Results 11 to 20 of about 281,573 (395)

Targeting the Ataxia Telangiectasia Mutated-null Phenotype in Chronic Lymphocytic Leukemia with Pro-oxidants [PDF]

Haematologica, 2015
Inactivation of the Ataxia Telangiectasia Mutated gene in chronic lymphocytic leukemia results in resistance to p53-dependent apoptosis and inferior responses to treatment with DNA damaging agents. Hence, p53-independent strategies are required to target
Agathanggelou, A., Coles, Steven, Darley, R.L., Davies, N.J., Fossey, J.S., Hayes, J.D., Hole, P.S., McMahon, M., Moss, P., Oldreive, C.E., Oscier, D., Parry, H., Payne, D.T., Perry, T., Pratt, G., Skowronska, A., Stankovic, T., Stewart, G., Taylor, M., Wei, W., Weston, V.J.   +20 more
core   +6 more sources

The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax [PDF]

Haematologica, 2018
Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins. In the study herein, the pro-apoptotic effect of fluorizoline was assessed in 34 primary samples from patients with chronic lymphocytic leukemia ...
Albericio Palomera, Fernando, Banda, Esmeralda de la, Cosialls Castel, Ana Mª, Gil i Santano, Joan, González Barca, Eva, González Gironés, Diana M., Iglesias i Serret, Daniel, Lavilla Grífols, Rodolfo, Núñez-Vázquez, Sonia, Pomares, Helena, Pons i Irazazábal, Gabriel, Preciado Gallego, Sara, Saura-Esteller, José   +12 more
core   +3 more sources

Lenalidomide interferes with tumor-promoting properties of nurse-like cells in chronic lymphocytic leukemia [PDF]

Haematologica, 2014
Lenalidomide is an immunomodulatory agent clinically active in chronic lymphocytic leukemia patients. The specific mechanism of action is still undefined, but includes modulation of the microenvironment.
Audrito, V, BULGARELLI, Jenny, COLACI, ELISABETTA, Deaglio, S, FIORCARI, STEFANIA, LUPPI, Mario, MAFFEI, Rossana, MARASCA, Roberto, MARTINELLI, Silvia, NARNI, Franco, POTENZA, Leonardo, ZUCCHINI, Patrizia   +11 more
core   +4 more sources

Spectrum and trigger identification of hemophagocytic lymphohistiocytosis in adults: A single-center analysis of 555 cases

Frontiers in Immunology, 2022
Limited data are available about the underlying causes of hemophagocytic lymphohistiocytosis (HLH) in adults. We collected and analyzed the data of 555 cases of adult HLH.
Yi Miao, Yi Miao, Yi Miao, Jing Zhang, Jing Zhang, Jing Zhang, Qingqing Chen, Qingqing Chen, Qingqing Chen, Lingxiao Xing, Lingxiao Xing, Lingxiao Xing, Tonglu Qiu, Tonglu Qiu, Tonglu Qiu, Huayuan Zhu, Huayuan Zhu, Huayuan Zhu, Li Wang, Li Wang, Li Wang, Lei Fan, Lei Fan, Lei Fan, Wei Xu, Wei Xu, Wei Xu, Jianyong Li, Jianyong Li, Jianyong Li, Jianyong Li   +30 more
doaj   +1 more source

The pyroptosis-related gene signature predicts prognosis and indicates the immune microenvironment status of chronic lymphocytic leukemia

Frontiers in Immunology, 2022
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world with great heterogeneity. Pyroptosis has recently been recognized as an inflammatory form of programmed cell death (PCD) and shares a close relationship with apoptosis ...
Yeqin Sha, Yeqin Sha, Yeqin Sha, Rui Jiang, Rui Jiang, Rui Jiang, Yi Miao, Yi Miao, Yi Miao, Shuchao Qin, Shuchao Qin, Shuchao Qin, Wei Wu, Wei Wu, Wei Wu, Yi Xia, Yi Xia, Yi Xia, Li Wang, Li Wang, Li Wang, Lei Fan, Lei Fan, Lei Fan, Hui Jin, Hui Jin, Hui Jin, Wei Xu, Wei Xu, Wei Xu, Jianyong Li, Jianyong Li, Jianyong Li, Jianyong Li, Huayuan Zhu, Huayuan Zhu, Huayuan Zhu   +36 more
doaj   +1 more source

Targeting Bruton’s Tyrosine Kinase in CLL

Frontiers in Immunology, 2021
Targeting the B-cell receptor signaling pathway through BTK inhibition proved to be effective for the treatment of chronic lymphocytic leukemia (CLL) and other B-cell lymphomas.
Inhye E. Ahn, Jennifer R. Brown
doaj   +1 more source

AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression

Frontiers in Oncology, 2021
The enzyme activation-induced cytidine deaminase (AID) initiates somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes, critical actions for an effective adaptive immune response.
Pablo Oppezzo, Marcelo Navarrete, Nicholas Chiorazzi   +2 more
doaj   +1 more source

Monitoring and Managing BTK Inhibitor Treatment-Related Adverse Events in Clinical Practice

Frontiers in Oncology, 2021
Bruton tyrosine kinase (BTK) inhibitors represent an important therapeutic advancement for B cell malignancies. Ibrutinib, the first-in-class BTK inhibitor, is approved by the US FDA to treat patients with chronic lymphocytic leukemia (CLL)/small ...
Susan M. O’Brien, Jennifer R. Brown, John C. Byrd, Richard R. Furman, Paolo Ghia, Jeff P. Sharman, William G. Wierda   +6 more
doaj   +1 more source

The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives

Frontiers in Oncology, 2023
Hairy cell leukemia (HCL) is an incurable, rare lymphoproliferative hematological malignancy of mature B cAlthough first line therapy with purine analogues leads to positive results, almost half of HCL patients relapse after 5-10 years, and standard ...
Ernesto Gargiulo, Ernesto Gargiulo, Ernesto Gargiulo, Mirta Giordano, Carsten U. Niemann, Carsten U. Niemann, Etienne Moussay, Jérôme Paggetti, Pablo Elías Morande, Pablo Elías Morande   +9 more
doaj   +1 more source

COVID-19 vaccine efficacy in patients with chronic lymphocytic leukemia

Leukemia, 2021
While randomized controlled trials demonstrated 94–95% efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike messenger RNA (mRNA) vaccines [1, 2], efficacy in immunocompromised patients has not been established.
L. Roeker, D. Knorr, Meghan C. Thompson, Mariely Nivar, Sonia Lebowitz, N. Peters, I. Deonarine, Saddia Momotaj, Saumya Sharan, Vanessa Chanlatte, Bianca Hampton, Liana Butala, L. Amato, Angela Richford, Jessica Lunkenheimer, K. Battiato, Carissa Laudati, A. Mato   +17 more
semanticscholar   +1 more source