Chronic Migraine Pathophysiology and Treatment: A Review of Current Perspectives
Frontiers in Pain Research, 2021 Chronic migraine is a disabling neurological disorder that imposes a considerable burden on individual and socioeconomic outcomes. Chronic migraine is defined as headaches occurring on at least 15 days per month with at least eight of these fulfilling ...
Tiffani J. Mungoven +2 more
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PLoS ONE, 2013 BACKGROUND: People who have a disease often experience stigma, a socially and culturally embedded process through which individuals experience stereotyping, devaluation, and discrimination.
William B Young +3 more
doaj +5 more sources
IL-17 crosses the blood–brain barrier to trigger neuroinflammation: a novel mechanism in nitroglycerin-induced chronic migraine [PDF]
The Journal of Headache and Pain, 2022 Background Chronic migraine places a disabling burden on patients, which is extensively modeled by the nitroglycerin (NTG)-treated animal model. Although the NF-κB pathway is involved in an increase in CGRP levels and activation of the trigeminal system ...
Hao Chen +7 more
openalex +2 more sources
Monocentric Prospective Study into the Sustained Effect of Incobotulinumtoxin A (XEOMIN®) Botulinum Toxin in Chronic Refractory Migraine [PDF]
Toxins, 2018 Refractory chronic migraine is a disabling disorder impacting quality of life. BOTOX® (Onabotulinumtoxin A) is approved as a prophylactic treatment of chronic migraine in patients unresponsive to at least three prior preventive treatments.
Ioana Ion +7 more
doaj +2 more sources
Fremanezumab for the Preventive Treatment of Chronic Migraine. [PDF]
New England Journal of Medicine, 2017 BACKGROUND: Fremanezumab, a humanized monoclonal antibody targeting calcitonin gene-related peptide (CGRP), is being investigated as a preventive treatment for migraine.
Aycardi, Ernesto +9 more
core +3 more sources
Treatment of resistant chronic migraine with anti-CGRP monoclonal antibodies: a systematic review
European Journal of Medical Research, 2022 Background Resistant chronic migraine is a highly disabling condition which is very difficult to treat. The majority of the treatments for migraine prophylaxis are nonspecific and present weak safety profiles, leading to low adherence and discontinuation.
Hugo Sevivas, Paula Fresco
doaj +2 more sources
Offset analgesia as a marker of dysfunctional pain modulation in episodic and chronic migraine [PDF]
The Journal of Headache and PainBackground The offset analgesia phenomenon refers to the disproportionately large decrease in the perceived pain following a slight decrease in intensity of a noxious heat stimulus.
Giuseppe Cosentino +8 more
doaj +2 more sources
Compromised PGF2α signaling in the paraventricular hypothalamic nucleus contributes to the central sensitization of the nitroglycerin-induced chronic migraine in male mice [PDF]
The Journal of Headache and PainImpaired descending inhibitory controls are now understood to exacerbate central sensitization of chronic migraine, yet the underlying neural and molecular mechanisms remain largely elusive.
Xianrong Hu +10 more
doaj +2 more sources
Long-term tolerability and effectiveness of eptinezumab in Japanese adults with chronic migraine: results of the 60-week open-label SUNSET trial. [PDF]
J Headache PainTakeshima T +8 more
europepmc +2 more sources
CNS Drugs, 2022 Criteria, including clinical features and effective outcomes, for access and persistence of novel but costly treatments may vary between countries, thus affecting the health of patients.
L. Iannone +5 more
semanticscholar +1 more source