Results 111 to 120 of about 98,841 (309)

Development of an Efficient and Scalable Process for Preparing Timolol N‐Nitrosamine Impurities B, C, E, H, I, J, and Their ADMET Evaluation

Journal of Heterocyclic Chemistry, EarlyView.
N‐nitrosamine impurities (B, C, E, H, I, J) of timolol maleate are easily synthesized from diethyl malonate and 3,4‐dichloro‐1,2,5‐thiadiazole. Good yields and precise impurity profiling are made possible by the effective technique, which also ensures pharmaceutical safety and strengthens regulatory compliance.
Kottolla Sai Prasad, Chithaluri Sudhakar, Vijaya Krishna Ravi, Bijaya Kethan Sahoo   +3 more
wiley   +1 more source

Correlation between migraine subtipes and depression Correlação entre subtipos de migrânea e depressão

Arquivos de Neuro-Psiquiatria, 2008
This study has evaluated depression in patients with episodic migraine (n=98), chronic migraine without medication overuse (n=23), and chronic migraine with medication overuse (n=57).
Renan Barros Domingues, Esther Angélica Coelho Costa, Ariovaldo da Silva Jr, Simone Aires Domingues, Juliana Cardoso Leal, Rodrigo Santiago Gomez, Antônio Lúcio Teixeira Jr   +6 more
doaj   +1 more source

Loneliness and Migraine Self-Management: A Cross-Sectional Assessment

Journal of Primary Care & Community Health, 2020
Background: Chronic illness is often comorbid with the psychological state of loneliness. Models of care for patients who experience chronic migraines may often lack an understanding of psychosocial influences of the illness.
Jacob Z. Lui, Nathan P. Young, Jon O. Ebbert, Jordan K. Rosedahl, Lindsey M. Philpot   +4 more
doaj   +1 more source

Motor skills in children with primary headache: A pilot case-control study [PDF]

, 2018
Background: Headache is the most common painful manifestation in the developmental age, often accompanied by severe disability such as scholastic absenteeism, low quality of academic performance and compromised emotional functioning. The aim of the study
Cerroni F., Chisari M. G., D'Oro L., Di Folco A., Gallai B., Geraci D., Lavano F., Lavano S. M., Magliulo R. M., Marotta R., Marsala G., Murabito P., Parisi L., Picciocchi E., Polito A. N., Romano P., Russo D., Salerno M., Salerno M., Sorrentino M., Testa D., Tripi G.   +21 more
core   +1 more source

Antibiotics in the first week of life are not associated with functional gastrointestinal disorders at 9–12 years of age

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Dysbiosis due to early‐life antibiotics may contribute to the development of functional gastrointestinal disorders (FGIDs). This follow‐up study of a birth cohort primarily investigates the association between antibiotic treatment in the first week of life and the presence of FGIDs at 9–12 years.
Nora C. Carpay, Kim Kamphorst, Ruurd M. van Elburg, Arine M. Vlieger   +3 more
wiley   +1 more source

Children and adolescents with disorders of gut–brain interaction with comorbid hypermobility and orthostatic intolerance have worse outcomes

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Disorders of gut–brain interaction (DGBI) affect about 40% of children and are often comorbid with hypermobility spectrum disorders (HSDs) and orthostatic intolerance (OI). However, how these comorbidities impact outcomes in pediatric DGBI is not well understood.
Neha Santucci, Austin VonAxelson, Jesse Li, Kahleb Graham, Jennifer Hardy, Megan Miller, Rashmi Sahay   +6 more
wiley   +1 more source

Dopamine D2 Receptor Activation Blocks GluA2/ROS Positive Feedback Loop to Alienate Chronic-Migraine-Associated Pain Sensitization

Antioxidants
Chronic migraine is a disabling disorder without effective therapeutic medicine. AMPA receptors have been proven to be essential to pathological pain and headaches, but the related regulatory mechanisms in chronic migraine have not yet been explored.
Wei Zhang, Xiaoyan Zhang, Ming Lei, Dunke Zhang, Guangcheng Qin, Jiying Zhou, Lichun Ji, Lixue Chen   +7 more
doaj   +1 more source

Elimination of pain improves specificity of clinical diagnostic criteria for adult chronic rhinosinusitis [PDF]

, 2017
Objective Determine whether the elimination of pain improves accuracy of clinical diagnostic criteria for adult chronic rhinosinusitis. Study Design Retrospective cohort study.
DiNardo, Laurence J., Hirsch, Scott D., Reiter, Evan R., Schuman, Theodore A., Wan, Wen   +4 more
core   +2 more sources

Migraine - Chronic vs. Chronic

Epidemiology: Open Access, 2015
I have written this article because I’m very worried about the lack of understanding, interest and political actions concerning migraine despite the pain and social problems it causes for the individual. Despite it’s great impact on the economy all over the world.
openaire   +1 more source

Balance Disorders in Young and Middle‐Aged Adults: NHANES, 2001–2004 and 2021–2023

The Laryngoscope, EarlyView.
This study presents nationally‐representative estimates from two health exam surveys, NHANES 2001–2004 and 2021–2023. In the two decades between test periods, scores on the modified Romberg screening test for balance function demonstrated significantly better age‐specific performance in 2021–2023.
Howard J. Hoffman, Diana E. Fisher, Anne E. Hogan, Helen S. Cohen, Gregory A. Flamme, Christa L. Themann, Chuan‐Ming Li, Bryan K. Ward, Charles C. Della Santina   +8 more
wiley   +1 more source