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Optimal treatment strategy with nilotinib for patients with newly diagnosed chronic‐phase chronic myeloid leukemia based on early achievement of deep molecular response (MR4.5): The phase 2, multicenter N‐Road study
, 2020 Kaichi Nishiwaki, Keiji Sugimoto, Shigehisa Tamaki, Junichi Hisatake, Hisayuki Yokoyama, Tadahiko Igarashi, Atsushi Shinagawa, Takeaki Sugawara, Satoru Hara, Kazuhisa Fujikawa, Seiichi Shimizu, Toshiaki Yujiri, Arinobu Tojo, Hisashi Wakita +13 moreopenalex +1 more sourceNilotinib versus imatinib for newly diagnosed chronic myeloid leukemia.
New England Journal of Medicine, 2010 G. Saglio, Dong-Wook Kim, S. Issaragrisil, P. le Coutre, G. Étienne, C. Lobo, R. Pasquini, R. Clark, A. Hochhaus, T. Hughes, N. Gallagher, A. Hoenekopp, M. Dong, A. Haque, R. Larson, H. Kantarjian +15 moresemanticscholar +1 more sourceSemi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.Abstract
Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.Neha Thakre, Corinna Maier, Jiuhong Zha, Benjamin Engelhardt, Johannes E. Wolff, Sven Mensing +5 morewiley +1 more sourceSingle-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia
Nature Medicine, 2017 Alice Giustacchini, S. Thongjuea, Nikolaos Barkas, P. Woll, B. Povinelli, Christopher A. G. Booth, P. Sopp, Ruggiero Norfo, A. Rodriguez-Meira, N. Ashley, Lauren Jamieson, P. Vyas, K. Anderson, Å. Segerstolpe, H. Qian, U. Olsson‐Strömberg, S. Mustjoki, R. Sandberg, S. Jacobsen, A. Mead +19 moresemanticscholar +1 more sourceDisease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.ABSTRACT
Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...Medhat M. Said, Job R. Schippers, Leila Atmowihardjo, Yingxue Li, Mick S. van der Plas, Harm J. Bogaard, Lieuwe D. J. Bos, Ron A. A. Mathôt, Jurjan Aman, Eleonora L. Swart, Imke H. Bartelink +10 morewiley +1 more sourceSupplementary Material for: Evaluating the Safety of Combining Tyrosine Kinase Inhibitors with Anticoagulants in Chronic Myeloid Leukemia: A Systematic Review
figshare admin karger, Gameil A., Ghasoub R., Nasrin Jafari, Shafei L., Benkhadra M., Laws S., H. A. Hamad, Sabet I., Milojkovic D., Fernyhough L. +10 moreopenalex +1 more source