Results 131 to 140 of about 92,728 (309)
International Journal of Cancer, EarlyView.Clinical trials of chimeric antigen receptor T‐cell (CAR‐T) therapies in glioblastoma have shown limited clinical benefits. Whether this may be explained by the basal quality of CAR‐T products, which are currently generated using patient, autologous T‐cells, has been little explored.
Sabra K. Salim +22 more
wiley +1 more source
Obinutuzumab in chronic lymphocytic leukemia: design, development and place in therapy
, 2017 Othman Al-Sawaf, Kirsten Fischer, Anja Engelke, Natali Pflug, Michael Hallek, Valentin Goede German CLL Study Group, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany Abstract: For decades, treatment of chronic ...
Hallek M +5 more
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International Journal of Cancer, EarlyView.ABSTRACT Pediatric cancer is a significant cause of morbidity and mortality in children. The etiologies of pediatric cancer are largely unknown, but environmental pesticide exposures are likely to contribute. Chronic low‐dose exposure to pesticide mixtures through drinking water is a growing concern in agricultural communities.
Grace N. VanDeSteeg +4 more
wiley +1 more source
, 2013 Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. Recently, recurrent activating mutations of NOTCH1 have been reported in up to 12% of CLL patients, underlining the relevance of NOTCH1 mutations (NOTCH1mut) as an independent ...
Grossmann, Vera +11 more
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International Journal of Cancer, EarlyView.Thyroid diseases are common among women of reproductive age and may be related to childhood cancer, but the evidence is inconsistent. This study of childhood cancer with maternal thyroid diseases and medication use in a population‐based case‐control study using Danish registries found positive associations between maternal goiter and overall cancer ...
Chuanjie Deng +5 more
wiley +1 more source
Obinutuzumab treatment in the elderly patient with chronic lymphocytic leukemia
, 2015 Karen Seiter, Aleksandra Mamorska-DygaDepartment of Medicine, Division of Hematology/Oncology, New York Medical College, Valhalla, NY, USA Abstract: Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries ...
Seiter K, Mamorska-Dyga A
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iLABMED, EarlyView.This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han +6 more
wiley +1 more source
Revista Brasileira de Hematologia e HemoterapiaBackground Distinction between mature B-cell neoplasms can be difficult due to overlapping of immunologic features and clinical manifestations. This study investigated whether quantifying mean fluorescence intensity of four monoclonal antibodies in a ...
Elissandra Machado Arlindo +3 more
doaj +1 more source
A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside
Interdisciplinary Medicine, EarlyView.This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione +2 more
wiley +1 more source