Results 11 to 20 of about 248,205 (145)

Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway. [PDF]

, 2015
The CXCR4 receptor (Chemokine C-X-C motif receptor 4) is highly expressed in different hematological malignancies including chronic lymphocytic leukemia (CLL).
Ale-Ali, Amine, Amaya-Chanaga, Carlos I, Cardarelli, Pina M, Castro, Januario E, Choi, Michael Y, Cohen, Lewis J, Jones, Harrison, Kashyap, Manoj K, Kipps, Thomas J, Kuhne, Michelle R, Kumar, Deepak, Melo-Cardenas, Johanna, Rassenti, Laura Z, Sabbatini, Peter, Shelat, Suresh G   +14 more
core   +11 more sources

Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with chronic lymphocytic leukemia

Blood, 2021
Patients with chronic lymphocytic leukemia (CLL) have an increased risk for severe COVID-19 disease and mortality. The goal of this study (NCT04746092) was to determine the efficacy of COVID-19 vaccine in patients with CLL.
Y. Herishanu, I. Avivi, A. Aharon, G. Shefer, S. Levi, Yotam Bronstein, M. Morales, T. Ziv, Yamit Shorer Arbel, L. Scarfò, E. Joffe, C. Perry, P. Ghia   +12 more
semanticscholar   +1 more source

First-Line Venetoclax Combinations in Chronic Lymphocytic Leukemia.

New England Journal of Medicine, 2023
BACKGROUND Randomized trials of venetoclax plus anti-CD20 antibodies as first-line treatment in fit patients (i.e., those with a low burden of coexisting conditions) with advanced chronic lymphocytic leukemia (CLL) have been lacking. METHODS In a phase
B. Eichhorst, C. Niemann, A. Kater, M. Fürstenau, Julia von Tresckow, Can Zhang, S. Robrecht, Michael Gregor, G. Juliusson, P. Thornton, P. Staber, T. Tadmor, V. Lindström, C. da Cunha-Bang, C. Schneider, C. B. Poulsen, T. Illmer, B. Schöttker, T. Nösslinger, A. Janssens, I. Christiansen, M. Baumann, H. Frederiksen, M. van der Klift, U. Jäger, M. Leys, M. Hoogendoorn, K. Lotfi, H. Hebart, T. Gaska, H. Koene, L. Enggaard, Jereon Goede, J. Regelink, A. Widmer, F. Simon, Nisha De Silva, A. Fink, J. Bahlo, K. Fischer, C. Wendtner, K. Kreuzer, M. Ritgen, M. Brüggemann, E. Tausch, M. Levin, M. V. van Oers, C. Geisler, S. Stilgenbauer, M. Hallek   +49 more
semanticscholar   +1 more source

Zanubrutinib or Ibrutinib in Relapsed or Refractory Chronic Lymphocytic Leukemia.

New England Journal of Medicine, 2022
BACKGROUND In a multinational, phase 3, head-to-head trial, ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, was compared with zanubrutinib, a BTK inhibitor with greater specificity, as treatment for relapsed or refractory chronic lymphocytic ...
Jennifer R. Brown, B. Eichhorst, P. Hillmen, W. Jurczak, M. Kaźmierczak, N. Lamanna, S. O'brien, C. Tam, L. Qiu, K. Zhou, M. Šimkovič, J. Mayer, A. Gillespie-Twardy, A. Ferrajoli, P. Ganly, R. Weinkove, S. Grosicki, A. Mital, T. Robak, A. Osterborg, H. Yimer, T. Salmi, M. Wang, L. Fu, Jessica Li, Kenneth Wu, A. Cohen, M. Shadman   +27 more
semanticscholar   +1 more source

Chronic lymphocytic leukemia: 2022 update on diagnostic and therapeutic procedures

American journal of hematology/oncology, 2021
Chronic lymphocytic leukemia (CLL) is one of the most frequent types of leukemia. It typically occurs in elderly patients and has a highly variable clinical course.
M. Hallek, O. Al-Sawaf
semanticscholar   +1 more source

