Results 171 to 180 of about 1,734,152 (292)

Long-term neuromuscular alterations during botulinum toxin treatment for chronic migraine. [PDF]

Clin Neurophysiol Pract
Plensäll T, Liik M, Pogosean A, Eriksson A, Garrett M, Olszowy J, Jackmann S, Punga AR.   +7 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Anti-CGRP Monoclonal Antibodies in Chronic Migraine: A Position Statement of the Brazilian Academy of Headache and Orofacial Pain. [PDF]

Cureus
Krymchantowski A, Júnior HMDS, Silva-Néto RP, Jevoux C, Costa ALC, Bordini CA, De Vasconcelos CAC, Goncalves DG, Grossi D, Piovesan É, Dach F, Rezende Filho F, Pereira Júnior F, Fortini I, Barbosa J, Marquez JO, Stechman Neto J, Stuginski Barbosa J, Bruscky I, Pinto Vidor L, Silva Lopes L, Queiroz LP, Bigal M, Arruda MA, Bruno M, Silva MT, Pimentel MLV, Beiral Hammerle M, Pizzo R, Matas SLA, Novaretti T, Grassi V, Bastos V.   +32 more
europepmc   +1 more source

Targeting peroxynitrite production in a model of persistent temporomandibular disorder comorbid with migraine

British Journal of Pharmacology, EarlyView.
Background and Purpose The persistence of temporomandibular disorders (TMDs), particularly myogenous, in a person with migraine can lead to exacerbated clinical outcomes and limited response to treatment. The pro‐nociceptive reactive nitroxidative species, peroxynitrite, is involved in migraine mechanisms, but little is known of its role in this ...
Simon Akerman, Ana Belen Salinas‐Abarca, Wei Guo, Daniela Salvemini, Marcela Romero‐Reyes   +4 more
wiley   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Slow Diaphragmatic Breathing for Chronic Migraine Prevention and Treatment: A Case Report. [PDF]

Reports (MDPI)
Bentley TGK, D'Andrea-Penna GM, Hightower EL.   +2 more
europepmc   +1 more source

Identification of Copy Number Variants as a Suspected Cause of Cerebral Small Vessel Disease

Clinical Genetics, EarlyView.
Whole‐exome sequencing of 111 patients with suspected familial cerebral small vessel disease (CSVD) identified novel copy number variants in four patients across NOTCH3, LMNB1, and COL4A2, using bioinformatic and molecular techniques. These validated CNVs suggest structural variation is an underrecognized potential causal contributor to monogenic CSVD ...
Solomon K. Guyler, Neven Maksemous, Rodney A. Lea, Robert A. Smith, Heidi G. Sutherland, Lyn R. Griffiths   +5 more
wiley   +1 more source

Botulinum toxin for chronic migraine. [PDF]

J Neural Transm (Vienna)
Paracka L, Dressler D.
europepmc   +1 more source

Static Otolith Signals Reflect Clinical Course in Acute Vestibular Neuritis

Clinical Otolaryngology, EarlyView.
ABSTRACT Objectives To investigate how static and dynamic utricular functions differentially correlate with dizziness symptoms and quality of life (QoL) recovery in patients with acute vestibular neuritis (VN). Design Prospective observational study with 1‐week and 1‐month follow‐up assessments. Setting Tertiary referral centre. Participants Twenty‐six
Seo‐Young Choi, Jae‐Hwan Choi, Hyun Sung Kim, Kwang‐Dong Choi   +3 more
wiley   +1 more source