Results 31 to 40 of about 4,918 (154)

Human STAT1 gain-of-function iPSC line from a patient suffering from chronic mucocutaneous candidiasis

Stem Cell Research, 2020
Chronic mucocutaneous candidiasis (CMC) is a disease that is characterized by susceptibility to chronic or recurrent infections with Candida spp. due to mutations affecting mainly the IL-17 signaling of T-Cells. The most common etiologies of CMC are gain-
Kathrin Haake, Tim Wüstefeld, Sylvia Merkert, Doreen Lüttge, Gudrun Göhring, Bernd Auber, Ulrich Baumann, Nico Lachmann   +7 more
doaj   +1 more source

Approach to a child with primary immunodeficiency made simple

Indian Dermatology Online Journal, 2017
Primary immunodeficiency disorders (PIDs) are a group of disorders affecting the capability to fight against infection. These include defects in T cells and B cells affecting cell-mediated and humoral immunity, respectively, combined humoral and cell ...
Dhrubajyoti Sharma, Ankur K Jindal, Amit Rawat, Surjit Singh   +3 more
doaj   +1 more source

Nail Disorders in Systemic Conditions

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail findings in children can be indicative of an underlying systemic disease. Many of these findings are seen in multiple entities and are not specific to one disease. The importance of specifically examining for these nail changes cannot be overstated.
Jane Sanders Bellet
wiley   +1 more source

STAT1 gain-of-function in 12 Moroccan patients: Clinical and genetic insightsSTAT1 GOF in Moroccan patients [PDF]

Journal of Human Immunity
STAT1 gain-of-function mutations cause chronic mucocutaneous candidiasis and broad immune dysregulation, yet African data are limited. In a Moroccan cohort, Baghad et al.
Bouchra Baghad, Ibtihal Benhsaien, Fatima-zahra El Fatoiki, Hind Ouair, Abderrahmane Moundir, Abderrahmane Errami, Maha Soussi-Abdellaoui, Mélanie Migaud, Jean-Laurent Casanova, Anne Puel, Jalila El Bakkouri, Ahmed Aziz Bousfiha, Soumiya Chiheb, Fatima Ailal   +13 more
doaj   +1 more source

Chronic mucocutaneous candidiasis and oesophageal cancer [PDF]

Medical Mycology, 2008
Chronic mucocutaneous candidiasis (CMC) is often accompanied by endocrine or inflammatory disorders. The association of CMC with squamous cell carcinoma of the oral cavity or oesophagus have been described in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Rosa, D.D., Pasqualotto, A.C., Denning, D.W.; id_orcid 0000-0001-5626-2251   +2 more
openaire   +3 more sources

Systemic Treatment of Psoriasis: Current Evidence on Efficacy and Safety

The Journal of Dermatology, EarlyView.
ABSTRACT Systemic treatments for moderate‐to‐severe plaque psoriasis have been advanced from broad immunosuppressants up to agents more selectively targeting cytokines, cytokine receptors, or intracellular signaling. The current systemic treatments mainly consist of conventional systemic agents, biologics targeting tumor necrosis factor (TNF)‐α ...
Teppei Hagino, Naoko Kanda
wiley   +1 more source

Lymphadenitis caused by Purpureocillium lilacinum in a patient with CARD9 deficiency

Medical Mycology Case Reports, 2023
We hereby make the first report of a case of mycosis caused by Purpureocillium lilacinum in CARD9 deficiency. A 40-year-old woman complained of lymph node swellings in the left cervical area.
Hidetaka Majima, Yuzaburo Inoue, Yuichiro Otsuka, Takashi Yaguchi, Akira Watanabe, Katsuhiko Kamei   +5 more
doaj   +1 more source

Autosomal Dominant Hyper‐IgE Syndrome Patients Retain IL10‐Producing preTh17‐Cells That Are Activated by Opportunistic Pathogens and Support IgE Production

Allergy, EarlyView.
IL‐10 producing CCR6+Th‐cells are central memory T‐cells that express ROR‐γt and differentiate to Th17‐cells via an autocrine loop of STAT3‐activating cytokines (preTh17). STAT3‐deficient AD‐HIES patients lack Th17‐ and Tfh17‐cells but retain preTh17‐ and Th1/17‐cells.
Giorgia Moschetti, Chiara Vasco, Francesca Clemente, Paola Larghi, Sara Maioli, Edoardo Scarpa, Elena Carelli, Nadia Pulvirenti, Maria Lucia Sarnicola, Mariacristina Crosti, Manal Bel Imam, Willem van de Veen, Loris Rizzello, Sergio Abrignani, Lucia A. Baselli, Rosa Maria Dellepiane, Maria Carrabba, Giovanna Fabio, Jens Geginat   +18 more
wiley   +1 more source

Cyclophosphamide is associated with long‐term treatment‐free remission in patients with pemphigus

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objective Pemphigus treatment has seen significant advancements, yet long‐term remission remains a challenge. Comparative data on the long‐term effectiveness of available therapies are limited. We compared 10‐year relapse rates in pemphigus patients treated with azathioprine or cyclophosphamide plus high‐dose IV corticosteroids ...
Bettina Santler, Simon Lüdtke, Lena Dietze, Marie Schiffmann, Dominik Straube, Jan Ehrchen   +5 more
wiley   +1 more source

A CASE REPORT OF CHRONIC MUCOCUTANEOUS CANDIDIASIS IN IRAN [PDF]

Iranian Journal of Public Health, 1991
A case of chronic mucocutaneous candidiasis due to Candida albicans in a 13 yr-old boy is reported. Evaluation of cell mediated immunity revealed cutaneous anergy to PPD and low level of T-Lymphocytes B-Cell count and immunoglobulin G (IgG) were ...
M. Moghaddami, M. Emami, P. Toosi, L. Nabai   +3 more
doaj   +1 more source