COVID-19 vaccine efficacy in patients with chronic lymphocytic leukemia

Leukemia, 2021
While randomized controlled trials demonstrated 94–95% efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike messenger RNA (mRNA) vaccines [1, 2], efficacy in immunocompromised patients has not been established.
L. Roeker, D. Knorr, Meghan C. Thompson, Mariely Nivar, Sonia Lebowitz, N. Peters, I. Deonarine, Saddia Momotaj, Saumya Sharan, Vanessa Chanlatte, Bianca Hampton, Liana Butala, L. Amato, Angela Richford, Jessica Lunkenheimer, K. Battiato, Carissa Laudati, A. Mato   +17 more
semanticscholar   +1 more source

Detection of early seeding of Richter transformation in chronic lymphocytic leukemia

Nature Network Boston, 2022
Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia (CLL) into a very aggressive large B cell lymphoma conferring a dismal prognosis. The mechanisms driving RT remain largely unknown. We characterized the whole genome,
F. Nadeu, R. Royo, Ramon Massoni-Badosa, Heribert Playa-Albinyana, Beatriz García-Torre, M. Duran-Ferrer, K. Dawson, M. Kulis, A. Díaz-Navarro, N. Villamor, J. L. Melero, V. Chapaprieta, Ana Dueso-Barroso, Julio Delgado, R. Moia, Sara Ruiz-Gil, Domenica Marchese, A. Giró, Núria Verdaguer-Dot, M. Romo, G. Clot, M. Rozman, G. Frigola, A. Rivas-Delgado, T. Baumann, M. Alcoceba, Marcos González, F. Climent, P. Abrisqueta, J. Castellví, F. Bosch, M. Aymerich, A. Enjuanes, S. Ruiz-Gaspà, A. López-Guillermo, P. Jares, S. Beá, S. Capella-Gutiérrez, J. Gelpi, N. López-Bigas, D. Torrents, P. Campbell, I. Gut, D. Rossi, G. Gaidano, X. Puente, P. García-Rovés, D. Colomer, H. Heyn, F. Maura, J. Martín-Subero, E. Campo   +51 more
semanticscholar   +1 more source

Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKC subversion induces up-regulation of PKC II expression in B lymphocytes [PDF]

, 2015
Overwhelming evidence identifies the microenvironment as a critical factor in the development and progression of chronic lymphocytic leukemia, underlining the importance of developing suitable translational models to study the pathogenesis of the disease.
Cosimo, Emilio, Dunn, Karen, Gribben, John G., Holroyd, Ailsa, Mccaig, Alison M., McClanahan, Fabienne, Michie, Alison, Nakagawa, Rinako, Ramsay, Alan G., Tarafdar, Anuradha, Vukovic, Milica   +10 more
core   +3 more sources

Genomic aberrations and survival in chronic lymphocytic leukemia.

New England Journal of Medicine, 2000
BACKGROUND Fluorescence in situ hybridization has improved the detection of genomic aberrations in chronic lymphocytic leukemia. We used this method to identify chromosomal abnormalities in patients with chronic lymphocytic leukemia and assessed their ...
H. Döhner, S. Stilgenbauer, A. Benner, E. Leupolt, A. Kröber, L. Bullinger, K. Döhner, Martin Bentz, P. Lichter   +8 more
semanticscholar   +1 more source

Chronic lymphocytic leukemia and the central nervous system: a clinical and pathological study. [PDF]

, 1996
Chronic lymphocytic leukemia is the most common human leukemia but infrequently causes neurologic symptoms. We have reviewed all previously reported cases of chronic lymphocytic leukemia in the CNS along with three new cases; one patient was diagnosed ...
Cramer, SC, Efird, JT, Glaspy, JA, Louis, DN   +3 more
core   +2 more sources