Results 101 to 110 of about 1,913,070 (304)

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source

The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax

Haematologica, 2017
Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins. In the study herein, the pro-apoptotic effect of fluorizoline was assessed in 34 primary samples from patients with chronic lymphocytic leukemia ...
Ana M. Cosialls, Helena Pomares, Daniel Iglesias-Serret, José Saura-Esteller, Sonia Núñez-Vázquez, Diana M. González-Gironès, Esmeralda de la Banda, Sara Preciado, Fernando Albericio, Rodolfo Lavilla, Gabriel Pons, Eva M. González-Barca, Joan Gil   +12 more
doaj   +1 more source

PD-1 positive NK cell population is higher in patients with chronic lymphocytic leukaemia and contributes to the impaired function of NK cells

, 2017
International Workshop on Chronic Lymphocytic Leukemia (17th. 2017.
Zuo, Jianmin, Parry, Helen, Pratt, Guy, Moss, Paul, Villa Álvarez, Mónica   +4 more
core  

Obinutuzumab treatment in the elderly patient with chronic lymphocytic leukemia [PDF]

, 2015
Karen Seiter, Aleksandra Mamorska-DygaDepartment of Medicine, Division of Hematology/Oncology, New York Medical College, Valhalla, NY, USA Abstract: Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries ...
Seiter K, Mamorska-Dyga A
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Generation of Functional CLL-Specific Cord Blood CTL Using CD40-Ligated CLL APC [PDF]

, 2012
PMCID: PMC3526610This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
John G. Gribben, Xing, D, Halpert Matthew M., Shpall, EJ, John G Gribben, Keating Michael J., Yang, H, Hong Yang, Halpert, MM, Elizabeth J Shpall, William K. Decker, Elizabeth J. Shpall, Li Sufang, Gribben John G., Michael J. Keating, Molldrem Jeffrey J., Lapushin Ruth, Lapushin, R, Xing Dongxia, Parmar Simrit, Robinson Simon N., Parmar, S, Simrit Parmar, Shpall Elizabeth J., Yang Hong, William K Decker, Wierda, WG, Shah Nina, Shah, N, William G Wierda, Gribben, JG, Sufang Li, Dongxia Xing, Matthew M Halpert, Jeffrey J Molldrem, Simon N. Robinson, Simon N Robinson, William G. Wierda, Michael J Keating, Matthew M. Halpert, Robinson, SN, Molldrem, JJ, Decker William K., Keating, MJ, Ruth Lapushin, Jeffrey J. Molldrem, Decker, WK, Wierda William G., Li, S, Nina Shah   +49 more
core   +2 more sources

A case series of necrotizing periodontal diseases in hospitalized patients: What hasn't been said yet?

Clinical Advances in Periodontics, EarlyView.
Abstract Background Necrotizing periodontal diseases (NPDs) are uncommon and severe inflammatory conditions characterized by tissue necrosis, painful ulceration, and rapid clinical progression, frequently associated with systemic immunosuppression. Limited data exist regarding their clinical presentation and management in hospital settings.
Osmaria Letthycia Carvalho Leal, Fernanda Bortolotto, Mariana Cristina Manoel, Gabriela Silveira de Araújo, Ana Carolina Fragoso Motta, Leandro Dorigan de Macedo, Lara Maria Alencar Ramos Innocentini, Joab Cabral Ramos, Isabel Schausltz Pereira Faustino   +8 more
wiley   +1 more source

Targeting CD20 in chronic lymphocytic leukemia

, 2015
Myrna R Nahas, Jon E ArnasonBeth Israel Deaconess Medical Center, Boston, MA, USAAbstract: Chronic lymphocytic leukemia (CLL), the most common leukemia in adults, is standardly managed with chemotherapy in combination with the anti-CD20 antibody ...
Nahas MR, Arnason JE
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From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs

Clinical Pharmacology &Therapeutics, EarlyView.
New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug disposition, pharmacological activity, and disease biology that are difficult
Karen Rowland Yeo, Piet H. van der Graaf
wiley   +1 more source

Idelalisib therapy of indolent B-cell malignancies: chronic lymphocytic leukemia and small lymphocytic or follicular lymphomas [PDF]

, 2016
Yazan F Madanat,1 Mitchell R Smith,2 Alexandru Almasan,3 Brian T Hill2 1Department of Internal Medicine, 2Department of Hematology and Medical Oncology, Taussig Cancer Institute, 3Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic,
Hill BT, Madanat YF, Smith MR, Almasan A
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Notch1 is induce by p53 as a possible anti-apoptotic mechanism in Chronic Lymphocytic Leukemia

, 2023
openNotch1 is induce by p53 as a possible anti-apoptotic mechanism in Chronic Lymphocytic ...
ZADRO, ALEX
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