Results 21 to 30 of about 82,620 (274)
Chronic lymphocytic leukemia cells are active participants in microenvironmental cross-talk
Haematologica, 2017 The importance of the tumor microenvironment in chronic lymphocytic leukemia is widely accepted. Nevertheless, the understanding of the complex interplay between the various types of bystander cells and chronic lymphocytic leukemia cells is incomplete ...
Martijn HA van Attekum +2 more
doaj +1 more source
PLoS ONE, 2021 Flow cytometry immunophenotyping has an essential role in distinguishing chronic lymphocytic leukemia from other B-chronic lymphoproliferative disorders. Recently, CD200 is considered as a relatively consistent marker in chronic lymphocytic leukemia.
Sana Dlawar Jalal
doaj +1 more source
Copy-number-variation and copy-number-alteration region detection by cumulative plots [PDF]
BMC Bioinformatics, 10(suppl 1):S67 (2009), 2009 Background: Regions with copy number variations (in germline cells) or copy number alteration (in somatic cells) are of great interest for human disease gene mapping and cancer studies. They represent a new type of mutation and are larger-scaled than the single nucleotide polymorphisms.
arxiv +1 more source
Bruton tyrosine kinase inhibitors in the management of Waldenström macroglobulinemia
American Journal of Hematology, Volume 98, Issue 2, Page 338-347, February 2023., 2023 Abstract Bruton tyrosine kinase (BTK) inhibitors have taken a central role in the management of patients with Waldenström macroglobulinemia and are the only agents approved by the Food and Drug Administration (FDA) to treat these patients. Although associated with high rates of durable responses, unmet needs with BTK inhibitor therapy include ...
Jorge J. Castillo +4 more
wiley +1 more source
Haematologica, 2009 Background Previous studies have shown increased familial risk for chronic lymphocytic leukemia. In the most comprehensive study to date, we evaluated risk of chronic lymphocytic leukemia and lymphoproliferative disorders among first-degree relatives of ...
Lynn R. Goldin +4 more
doaj +1 more source
Machine Learning Approaches to Automated Flow Cytometry Diagnosis of Chronic Lymphocytic Leukemia [PDF]
arXiv, 2021 Flow cytometry is a technique that measures multiple fluorescence and light scatter-associated parameters from individual cells as they flow a single file through an excitation light source. These cells are labeled with antibodies to detect various antigens and the fluorescence signals reflect antigen expression.
arxiv
Haematologica, 2018 Chronic lymphocytic leukemia is a disease with up-regulated expression of the transmembrane tyrosine-protein kinase ROR1, a member of the Wnt/planar cell polarity pathway. In this study, we identified COBLL1 as a novel interaction partner of ROR1. COBLL1
Hana Plešingerová +12 more
doaj +1 more source
Cyclosporine A therapy of chronic lymphoblastic leukemia‐related pancytopenia: A case report
Clinical Case Reports, 2022 To explore the clinical characteristics, diagnosis, and treatment of chronic lymphocytic leukemia with secondary pancytopenia. Here, a case of pancytopenia secondary to chronic lymphocytic leukemia is reported.
Mengying Wang +9 more
doaj +1 more source
A New Deep Learning and XAI-Based Algorithm for Features Selection in Genomics [PDF]
arXiv, 2023 In the field of functional genomics, the analysis of gene expression profiles through Machine and Deep Learning is increasingly providing meaningful insight into a number of diseases. The paper proposes a novel algorithm to perform Feature Selection on genomic-scale data, which exploits the reconstruction capabilities of autoencoders and an ad-hoc ...
arxiv
SAGE Open Medical Case Reports, 2016 Chronic lymphocytic leukemia, the most common adult leukemia worldwide, is considered an indolent but incurable non-Hodgkin lymphoma. Leukemia cutis is an uncommon manifestation of chronic lymphocytic leukemia.
Ali Raufi +4 more
doaj +1 more source