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Chronic Migraine Pathophysiology and Treatment: A Review of Current Perspectives
Frontiers in Pain Research, 2021 Chronic migraine is a disabling neurological disorder that imposes a considerable burden on individual and socioeconomic outcomes. Chronic migraine is defined as headaches occurring on at least 15 days per month with at least eight of these fulfilling ...
Tiffani J. Mungoven +2 more
doaj +2 more sources
Management of chronic migraine
BMJ, 2022 Chronic migraine is a neurologic disorder associated with considerable disability, lost productivity, and a profound economic burden worldwide. The past five years have seen a dramatic expansion in new treatments for this often challenging condition ...
A. Hovaguimian, Julie Roth
semanticscholar +3 more sources
Treatment of resistant chronic migraine with anti-CGRP monoclonal antibodies: a systematic review
European Journal of Medical Research, 2022 Background Resistant chronic migraine is a highly disabling condition which is very difficult to treat. The majority of the treatments for migraine prophylaxis are nonspecific and present weak safety profiles, leading to low adherence and discontinuation.
Hugo Sevivas, Paula Fresco
doaj +2 more sources
The Chronic Migraine Brain: What Have We Learned From Neuroimaging?
Frontiers in Neurology, 2020 Chronic migraine is a highly disabling disease with a great impact on socioeconomic functioning and quality of life of migraine patients. Chronic migraine usually evolves from episodic migraine that gradually increases in attack frequency, supporting the
Massimo Filippi +4 more
doaj +2 more sources
Current and emerging evidence-based treatment options in chronic migraine: a narrative review
The Journal of Headache and Pain, 2019 Background Chronic migraine is a disabling condition that is currently underdiagnosed and undertreated. In this narrative review, we discuss the future of chronic migraine management in relation to recent progress in evidence-based pharmacological ...
Elio Clemente Agostoni +15 more
doaj +2 more sources
Offset analgesia as a marker of dysfunctional pain modulation in episodic and chronic migraine. [PDF]
J Headache PainBackground The offset analgesia phenomenon refers to the disproportionately large decrease in the perceived pain following a slight decrease in intensity of a noxious heat stimulus.
Cosentino G +8 more
europepmc +2 more sources
The Journal of Headache and Pain, 2022 Background Chronic migraine places a disabling burden on patients, which is extensively modeled by the nitroglycerin (NTG)-treated animal model. Although the NF-κB pathway is involved in an increase in CGRP levels and activation of the trigeminal system ...
Hao Chen +7 more
semanticscholar +1 more source
CNS Drugs, 2022 Criteria, including clinical features and effective outcomes, for access and persistence of novel but costly treatments may vary between countries, thus affecting the health of patients.
L. Iannone +5 more
semanticscholar +1 more source
The Journal of Headache and Pain, 2022 Background Clinical trials have shown that erenumab is effective and well-tolerated for the preventive treatment of chronic migraine. To extend the results from clinical trials, we assessed the real-world efficacy and safety of erenumab in patients with ...
C. K. Cullum +10 more
semanticscholar +1 more source
The Journal of Headache and Pain, 2022 Background and aims Chronic migraine is a common neurovascular brain disorder with substantial economic costs. We performed a systematic review to identify economic evaluations of pharmacological treatments for adults with chronic migraine.
S. Khanal +6 more
semanticscholar +1 more source