Results 171 to 180 of about 6,002,276 (336)

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Association of single-nucleotide polymorphism with spirometry indices and pulmonary ventilation characteristics in patients with chronic obstructive pulmonary disease

Journal of International Medical Research
Objectives Genome-wide association studies have identified FAM13A as a gene linked to chronic obstructive pulmonary disease. Several single-nucleotide polymorphisms—notably, rs7671167, rs2869967, rs2869966, and rs17014601—are associated with chronic ...
Binh Huy Nguyen, Nhung Thi Cam Tran, Chuong Quoc Ho, Tam Thai Thanh Tran, Hong Ngoc Phan, De Van Tran, Nga Thi Ngoc Pham, Kien Trung Nguyen, Khanh Hoang Pham   +8 more
doaj   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Geographic distribution of asthma and chronic obstructive pulmonary disease hospitalisations in Australia: 2007-08 to 2009-10 [PDF]

, 2013
This report shows how asthma and chronic obstructive pulmonary disease (COPD) hospitalisations vary across Australia. It also examines the association between these hospitalisation rates and socioeconomic status (SES), remoteness and the proportion of

core  

A 4-year trial of tiotropium in chronic obstructive pulmonary disease.

New England Journal of Medicine, 2008
D. Tashkin, B. Celli, S. Senn, D. Burkhart, S. Kesten, S. Menjoge, M. Decramer   +6 more
semanticscholar   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Inflammatory mechanisms in patients with chronic obstructive pulmonary disease.

Journal of Allergy and Clinical Immunology, 2016
P. Barnes
semanticscholar   +1 more source

Recapitulating In Vivo Pharmacokinetics and Size‐Dependent Nanomedicine Delivery in a Microfluidic Platform

Advanced Science, EarlyView.
A microfluidic tumor platform integrates pharmacokinetic flow control, vascular‐like barriers, and 3D tumor spheroids to emulate in vivo drug exposure. The system reproduces dynamic concentration–time profiles and enables size‐dependent nanoparticle transport and efficacy evaluation, providing a predictive framework for assessing nanomedicine ...
Su Jeong Kang, Moon Sup Yoon, Jae Min Lee, Min Jeong Jo, Chae Eun Jin, Dae Hwan Shin   +5 more
wiley   +1 more source

Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease.

New England Journal of Medicine, 1995
L. Aurent, B. Rochard, J. Ordi, M. Ancebo, M. Arc, W. Ysocki, F. Rédéric, L. Ofaso, G. Iorgio, C. Onti, A. Lain, R. Auss, G. Érald, S. Imonneau, S. Alvador, B. Enito, A. Lessandro, G. Asparetto, F. Rançois, L. Emaire, D. Aniel, I. Sabey, Henri Mondor Hospital, France Créteil, F. Lemaire   +24 more
semanticscholar   +1 more source

Beyond PEG: Emerging Polymer Lipid Alternatives for Lipid Nanoparticle (LNP) Formulations

Advanced Science, EarlyView.
This review discusses recent advances in PEG‐alternative LNP designs, including non‐PEG polymers, zwitterionic lipids, and polypeptides. It evaluates how surface‐engineering chemistry influences LNP formation and biological behavior, and highlights current limitations and opportunities of PEG‐alternative LNPs.
Zihnil A. I. Mazrad, Yi Ju, Stephen J. Kent, Colin W. Pouton, Kristian Kempe   +4 more
wiley   +1 more source