Results 81 to 90 of about 487,389 (311)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Breathing and Breathlessness: Chronic Obstructive Pulmonary Disease in Uruguay [PDF]

, 2013
An increasingly common part of being human is living with chronic health problems for which management over time, and not cure, is the goal of medical treatment.
Wainwright, M., WAINWRIGHT, MEGAN,JULIE
core  

Long-acting beta2-agonists for chronic obstructive pulmonary disease.

, 2013
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a respiratory disease that causes progressive symptoms of breathlessness, cough and mucus build-up.
Walters, JA, Chris Mavergames, Kew, KM, Mavergames, C, Kayleigh M Kew, Julia AE Walters   +5 more
core   +1 more source

Reporting participation rates in studies of non-pharmacological interventions for patients with chronic obstructive pulmonary disease: a systematic review [PDF]

, 2012
Background Pulmonary rehabilitation (PR) and self-management (SM) support programmes are effective in the management of patients with chronic obstructive pulmonary disease (COPD), but these interventions are not widely implemented in routine care.
SOHANPAL, R, Hooper Richard, Rachel Hames, Richard Hooper, Ratna Sohanpal, Taylor, S, Hames, R, Sohanpal Ratna, Taylor Stephanie, Priebe Stefan, Priebe, S, Stefan Priebe, Stephanie Taylor, Hames Rachel, Hooper, R   +14 more
core   +1 more source

Deterioration of Respiratory Symptoms in Uncontrolled CPFE: A Case Report

Jurnal Respirasi
Introduction: Chronic obstructive pulmonary disease (COPD) has a global impact on health and increases healthcare costs. Combined pulmonary fibrosis and emphysema (CPFE) combines interstitial lung disease (ILD) and emphysema.
Frans Raffael, Amira Permatasari Tarigan
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease [PDF]

, 2008
RATIONALE:Abnormal inflammation and accelerated decline in lung function occur in patients with chronic obstructive pulmonary disease (COPD). Human sirtuin (SIRT1), an antiaging and antiinflammatory protein, is a metabolic NAD(+)-dependent protein ...
Rajendrasozhan, Saravanan, Kinnula, Vuokko L, Rahman, Irfan, Yang, Se-Ran   +3 more
core   +1 more source

Call to action: improving primary care for women with COPD

npj Primary Care Respiratory Medicine, 2017
In this perspective-based article, which is based on findings from a comprehensive literature search, we discuss the significant and growing burden of chronic obstructive pulmonary disease in women worldwide.
Ioanna Tsiligianni, Miguel Román Rodríguez, Karin Lisspers, Tze LeeTan, Antonio Infantino   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Changes in plasma levels of B-type natriuretic peptide with acute exacerbations of chronic obstructive pulmonary disease.

, 2014
Background: Elevated plasma B-type natriuretic peptide (BNP) levels and their association with heart failure have been reported in subjects with acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
Oga, T, Nishimura, K, Nishimura, T, Onishi, K, Jones, PW, Hasegawa, Y   +5 more
core   +1 more source