Results 81 to 90 of about 2,830,257 (398)
Refractory Migraine and Chronic Migraine: Pathophysiological Mechanisms [PDF]
Headache: The Journal of Head and Face Pain, 2008 Migraine is a complex disorder of the brain whose mechanisms are only now being unravelled. It is common, disabling, and economically costly. Brain imaging has suggested a role for the brainstem. While the disorder is almost certainly inherited, the degree to which this contributes to a treatment refractory state is not clear.
Peter J, Goadsby, Richard, Hargreaves
openaire +3 more sources
Advanced Science, EarlyView.Plasma proteomics is leveraged to decode the biological underpinnings of chronic widespread pain. A nested machine learning framework integrates proteomic signatures, prospective outcomes, and Mendelian randomization to uncover 18 causal proteins.
Li Chen +16 more
wiley +1 more source
Scientific Reports, 2023 To evaluate whether preventive treatment can modify endothelial and oxidative biomarkers of vascular disease risk in patients with high-frequency episodic and chronic migraine.
Cristina González Mingot +10 more
doaj +1 more source
Headache, 2020 To evaluate the efficacy, tolerability, and safety of eptinezumab 100 and 300 mg compared with placebo in patients with the dual diagnosis of chronic migraine (CM) and medication‐overuse headache (MOH).
H. Diener +10 more
semanticscholar +1 more source
Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Advanced Science, EarlyView.In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang +16 more
wiley +1 more source
Patient self rated pain: headache versus migraine a retrospective chart review
Head & Face MedicineBackground The International Classification of Headache Disorders (ICHD-3) uses moderate or severe pain intensity in the diagnostic criterion for migraine.
Elizabeth Toigo +4 more
doaj +1 more source
Self-medication with over-the-counter analgesics : a survey of patient characteristics and concerns about pain medication [PDF]
, 2019 Pain is a common reason for self-medication with over-the-counter (OTC) analgesics. However, this self-treating population has remained largely uncharacterized.
Adriaens, Els +10 more
core +2 more sources
Stromal Cell‐Mast Cell Communication Orchestrates Anti‐Viral Immunity in the Meninges
Advanced Science, EarlyView.This study delineates the spatial distribution and postnatal maturation of meningeal mast cells and uncovers their essential role in antiviral immunity. Using genetic models, mast cells are shown to promote CD8⁺ T cell infiltration and viral clearance via IL‐33 receptor signaling and synergistic activation by IL‐33 and ATP from infected stromal cells ...
Qingqing Li +7 more
wiley +1 more source
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2020 Background Migraine is a prevalent, chronic, and multifactorial neurovascular disease. Objectives Our work aimed to investigate if the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness are affected in patients with chronic migraine
Dalia M. Labib +4 more
doaj +1 more source
Cathodal Occipital tDCS is unable to modulate The Sound Induced Flash Illusion in migraine [PDF]
, 2019 Migraine is a highly disabling disease characterized by recurrent pain.Despite an intensive effort, mechanisms of migraine pathophysiology, still represent an unsolved issue.
Filippo Brighina +6 more
core +1 more source