Results 101 to 110 of about 2,712,287 (341)

Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition

Chemistry &Biodiversity, EarlyView.
ABSTRACT Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Najlaa Hamed Almohmadi, Hayder M. Al‐Kuraishy, Ali I. Al‐Gareeb, Ali K. Albuhadily, Morkoss M. Fakhry, Athanasios Alexiou, Marios Papadakis, Gaber El‐Saber Batiha   +7 more
wiley   +1 more source

Galcanezumab in chronic migraine

Neurology, 2018
Objective To evaluate the efficacy and safety of galcanezumab, a humanized monoclonal antibody that selectively binds to calcitonin gene-related peptide, in the preventive treatment of chronic migraine.
H. Detke, P. Goadsby, Shufang Wang, D. Friedman, Katherine J Selzler, S. Aurora   +5 more
semanticscholar   +1 more source

NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES

ChemMedChem, Accepted Article.
Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean-François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Loneliness and Migraine Self-Management: A Cross-Sectional Assessment

Journal of Primary Care & Community Health, 2020
Background: Chronic illness is often comorbid with the psychological state of loneliness. Models of care for patients who experience chronic migraines may often lack an understanding of psychosocial influences of the illness.
Jacob Z. Lui, Nathan P. Young, Jon O. Ebbert, Jordan K. Rosedahl, Lindsey M. Philpot   +4 more
doaj   +1 more source

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano, Milko Massimiliano Radicioni, Gerhard Garhöfer, Martina Cartwright, Markus Müller, Iris Kopeloff, Luigi Moro, Nicholas Squittieri, Alessandro Mazzetti   +8 more
wiley   +1 more source

Management of Chronic Migraine in Children and Adolescents: Where are We in 2022?

Pediatric Health, Medicine and Therapeutics, 2022
Robert C Gibler,1 Kaelynn E Knestrick,1 Brooke L Reidy,1,2 Daniel N Lax,3,4 Scott W Powers1,2,4 1Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA; 2Department of Pediatrics ...
Gibler RC, Knestrick KE, Reidy BL, Lax DN, Powers SW   +4 more
doaj  

Continuing medical education in epileptology: The Level 1‐2‐3 experience of the ILAE academy

Epileptic Disorders, EarlyView.
Abstract The International League Against Epilepsy (ILAE) Academy is the world's eminent e‐learning campus for epileptology. Its modular teaching content was developed to cover all competencies and learning objectives specified in the ILAE's curriculum for epileptology.
Ingmar Blümcke, Eva Biesel, Samuel Wiebe, Sandor Beniczky, Jo M. Wilmshurst, Man Mohan Mehndiratta, Ali A. Asadi‐Pooya, Christian Brandt, Alexis Arzimanoglou, Gagandeep Singh, on behalf of the ILAE Academy content development faculty, Raidah Al Baradie, Carmen Barba, Jocelyn F. Bautista, Sallie Baxendale, Elena Belousova, Isabella Brambilla, Jorge G. Burneo, Leonor Cabral‐Lim, Jaime Carrizosa, Jaume Campistol, Hannah Cock, Marion Comajuan, Helen Cross, Emilija Cvetkovska, Valentina De Giorgis, Luca De Palma, Kirsten A. Donald, Georg Dorfmüller, Guadalupe Fernandez Baca Vaca, Jessica Fesler, Irene García Morales, Christina Giavasi, Maria Gogou, Patricia Gómez Iglesias, Samson Gwer, Till Hartlieb, Martin Holtkamp, Floor E. Jansen, Bosanka Jocic‐Jakubi, Philippe Kahane, Ioannis Karakis, Takafumi Kubota, Joshua Laing, Tatjana Liakina, Aileen McGonigal, Rosa Michaelis, Ioana Mindruta, Andrew Neal, Maureen Njoroge, Irina Oane, Terence O’Brien, Finbar O’Callaghan, Manuela Ochoa Urrea, Nicholas Odero, Sebastián Ortiz, Karine Ostrowsky‐Coste, Maria T. Papadopoulou, Tiziana Pisano, Anna Rada, Stefan Rampp, Markus Reuber, Sylvain Rheims, Andrea O. Rossetti, Guido Rubboli, Victoria San Antonio‐Arce, Jan‐Christoph Schoene‐Bake, Artem Sharkov, Hugh D. Simpson, Mary Lou Smith, Ana Suller Marti, Rainer Surges, Roland Thijs, Joseph Toulouse, Bart van den Munckhof, Bernd J. Vorderwülbecke, Alistair Wardrope, Peter Wolf, Elza Márcia Yacubian   +78 more
wiley   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Dopamine D2 Receptor Activation Blocks GluA2/ROS Positive Feedback Loop to Alienate Chronic-Migraine-Associated Pain Sensitization

Antioxidants
Chronic migraine is a disabling disorder without effective therapeutic medicine. AMPA receptors have been proven to be essential to pathological pain and headaches, but the related regulatory mechanisms in chronic migraine have not yet been explored.
Wei Zhang, Xiaoyan Zhang, Ming Lei, Dunke Zhang, Guangcheng Qin, Jiying Zhou, Lichun Ji, Lixue Chen   +7 more
doaj   +1 more source

Exploring the Molecular Pathways Underlying the Anti‐Diabetic Effects of Millets

Food Safety and Health, EarlyView.
Millet consumption may modulate gluconeogenesis and glycolysis, enhance glucose transporter activity, increase leptin levels, inhibit the NF‐κB pathway, and mitigate oxidative and nitrosative stress. ABSTRACT Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemic conditions resulting from inadequate insulin production or ...
Akash Kumar, Nidhi N. Shah, Mehul R. Chorawala, Rekha Kaushik, Bhupendra Prajapati, Rahul Mehra   +5 more
wiley   +1 more source