Results 41 to 50 of about 4,918 (154)

Gastrointestinal manifestations in autoimmune polyendocrinopathy-candidiasisectodermal dystrophy (APECED) patient: major effect on treatment and prognosis

Endocrinology, Diabetes & Metabolism Case Reports, 2023
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare autosomal recessive inherited syndrome caused by mutations in autoimmune regulator (AIRE) gene. The three clinical components of this syndrome are mucocutaneous candidiasis,
Taieb Ach, Ben Yamna Hadami, Nadia Ghariani, Randa Said ElMabrouk, Asma Ben Abdelkrim, Maha Kacem, Mohamed Denguezli, Koussay Ach   +7 more
doaj   +1 more source

When to consider an inborn error of immunity: clues for physicians

Internal Medicine Journal, EarlyView.
Abstract The term inborn errors of immunity (IEIs) refers to the rapidly expanding group of genetic disorders causing dysregulation of the immune system. With improved genetic testing in recent years, the number of defined IEIs and their range of phenotypic presentations has grown vastly, with more than 550 IEIs now described.
Meera Thangarajah, Lucinda J. Berglund
wiley   +1 more source

Expert consensus on oral management in autoimmune bullous diseases, erythema multiforme and SJS/TEN

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This international Delphi study achieved expert consensus on 58 statements guiding the management of oral involvement in autoimmune bullous diseases, erythema multiforme and SJS‐TEN. The recommendations emphasize multidisciplinary care, oral hygiene and tailored topical, systemic and inpatient oral management.
Shalini Nayee, Molly Harte, Saskia Ingen‐Housz‐Oro, Milad Ameri, Sarah Walsh, Pascal Joly, Michael Ardern‐Jones, Vlaho Brailo, Marie‐Charlotte Brueggen, Christopher Bunker, Barbara Carey, Marco Carrozzo, Ser‐Ling Chua, Daniel Creamer, Donna Culton, Konstantina Delli, Marcio Diniz‐Freitas, Roni Dodiuk‐Gad, Sophie‐Myriam Dridi, Anne‐Laure Ejeil, Lars French, Krisztian Gaspar, Jon Higham, Barbara Horvarth, Esther Hullah, Sabine Jurge, Roddy McMillan, Helen McParland, Dedee Murrell, Martyn Ormond, Ana Poveda‐Gallego, Mahtab Samimi, Enno Schmidt, Martina Shephard, Tom Sollecito, Jennifer Taylor, Soner Uzun, Skaidra Valiukeviciene, Amanda Willis, Jane Setterfield   +39 more
wiley   +1 more source

An Extraordinary Case of Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED) Syndrome Misdiagnosed as Juvenile Idiopathic Arthritis on Admission

Case Reports in Immunology, 2023
Background. APECED is a syndrome characterized by autoimmune polyendocrinopathy, candidiasis, and ectodermal dystrophy. The most observed clinical findings are chronic mucocutaneous candidiasis, hypoparathyroidism, and autoimmune adrenal insufficiency ...
Gulcin Aytac, Burcu Guven, Ilyas Aydin, Ezgi Topyildiz, Ayca Aykut, Asude Durmaz, Neslihan Edeer Karaca, Guzide Aksu, Necil Kutukculer   +8 more
doaj   +1 more source

Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy

Frontiers in Pediatrics, 2021
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), also known as autoimmune polyglandular syndrome type-1 (APS-1), is a rare monogenic autoimmune disease caused by loss-of-function mutations in the autoimmune regulator (AIRE) gene ...
Elise M. N. Ferré, Monica M. Schmitt, Michail S. Lionakis   +2 more
doaj   +1 more source

Early recognition of the APECED rash can accelerate the diagnosis of APECED

Clinical Immunology Communications
Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED) is a monogenic autoimmune disease most often resulting from biallelic loss-of-function variants in the autoimmune regulator (AIRE) gene.
Elise M.N. Ferré, Chyi-Chia R. Lee, Michail S. Lionakis   +2 more
doaj   +1 more source

Neonatal Bloodstream Infections: A Narrative Review on Diagnostic and Therapeutic Challenges and Prospects in Developing Countries

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Bloodstream infections (BSIs) pose a significant global health challenge, particularly in developing countries. Neonates are highly vulnerable due to underdeveloped immune systems and immature physical barriers, a risk amplified by poor hygiene and limited healthcare access in low‐ and middle‐income countries (LMICs), leading to an ...
Alex Odoom, Abdul‐Halim Osman, Onyansaniba K. Ntim, Fleischer C. N. Kotey, Eric S. Donkor   +4 more
wiley   +1 more source

Successful Treatment of Chronic Mucocutaneous Candidiasis Caused by Azole-Resistant Candida albicans with Posaconazole

Clinical and Developmental Immunology, 2011
Refractory or recurrent infections of skin, nails, and the mucous membranes are clinical signs of chronic mucocutaneous candidiasis, frequently associated with immunological defects. Here we describe a 39-years-old female patient, with familial CMC, that
Davide Firinu, Orietta Massidda, Maria Maddalena Lorrai, Loredana Serusi, Monica Peralta, Maria Pina Barca, Paolo Serra, Paolo Emilio Manconi   +7 more
doaj   +1 more source

Oral lichen planus: study of 21 cases [PDF]

Anais Brasileiros de Dermatologia, 2015
BACKGROUND: Lichen planus is considered to be the most common dermatological disease involving the oral mucosa. OBJECTIVE: To investigate the profile, clinical features, and the presence of dysplasia and candidiasis in patients with oral lichen planus ...
Juliana Tristão Werneck, Taiara de Oliveira Costa, Christian Abreu Stibich, Cristhiane Almeida Leite, Eliane Pedra Dias, Arley Silva Junior   +5 more
doaj   +2 more sources

From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Recent and limited evidence indicates that oral candidiasis can disseminate Candida albicans throughout the body, leading to invasive candidiasis, such as candidemia, a life‐threatening infection. Considering antifungal resistance and global outbreaks of emergent non‐albicans Candida and related yeasts, murine models help understand dissemination ...
Julia Robledo Jerez, Marcella Vieira Ambrosio, Marcela Eduarda Olegario Fernandes, Ewerton Garcia de Oliveira Mima   +3 more
wiley   +1 more source