Results 151 to 160 of about 55,496 (259)

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Migrainous Thoracalgia in a Patient with Chronic Migraine and Coronary Vasospasm: A Case Report. [PDF]

Int Med Case Rep J
Zeldich D, Wang VS, David C, Lauritsen C, Ceriani C.   +4 more
europepmc   +1 more source

GLP‐1 receptor activation attenuates chronic migraine‐like behaviour: Sex‐specific modulation of opioid‐ and endocannabinoid‐related pathways

British Journal of Pharmacology, EarlyView.
Background and Purpose Chronic migraine (CM) is a highly disabling condition that remains suboptimally treated. Metabolic disturbances may trigger migraine chronification, whereas impaired endogenous pain inhibition contributes to CM development. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), used for type 2 diabetes and obesity, show efficacy ...
Katarina Sićović, Katarina Nastić, Miroslav Dinić, Emilija Brdarić, Uroš Pecikoza, Maja Tomić, Ana Micov   +6 more
wiley   +1 more source

Long-term neuromuscular alterations during botulinum toxin treatment for chronic migraine. [PDF]

Clin Neurophysiol Pract
Plensäll T, Liik M, Pogosean A, Eriksson A, Garrett M, Olszowy J, Jackmann S, Punga AR.   +7 more
europepmc   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Chronic Migraine Resistance: A Case Report Highlights an Overlooked Factors in Family Medicine Clinics. [PDF]

Healthcare (Basel)
Alshareef MH.
europepmc   +1 more source

Identification of Copy Number Variants as a Suspected Cause of Cerebral Small Vessel Disease

Clinical Genetics, EarlyView.
Whole‐exome sequencing of 111 patients with suspected familial cerebral small vessel disease (CSVD) identified novel copy number variants in four patients across NOTCH3, LMNB1, and COL4A2, using bioinformatic and molecular techniques. These validated CNVs suggest structural variation is an underrecognized potential causal contributor to monogenic CSVD ...
Solomon K. Guyler, Neven Maksemous, Rodney A. Lea, Robert A. Smith, Heidi G. Sutherland, Lyn R. Griffiths   +5 more
wiley   +1 more source

Anti-CGRP Monoclonal Antibodies in Chronic Migraine: A Position Statement of the Brazilian Academy of Headache and Orofacial Pain. [PDF]

Cureus
Krymchantowski A, Júnior HMDS, Silva-Néto RP, Jevoux C, Costa ALC, Bordini CA, De Vasconcelos CAC, Goncalves DG, Grossi D, Piovesan É, Dach F, Rezende Filho F, Pereira Júnior F, Fortini I, Barbosa J, Marquez JO, Stechman Neto J, Stuginski Barbosa J, Bruscky I, Pinto Vidor L, Silva Lopes L, Queiroz LP, Bigal M, Arruda MA, Bruno M, Silva MT, Pimentel MLV, Beiral Hammerle M, Pizzo R, Matas SLA, Novaretti T, Grassi V, Bastos V.   +32 more
europepmc   +1 more source

Botulinum toxin for chronic migraine. [PDF]

J Neural Transm (Vienna)
Paracka L, Dressler D.
europepmc   +1 more source

Vertigo and dizziness syndromes in children and adolescents: Clinical presentation and diagnostic pathway

Developmental Medicine &Child Neurology, EarlyView.
This study characterized 519 children and adolescents with vertigo using clinical, diagnostic, imaging, quality‐of‐life, and demographic data, identifying vestibular migraine as the most frequent diagnosis, followed by functional dizziness and recurrent vertigo of childhood.
Doreen Huppert, Ralf Strobl, Andreas Zwergal, Florian Heinen, Michaela V. Bonfert, Marius Näher, Anna Huppert, Filipp M. Filippopulos   +7 more
wiley   +1 more source