Results 61 to 70 of about 2,297,875 (300)

Comparative Study on the Quality of Life of Chronic Obstructive Pulmonary Disease Patients [PDF]

Objective: The main goal of this study is to compare the Quality of Life (QoL) of Chronic Obstructive Pulmonary Disease (COPD) patients between three different regions: the United Arab Emirates (UAE), the United Kingdom (UK) and Morocco. Another aim of
Bihi, Imane Ben
core   +6 more sources

Prevalence of depression and anxiety in patients with chronic obstructive pulmonary disease and their association with psychosocial outcomes: A cross-sectional study from Pakistan

SAGE Open Medicine, 2021
Objectives: Chronic obstructive pulmonary disease contributes to substantial health and economic burden worldwide. Co-morbid depression and anxiety are highly prevalent in patients with chronic obstructive pulmonary disease.
Muhammad Omair Husain, Imran B Chaudhry, Amy Blakemore, Suleman Shakoor, Muhammad Ali Husain, Steven Lane, Tayyeba Kiran, Farhat Jafri, Rakhshi Memon, Maria Panagioti, Nusrat Husain   +10 more
doaj   +1 more source

Barriers to adherence to home-based pulmonary rehabilitation among patients with chronic obstructive pulmonary disease in Iran: a descriptive qualitative study

BMJ Open, 2023
Objectives Chronic obstructive pulmonary disease is a chronic disease with numerous complications. Therefore, its effective management depends on home-based pulmonary rehabilitation.
Ramin Sami, Kobra Salehi, Marzieh Hashemi, Shila Haghighat, Vajihe Atashi   +4 more
doaj   +1 more source

Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: The ISOLDE trial [PDF]

, 2000
Objectives To determine the effect of long term inhaled corticosteroids on lung function, exacerbations, and health status in patients with moderate to severe chronic obstructive pulmonary disease.
Spencer, S, Spencer, Sally, Calverley, Peter MA, Jones, Paul W, Jones, PW, Maslen, TK, Burge, P Sherwood, Burge, PS, Calverley, PMA, Maslen, T K, Anderson, JA, Spencer, Sally; id_orcid, Anderson, Julie A   +12 more
core   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Evaluation of Arterial Stiffness in Patients with Bronchial Asthma and Co-Existent Chronic Obstructive Pulmonary Disease

Galician Medical Journal, 2017
The objective of the research was to determine the characteristics of arterial stiffness and cardiovascular risk in patients with co-existence of asthma and chronic obstructive pulmonary disease. Materials and methods.
Kseniia Nazarenko
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial [PDF]

, 2010
Background Acute exacerbations contribute to the morbidity and mortality associated with chronic obstructive pulmonary disease (COPD). This proof-of-concept study evaluates whether intermittent pulsed moxifloxacin treatment could reduce the frequency of ...
Jones, PW, Badenhorst J., Sethi S., Cukier A., Miravitlles, M, Sethi, S, Clancy L., Marlize Schmitt Theron, Bitter-Suermann S., Miravitlles Marc, Bettendorf A., Nadar R., Sanjay Sethi, Queguiner A., Rubinstein, E, Potena A., Naude G., PULSE Study group, Abenhaim N., Schroder-Babo W., Di Bartolo C., null null, Theron, MS, Kroemer B., Ferreyra R., del Campo F., de Oliveira J. A., Wedzicha J. A., Jones P. W., Killian J., Watz H., Millar A., Toubis M., Jadwiga A Wedzicha, Molitor S., Anzueto A., Gebhardt R., Groth G., Sanchez R. P., Peraza R. B., Sharafkhaneh A., Bassaris H., Smith C., Wilson Robert, Merida F. C., Fritscher C., Joubert J., Sethi Sanjay, Llamas F. S., Parada M., Alvarez-Sala L., Rubinstein Ethan, Raz P., Cote C., Vlastos F., Legnani D., Richter K., Menendez R., Barnes N. C., Viljoen J., Hasan S., Lalanne G., Wilson, R, Rubinstein E., Rastogi P., Elliott M., Bolio F. T., Fernandez P., Gaines S., Colberg K., Schaberg T., Harari S., Triot P., Monso E., Nieuwoudt G., Westerhausen U., Paul W Jones, Mans W., O'Connell F., Prins M., Dichmann R., Miravitlles M., Taminau D., Raz M., Ignacio J. M., Plautz M., Jones Paul W, Theron M. S., Zeltser D., Habib M., Kawley F., Jardim J. B., Linnhoff A., Weiler Z., Cutillas J. R., Wedzicha Jadwiga A, Robert Wilson, Barros M., Stockley R., Ethan Rubinstein, Wedzicha, JA, Wilson R., Mahutte C. K., Bugnas B., Littner M., Marc Miravitlles, Luna C., Theron Marlize, Hosp H. A., Pozzi E., Groth J., Rubinstein, Ethan, Wilson, Robert, Theron, Marlize S, Jones, Paul W, Sethi, Sanjay, Miravitlles, Marc, the PULSE Study group, Wedzicha, Jadwiga A   +118 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source