Results 171 to 180 of about 399,367 (396)

Preleukemia: one name, many meanings. [PDF]

, 2017
Definition of preleukemia has evolved. It was first used to describe the myelodysplastic syndrome (MDS) with a propensity to progress to acute myeloid leukemia (AML). Individuals with germline mutations of either RUNX1, CEBPA, or GATA2 can also be called
Koeffler, HP, Leong, G
core  

Efficacy, Safety, Pharmacokinetics, and Immunogenicity of ABBV‐154 in Adults With Glucocorticoid‐Dependent Polymyalgia Rheumatica: A Phase 2, Randomized, Double‐Blind, Placebo‐Controlled Trial

Arthritis &Rheumatology, EarlyView.
Objective An unmet need exists for glucocorticoid‐sparing treatments for patients with polymyalgia rheumatica (PMR). The antibody‐drug conjugate ABBV‐154 comprises adalimumab conjugated to a glucocorticoid receptor modulator. We evaluated ABBV‐154 versus placebo in patients with glucocorticoid‐dependent PMR.
Robert F. Spiera, Valerie Devauchelle‐Pensec, Claire E. Owen, Federico Díaz‐González, Tsutomu Takeuchi, Edit Drescher, Jaclyn Anderson, Dilek Arikan, Ronilda D'Cunha, Julie Parmentier, Denise T. Kruzikas, Weihan Zhao, Yang Yang, Karen Stellpflug, Frank Buttgereit   +14 more
wiley   +1 more source

Therapeutic Response of Blastic Crisis of Chronic Myeloid Leukemia (CML) [PDF]

, 1978
G Casirola, G Ippoliti, Rosangela Invernizzi, G Marini   +3 more
openalex   +1 more source

Investigating the p53 Codon 72 Polymorphism in Patients with Chronic Myeloid Leukemia in Isfahan, Iran

مجله دانشکده پزشکی اصفهان, 2015
Background: The p53 tumor suppressor gene plays important roles in genomic stability. A common polymorphism at codon 72 in the p53 gene has been associated with increased risk for lung, oral, prostate, breast and colorectal cancers.
Mehdi Nikbakht-Dastjerdi, Fatemehsadat Mirabutalebi, Zeinab Ebrahimi   +2 more
doaj  

Cytogenetic events after bone marrow transplantation for chronic myeloid leukemia in chronic phase [PDF]

, 1988
CK Arthur, JF Apperley, AP Guo, F. Rassool, LM Gao, JM Goldman   +5 more
openalex   +1 more source

Artificial intelligence modelling of tyrosine kinase inhibitors at risk of malabsorption and bioavailability‐enhancing strategies

British Journal of Clinical Pharmacology, EarlyView.
Aims The study aims to predict and improve the absorption of tyrosine kinase inhibitors (TKIs) in patients with malabsorption issues, particularly those who have undergone bariatric surgery or are using proton‐pump inhibitors. The research involves 2 main components: the development of an artificial intelligence (AI) model to identify TKIs that are ...
Daan W. Huntjens, Olivier J. M. Béquignon, Stefanie D. Krens, Mark Löwenberg, Martine E. D. Chamuleau, Remco J. Molenaar, Anita M. G. Kramers, Marianne A. Kuijvenhoven, Imke H. Bartelink   +8 more
wiley   +1 more source

Randomization in phase II trials: No exemption based on sample size

British Journal of Clinical Pharmacology, EarlyView.
Conducting randomized clinical trials (RCTs) is challenging. For this reason, in earlier phases of drug development and rare diseases with limited sample sizes, there is a tendency to omit control groups and to replace them with historical information for perceived feasibility arguments.
Theodor Framke, Gernot Beutel, Arnold Ganser, Armin Koch, Anika Großhennig   +4 more
wiley   +1 more source

Philadelphia-positive chronic myeloid leukemia with a chromosome 22 breakpoint outside the breakpoint cluster region [published erratum appears in Blood 1988 Jan;71(1):272] [PDF]

, 1987
Licia Selleri, Franco Narni, Giovanni Emilia, A Colò, Patrizia Zucchini, Donatella Venturelli, Amedea Donelli, U Torelli, Giuseppe Torelli   +8 more
openalex   +1 more source

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

Restoration of responsiveness of chronic myeloid leukemia granulocyte- macrophage colony-forming cells to growth regulation in vitro following preincubation with prostaglandin E [PDF]

, 1983
LM Pelus, E Gold, S Saletan, M Coleman
openalex   +1 more source