Results 131 to 140 of about 98,841 (309)

Botulinum toxin use in patients with neurological disorders: A U.S.‐based claims database analysis

PM&R, EarlyView.
Abstract Background and Objective Real‐world evidence describing long‐term persistency with botulinum toxin (BoNT) therapy is limited. We assessed treatment patterns and persistency with BoNT in clinical practice over 2 years. Design Retrospective, longitudinal, claims database analysis. Setting Medical claims data from the Merative MarketScan database
David M. Simpson, Jonathan Bouchard, Simon Page, Seth Goldfarb, Atul T. Patel   +4 more
wiley   +1 more source

Improvements in interoceptive sensibility, pain and functional clinical outcome measures after participation in an interdisciplinary pain management program

PM&R, EarlyView.
Abstract Background Altered interoception, the sense of signals from inside the body, is linked to chronic pain. No studies to date have examined whether interoceptive sensibility, one's self‐reported beliefs about the body and tendencies to be internally focused, changes following participation in an interdisciplinary pain management program (IPMP ...
Stephanie Voss, Shannon La Penna, Alison Yum, Neha P. Gothe, Christine M. Gagnon   +4 more
wiley   +1 more source

Efficacy and safety of DFN-11 (sumatriptan injection, 3 mg) in adults with episodic migraine: a multicenter, randomized, double-blind, placebo-controlled study. [PDF]

, 2018
BackgroundIn a previous randomized, double-blind, proof-of-concept study in rapidly escalating migraine, a 3 mg dose of subcutaneous sumatriptan (DFN-11) was associated with fewer and shorter triptan sensations than a 6 mg dose.
Brand-Schieber, Elimor, Landy, Stephen, Munjal, Sagar, Rapoport, Alan M   +3 more
core   +1 more source

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source

Cellular and molecular characterisation of the peripheral immune environment in migraine

PAIN Reports
. Introduction:. Peripheral immune dysfunction may be critically involved in the pathophysiology of migraine. Some evidence supports a role for peripheral T cells, monocytes, and humoral factors including kynurenine metabolites and cytokines, however a ...
Jayden A. O'Brien, Benjamin Heng, Seong Beom Ahn, Ananda Staats-Pires, Ashleigh Wake, Rebecca Wong, Aimie L. Peek, Noemi Meylakh, Karl Ng, Richard Stark, Vaughan G. Macefield, Helen M. McGuire, Luke A. Henderson, Paul J. Austin   +13 more
doaj   +1 more source

Analysis of serum biomarkers associated with pain in Spanish greyhounds undergoing ovariohysterectomy

Veterinary Record, EarlyView.
Background This study measured serum biomarkers at baseline and during an ovariohysterectomy in healthy female Spanish greyhounds, aiming to enhance the objectivity of current methods for assessing acute postoperative pain in dogs. Methods Blood samples from 20 Spanish greyhounds were collected before drug administration (T0‐baseline).
Rocio Navarrete‐Calvo, Jose Andrés Fernández‐Sarmiento, Juan Morgaz, Alba Galán‐Rodríguez, Rafael J. Gómez‐Villamandos, Pablo Parra, María del Mar Granados, Setefilla Quirós‐Carmona, Irene M. Rodríguez‐Gómez   +8 more
wiley   +1 more source

Reduced brain entropy in migraine with partial restoration during attacks: A resting-state fMRI study

NeuroImage
Migraine is a prevalent and disabling neurological disorder, characterized by impaired regulation of migraine burden, sensory processing, and cognitive-emotional states.
Majid Saberi, Dajung J Kim, Xiao-Su Hu, Alexandre F DaSilva   +3 more
doaj   +1 more source

POLG‐Related Parkinsonism with Good Response to Deep Brain Stimulation

Movement Disorders Clinical Practice, EarlyView.
Evdokia Efthymiou, Fabian Büchele, Sujitha Mahendran, Lennart Stieglitz, Bettina Balint   +4 more
wiley   +1 more source

Osmophobia in Patients With Migraine: A Systematic Review and Meta‐Analysis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To determine the prevalence of osmophobia and to better characterize experiences reported by patients with migraine. Data Sources CINAHL, Cochrane Library, PubMed, and SCOPUS. Methods The literature was searched for articles reporting prevalence of osmophobia in patients with migraine. Primary outcome measures included proportions (%)
Erin E. Briggs, Anuja H. Shah, Shaun A. Nguyen, Chandler J. Curtis, Alexander N. Duffy, Zachary M. Soler, Rodney J. Schlosser   +6 more
wiley   +1 more source

Cognition, mental health, and quality of life in patients with chronic and episodic migraine during the interictal period

BMC Neurology
Introduction Migraine is a highly prevalent and disabling condition, not only due to its painful symptoms but also because of its significant impact on mental health and cognitive functioning, leading to a considerable deterioration in quality of life ...
Diana Carolina López-Medina, Alejandra Arboleda-Ramírez, Sara Ríos-Díaz, Renato Zambrano-Cruz, Andrés Arboleda-Jaramillo, Cristian Betancur-Henao, Marcela Henao-Pérez   +6 more
doaj   +1 more source