Results 91 to 100 of about 487,389 (311)

Chronic intestinal pseudo-obstruction

World Journal of Gastroenterology, 2008
Chronic intestinal pseudo-obstruction (CIPO) is a severe digestive syndrome characterized by derangement of gut propulsive motility which resembles mechanical obstruction, in the absence of any obstructive process. Although uncommon in clinical practice, this syndrome represents one of the main causes of intestinal failure and is characterized by high ...
ANTONUCCI, ALEXANDRA, Fronzoni L, Cogliandro L, COGLIANDRO, ROSANNA FRANCESCA, Caputo C, DE GIORGIO, ROBERTO, PALLOTTI, FRANCESCA, BARBARA, GIOVANNI, CORINALDESI, ROBERTO, STANGHELLINI, VINCENZO   +9 more
openaire   +3 more sources

Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers

Respiratory Research, 2005
Background Inflammation in the airways and lung parenchyma underlies fixed airway obstruction in chronic obstructive pulmonary disease. The exact role of smoking as promoting factor of inflammation in chronic obstructive pulmonary disease is not clear ...
Willemse Brigitte WM, ten Hacken Nick HT, Rutgers Bea, Postma Dirkje S, Timens Wim   +4 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Long-term exposure to outdoor air pollution and the incidence of chronic obstructive pulmonary disease in a national English cohort. [PDF]

, 2014
OBJECTIVES: The role of outdoor air pollution in the incidence of chronic obstructive pulmonary disease (COPD) remains unclear. We investigated this question using a large, nationally representative cohort based on primary care records linked to hospital
Van Staa, Tjeerd; id_orcid, van Staa, TP, Anderson, HR, Carey, I M, Kent, AJ, Kent, A J, van Staa, T P, Atkinson, R W, Sub Pharmacoepidemiology, Atkinson, RW, Anderson, H R, Pharmacoepidemiology and Clinical Pharmacology, Carey, IM, Cook, DG, Cook, D G   +14 more
core   +1 more source

High urinary desmosine is associated with long-term mortality in patients with COPD

ERJ Open Research, 2023
Changhwan Kim, Yousang Ko, Jae Seung Lee, Chin Kook Rhee, Jin Hwa Lee, Ji-Yong Moon, Seong Yong Lim, Kwang Ha Yoo, Joon Beom Seo, Yeon-Mok Oh, Sang-Do Lee, Yong Bum Park   +11 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Systematic review on inhaled corticosteroid monotherapy and its efficacy and safety in longterm treatment of patients with chronic obstructive pulmonary disease (COPD) [PDF]

--chronic obstructive pulmonary disease,COPD,corticosteroids,systematic review,chronisch obstruktive Lungenerkrankung,COPD,Kortikosteroid,systematischer ...
Wasem, Jürgen, Kossmann, Beate, Niebuhr, Dea, Buchberger, Barbara, Neumann, Anja   +4 more
core  

Pilot study of losartan for pulmonary hypertension in chronic obstructive pulmonary disease. [PDF]

, 2005
BACKGROUND: Morbidity in COPD results from a combination of factors including hypoxia-induced pulmonary hypertension, in part due to pulmonary vascular remodelling. Animal studies suggest a role of angiotensin II and acute studies in man concur.
Shakur, B Haleema, Paul J Robinson, Morrell, Nicholas W, Peter G Phillips, Shakur B Haleema, Matthew A Higham, B Haleema Shakur, Robinson Paul J, Nicholas W Morrell, Ray J Beddoes, Robinson, Paul J, Beddoes, Ray J, Beddoes Ray J, Higham, Matthew A, Phillips Peter G, Phillips, Peter G, Higham Matthew A, Morrell Nicholas W   +17 more
core   +1 more source