Results 151 to 160 of about 98,841 (309)

Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro, Pietro Pola, Michela Argentieri, Alessia Frezza, Matilde Marini, Francesco De Logu, Valentina Albanese, Marie Soukupova, Davide Malfacini, Nurulain T. Zaveri, Romina Nassini, Dane D. Jensen, Pierangelo Geppetti, Girolamo Calò, Chiara Ruzza   +14 more
wiley   +1 more source

Chronic migraine [PDF]

Neurologie pro praxi, 2019
openaire   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Headache disorders as risk factors for sleep disturbances in school aged children. [PDF]

, 2005
Several epidemiological studies have shown the presence of comorbidity between various types of sleep disorders and different headache subtypes. Migraine without aura is a sensitive risk factor for disorders of initiating and maintaining sleep (odds ...
CAROTENUTO, M, GALLI, FEDERICA, GUIDETTI, Vincenzo, PASCOTTO, A., RUJU, F, TAGLIENTE F., R   +5 more
core  

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Functional evaluation of the auditory brainstem in migraine patients using ABR and MLD tests

The Egyptian Journal of Otolaryngology
Background Migraine is a prevalent neurological disorder commonly associated with sensory disturbances, including phonophobia. These symptoms suggest possible involvement of central auditory pathways, particularly at the brainstem level, yet objective ...
Mohammad S. Ali, Hayam Abdel-Tawab, Ibrahim H. Abd-Elhmid, Soliman S. Ghanem, Hossam A. Hussein, Eman A. Elhamrawy, Tamer El-Esawy Abdel-Moaaty, Ahmed I. Abbas   +7 more
doaj   +1 more source

Early Detection of Lower Adherence to Long‐Term e‐Diary Recording: A Checkpoint to Target Early Educational Intervention in Seasonal Allergic Rhinitis?

Clinical &Experimental Allergy, EarlyView.
Adherence to e‐Diary reporting was investigated in a blended care setting among pollen allergic patients with heterogeneous cultural backgrounds. A stable ‘higher’ and a more variable ‘lower’ adherence cluster were identified. Early identification of lower adherence is possible and might inform early interventions to improve patient adherence. ABSTRACT
S. Dramburg, C. J. Hernandez Toro, U. Grittner, S. Tripodi, S. Arasi, A. Acar Şahin, X. Aggelidis, A. Barbalace, A. Bourgoin, B. Bregu, M. A. Brighetti, E. Caeiro, S. Caglayan Sozmen, L. Caminiti, D. Charpin, M. Couto, L. Delgado, A. Di Rienzo Businco, C. Dimier, M. V. Dimou, J. A. Fonseca, O. Goksel, D. Hernandez, T. M. Hoffmann, D. T. Jang, F. Kalpaklioglu, B. Lame, R. Llusar, M. Makris, A. Mazon, E. Mesonjesi, A. Nieto, A. Öztürk, L. Pahus, G. Pajno, I. Panasiti, N. G. Papadopoulos, E. Pellegrini, S. Pelosi, A. M. Pereira, M. Pereira, N. M. Pinar, E. Potapova, A. Priftanji, F. Psarros, C. Sackesen, I. Sfika, J. Suarez, M. Thibaudon, A. Travaglini, U. Uguz, V. Verdier, V. Villella, P. Xepapadaki, D. Yazici, P. M. Matricardi   +55 more
wiley   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Long‐term neurological and psychiatric outcomes after paediatric arterial ischaemic stroke and cerebral sinovenous thrombosis

Developmental Medicine &Child Neurology, EarlyView.
Arterial ischemic stroke (AIS) or cerebral sinovenous thrombosis (CSVT) is a rare but serious event in children and adolescents. A descriptive long‐term (median 16 years) follow‐up study of patients revealed an increased risk of neurological and psychiatric diagnoses after AIS or CSVT, highlighting significant morbidity compared with the general ...
Jeanette Soenderlyng Springer, Søren Paaske Johnsen, Charlotte Olesen, Jan Brink Valentin, Ruta Tuckuviene   +4 more
wiley   +1 more source