Results 161 to 170 of about 113,185 (266)

Therapeutic Targets for Overcoming BCR::ABL1 Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia. [PDF]

Oncol Res
Tsubaki M, Matsuo T, Komori R.
europepmc   +1 more source

Successful allo‐hematopoietic stem cell transplantation using washed hematopoietic stem cells in a pediatric patient complicated by acute myeloid leukemia and severe anaphylaxis to blood product

Pediatric Investigation, EarlyView.
Jieyu Tian, Guanghua Zhu, Maoquan Qin, Chenguang Jia, Shuxuan Ma, Bin Wang, Yanhui Luo   +6 more
wiley   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Neoplastic Risk in Patients With Klinefelter Syndrome

Andrology, EarlyView.
ABSTRACT Background Besides gonadal involvement (hypogonadism, male factor infertility, and testicular hypotrophy), patients with Klinefelter syndrome (KS) may suffer from several extra‐gonadic complications, including neoplastic events. Objective The aim of this review is to summarize all major clinical evidence dealing with the association between KS
Andrea Graziani, Giuseppe Grande, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +4 more
wiley   +1 more source

Myeloproliferative neoplasms with concomitant chronic myeloid leukemia are associated with TKI resistance and poor outcomes. [PDF]

Leukemia
Gagnon LL, Duminuco A, Stagno F, Sobas M, Fominykh M, Virchis A, Nicolini FE, Hildt J, Bentley H, Godfrey AL, Shih LY, Chee A, Mead A, Lewandowski K, Sobieralski P, Hannah G, Reyal Y, Cummin T, Piszcz J, Yip K, Frewin R, Narayanan S, Rahman D, Ajayi A, Cervi P, Byrne J, Taylor T, Lebowa W, Pavlu J, Arami S, Ceesay M, Chraniuk D, Delage R, Condorelli A, Santana C, Radia DH, de Lavallade H, Milojkovic D, Harrison C, Harrington P.   +39 more
europepmc   +1 more source

Identification of Coagulation Phenotypes Using Viscoelastic and Conventional Assays During Veno‐Venous Extracorporeal Membrane Oxygenation: A Hierarchical Clustering Analysis

Artificial Organs, EarlyView.
Hierarchical clustering of viscoelastic and conventional coagulation parameters identified three distinct phenotypes in V‐V ECMO patients, revealing substantial APTT–CK‐R discordance and highlighting the value of TEG‐derived markers for detecting coagulopathy not captured by standard monitoring.
Daisuke Irimada, Yudai Iwasaki, Yusuke Takei, Moe Oyama, Ami Tanaka, Shinichi Yamaguchi, Naoya Kobayashi, Daisuke Konno, Takuya Shiga, Masanori Yamauchi   +9 more
wiley   +1 more source

Painful fissured plaques on the palms and soles in a patient with chronic myeloid leukemia. [PDF]

JAAD Case Rep
Shet PA, Sompayrac A, Patel JD, Dahle SE, Isseroff RR.   +4 more
europepmc   +1 more source

Long‐Term Safety and Efficacy of Obeticholic Acid in Patients With Primary Biliary Cholangitis: Final Results of the POISE Long‐Term Safety Extension

Alimentary Pharmacology &Therapeutics, EarlyView.
In the POISE open‐label extension, patients with primary biliary cholangitis with inadequate response or intolerance to ursodeoxycholic acid received long‐term obeticholic acid (OCA) treatment. Findings demonstrated a safety profile consistent with the known characteristics of OCA, with no unexpected safety signals, while supporting sustained efficacy ...
Christopher L. Bowlus, Frederik Nevens, Kris V. Kowdley, Alan Bonder, Thomas Capozza, Jing Li, Radhika Nair, Michael Trauner, David E. Jones   +8 more
wiley   +1 more source

BCR-ABL1 Drives Transcriptional Reprogramming of Chronic Myeloid Leukemia Cells for Immune Evasion Through C/EBPβ. [PDF]

MedComm (2020)
Lu X, Fang H, Liu Y, Liu C, Fang X, Matsunaga A, Mori SF, Zhang T, Wang G, Zhou GI, Yu M, Ding H, Cortes J, Cheng B, Hu T.   +14 more
europepmc   +1 more source

The association of thrombocytopenia with haematological malignancy

British Journal of Haematology, EarlyView.
This review article discusses the interplay of immune dysregulation, clonality, and immunosuppressive therapies in immune thrombocytopenia and how this links to the risk of misattribution versus the development of haematological malignancy. Unresolved questions and directions for future research are also discussed. Isolated thrombocytopenia is commonly
Abi Vijenthira, Henrik Frederiksen, Michelle Sholzberg   +2 more
wiley   +1 more source