson, G. H., R J Harris, R. J. Harris (7673429), G. P. Sava (7673372), Houlston, R S +174 morecore +1 more sourceUSB1 deficiency disrupts neutrophil maturation via RNA dysregulation independent of global pre‐mRNA splicing
Animal Models and Experimental Medicine, EarlyView.This graphical abstract illustrates the essential role of USB1 in neutrophil maturation. In normal myeloid cells, USB1 acts as an RNA exonuclease, trimming RNA tails to maintain proper RNA network function, which supports the differentiation of myeloid progenitor cells into mature neutrophils.Hang Li, Guiying Shi, Jiaming Tang, Yiying Huang, Jie Wang, Xuepei Lei, Lin Bai +6 morewiley +1 more sourceRole of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells
Haematologica, 2010 Background Bortezomib has been successfully used in the treatment of multiple myeloma and has been proposed as a potential treatment for chronic lymphocytic leukemia.Maria Baou, Susan L. Kohlhaas, Michael Butterworth, Meike Vogler, David Dinsdale, Renata Walewska, Aneela Majid, Eric Eldering, Martin J.S. Dyer, Gerald M. Cohen +9 moredoaj +1 more sourceImmunoglobulin Gene Analysis in Chronic Lymphocytic Leukemia
, 2018 The formation of B-cell receptor immunoglobulin (BcR IG) is the result of a multi-step process that starts at the pro-B cell stage with the VDJ gene recombination of IG genes of the heavy chain, followed by VJ recombination of the light chain genes at ...Hadzidimitriou, Anastasia, Stamatopoulos, Kostas, Chrysoula Belessi, Ghia, P, Agathangelidis, Andreas, Rosenquist, R, Belessi, C, Agathangelidis, A, Stamatopoulos, K,, Paolo Ghia, Rosenquist, Richard, Hadzidimitriou, A, Richard Rosenquist, Davi, Frederic, Andreas Agathangelidis, Anastasia Hadzidimitriou, Kostas Stamatopoulos, Ghia, Paolo, Belessi, Chrysoula, Frederic Davi, Davi, F +20 morecore +1 more sourceHumanized immune system animal models and their recent applications
Animal Models and Experimental Medicine, EarlyView.In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade +6 morewiley +1 more source
