Results 61 to 70 of about 92,728 (309)

Comparison of microRNA expression in high-count monoclonal B-cell lymphocytosis and Binet A chronic lymphocytic leukemia

Revista Brasileira de Hematologia e Hemoterapia
Background Evidence suggests that monoclonal B-cell lymphocytosis precedes all chronic lymphocytic leukemia cases, although the molecular mechanisms responsible for disease progression are not understood.
Felipe Magalhães Furtado, Priscila Santos Scheucher, Bárbara Amélia Santana, Dalila Lucíola Zanette, Rodrigo do Tocantins Calado, Eduardo Magalhães Rego, Daniel Mazza Matos, Roberto Passetto Falcão   +7 more
doaj   +1 more source

Cranial aspergillosis in a patient receiving ibrutinib for chronic lymphocytic leukemia

Medical Mycology Case Reports, 2019
Cerebral abscess due to Aspergillus species is a relatively uncommon presentation, even amongst immunocompromised patients. However it is increasingly being recognized as a complication of ibrutinib therapy in patients with chronic lymphocytic leukemia ...
Rohan Beresford, Virginia Dolot, Hong Foo   +2 more
doaj   +1 more source

Ofatumumab – a valid treatment option for chronic lymphocytic leukemia patients

, 2017
Salma M AlDallal Haematology Laboratory, Amiri Hospital, Kuwait City, Kuwait Abstract: Ofatumumab Arzerra® is a human monoclonal antibody, which induces killing of a panel of tumor B-cell lines and primary tumor cells by the activation of in vitro ...
AlDallal SM, Salma Al Dallal
core   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments

Haematologica, 2012
Background Interactions with the microenvironment, such as bone marrow mesenchymal stromal cells and nurse-like cells, protect chronic lymphocytic leukemia cells from spontaneous and drug-induced apoptosis.
Basile Stamatopoulos, Nathalie Meuleman, Cécile De Bruyn, Karlien Pieters, Philippe Mineur, Christine Le Roy, Stéphane Saint-Georges, Nadine Varin-Blank, Florence Cymbalista, Dominique Bron, Laurence Lagneaux   +10 more
doaj   +1 more source

MGA, a suppressor of MYC, is recurrently inactivated in high risk chronic lymphocytic leukemia

, 2012
Although modern treatment strategies are highly eff ective in many cases of progressive chronic lymphocytic leukemia (CLL), a challenging subgroup of patients show poor response to standard regimens and a survival of less than 2 years [1].
Martini M, Cresta S, De Paoli L, Bertoni F, Cerri, Michaela, Spina V, Monti S., Ciardullo, Carmela, Cresta, Stefania, Bruscaggin A., Famà R, Ciardullo C., Greco, Mariangela, Maffei R, Cerri M., Ladetto, Marco, Rasi S., Cresta S., Rasi S, Ciardullo C, Ladetto M., Spina, Valeria, De Paoli L., Marasca, Roberto, Bruscaggin A, Laurenti L, Spina V., Martini M., Monti S, Martini, Maurizio, Forconi F., Greco M., Larocca L. M., Cerri M, Ladetto M, Rasi, Silvia, Gaidano G., Rossi D., Gaidano, Gianluca, Marasca R., De Paoli, Lorenzo, Rossi, Davide, Monti, Sara, Bruscaggin, Alessio, Laurenti L., Maffei, Rossana, Laurenti, Luca, Maffei R., Larocca, Luigi M., FAMA', ROSELLA, Larocca, Luigi Maria, Bertoni, Francesco, Famà R., Forconi F, Famà, Rosella, Bertoni F., Greco M, Larocca LM, Marasca R, SPINA, Valeria Romina, Forconi, Francesco, Gaidano G   +61 more
core   +1 more source

Late Cytomegalovirus Infections After Allogeneic Hematopoietic Cell Transplant

American Journal of Hematology, EarlyView.
ABSTRACT Graft versus host disease (GVHD) prophylaxis with posttransplant cyclophosphamide (ptCY) and cytomegalovirus (CMV) prophylaxis with letermovir have changed the clinical epidemiology of CMV infection. We studied the incidence, risk factors for, and outcomes of CMV infection after Day + 90 of allogeneic hematopoietic cell transplant (alloHCT ...
George L. Chen, Roland Bassett, Rohtesh S. Mehta, Betul Oran, Fareed Khawaja, Ella J. Ariza‐Heredia, Yosra Aljawai, Amanda Olson, May Daher, Portia Smallbone, Katayoun Rezvani, Partow Kebriaei, Uday Popat, Richard Champlin, Roy F. Chemaly, Elizabeth J. Shpall   +15 more
wiley   +1 more source

Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia (“accelerated” chronic lymphocytic leukemia) with aggressive clinical behavior

Haematologica, 2010
Background The concept of “accelerated” chronic lymphocytic leukemia is frequently used by both pathologists and clinicians. However, neither histological criteria to define this form of chronic lymphocytic leukemia nor its clinical correlates and ...
Eva Giné, Antoni Martinez, Neus Villamor, Armando López-Guillermo, Mireia Camos, Daniel Martinez, Jordi Esteve, Xavier Calvo, Ana Muntañola, Pau Abrisqueta, Maria Rozman, Ciril Rozman, Francesc Bosch, Elias Campo, Emili Montserrat   +14 more
doaj   +1 more source

Epigenetics and chronic lymphocytic leukemia [PDF]

American Journal of Hematology, 2006
The DNA methylation level in patients with chronic lymphocytic leukemia is generally lower than healthy individuals. Although DNA methylation is globally decreased, regional hypermethylation of gene promoters leads to gene silencing. Many of these genes have tumor suppressor phenotypes.
openaire   +2 more sources

Extended lymphadenectomy for high-risk prostate cancer in patients with chronic lymphocytic leukemia may not be necessary: a report of two cases

BMC Cancer, 2019
Background Chronic lymphocytic leukemia is a malignancy with good prognosis. However, the incidence of secondary tumors increases every year after the diagnosis of chronic lymphotcytic leukemia. One of the induced secondary tumors is prostate cancer. For
Yinjie Zhu, Yanqing Wang, Zhiyu Qian, Jiahua Pan, Qiang Liu, Baijun Dong, Wei Xue   +6 more
doaj   +1 more source