Results 51 to 60 of about 541,960 (339)

Adipokines and Associations with Incident Osteoporotic Fracture in Patients with Rheumatoid Arthritis

Arthritis Care &Research, Accepted Article.
Purpose We assessed whether circulating adipokines are associated with incident fractures in patients with rheumatoid arthritis (RA). Methods Three adipokines (adiponectin, leptin, fibroblast growth factor [FGF]‐21) were measured using banked enrollment serum from participants in a longitudinal RA cohort.
Joshua F. Baker, Bryant R. England, Michael D. George, Hannah Brubeck, Brian Sauer, Aleksander Lenert, Punyasha Roul, Geoffrey M. Thiele, Ted R. Mikuls, Katherine D. Wysham   +9 more
wiley   +1 more source

Background of the development of the concept of physical rehabilitation of patients with COPD

Journal of Education, Health and Sport, 2016
The article presents data on the prevalence of chronic obstructive pulmonary disease and economic losses to which it leads. The emphasis is placed on the relevance of developing adequate rehabilitation measures for patients. A special place is devoted to
N. I. Maistruk
doaj   +3 more sources

Clinical Outcomes Of Patients Within The Rheumatoid Arthritis Care Pathway Cohort At a Tertiary Care Integrated Delivery Network: A Comparison To Usual Care

Arthritis Care &Research, Accepted Article.
Objective We aimed to compare clinical outcomes between patients in the Allegheny Health Network rheumatoid arthritis (RA) care pathway and patients receiving usual care. Methods The care pathway initiative implements guideline‐based best practice alongside multi‐disciplinary team‐based care. Clinical and insurance claims data were extracted to compare
Tarun Sharma, Tyson S. Barrett, Teigan Dwyer, Nancy Campbell, Jessica Heintzinger, Ellen Kraemer, Adam Dore, Susan Manzi   +7 more
wiley   +1 more source

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

Modelling the longitudinal measurement of chronic obstructive pulmonary disease outpatient follow-up in the northwestern Ethiopia

Scientific Reports, 2023
Chronic obstructive pulmonary disease is a condition which can be prevented and treated and is characterized by difficulty of breathing that is not entirely curable.
Yoseph Kassa, Habtamu Geremew, Chalachew Gashu   +2 more
doaj   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source

Adoption and adherence to chronic obstructive pulmonary disease GOLD guidelines in a primary care setting

SAGE Open Medicine, 2019
Objectives: Over 380 million people in the world live with chronic obstructive pulmonary disease, and it is the third leading cause of death in the United States. Despite updated guidelines, there may be significant variations in diagnosis and management
Salim Surani, Akshar Aiyer, Stephen Eikermann, Timothy Murphy, Pranav Anand, Joseph Varon, David Vanderheiden, Alamgir Khan, Antonio Guzman   +8 more
doaj   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Nature Genetics, 2018
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are ...
N. Shrine, A. Guyatt, A. Erzurumluoglu, V. Jackson, B. Hobbs, C. Melbourne, C. Batini, K. Fawcett, Kijoung Song, P. Sakornsakolpat, Xingnan Li, Ruth Boxall, N. Reeve, M. Obeidat, J. Zhao, M. Wielscher, S. Weiss, K. Kentistou, J. Cook, B. Sun, Jian Zhou, J. Hui, S. Karrasch, M. Imboden, S. Harris, J. Marten, Stefan Enroth, S. Kerr, I. Surakka, V. Vitart, T. Lehtimäki, R. Allen, P. Bakke, T. Beaty, E. Bleecker, Y. Bossé, C. Brandsma, Zhengming Chen, J. Crapo, J. Danesh, D. Demeo, F. Dudbridge, R. Ewert, C. Gieger, A. Gulsvik, A. Hansell, K. Hao, Joshua D Hoffman, J. Hokanson, G. Homuth, Peter K. Joshi, P. Joubert, C. Langenberg, Xuan Li, Liming Li, Kuang Lin, L. Lind, N. Locantore, J. Luan, A. Mahajan, J. Maranville, A. Murray, D. Nickle, R. Packer, M. Parker, Megan L. Paynton, D. Porteous, Dmitry Prokopenko, D. Qiao, R. Rawal, H. Runz, I. Sayers, D. Sin, Blair H. Smith, M. Soler Artigas, D. Sparrow, R. Tal-Singer, P. Timmers, M. van den Berge, J. Whittaker, P. Woodruff, L. Yerges-Armstrong, O. Troyanskaya, O. Raitakari, M. Kähönen, O. Polašek, U. Gyllensten, I. Rudan, I. Deary, N. Probst-Hensch, H. Schulz, A. James, James F. Wilson, B. Stubbe, E. Zeggini, M. Jarvelin, N. Wareham, E. Silverman, C. Hayward, A. Morris, A. Butterworth, R. Scott, R. Walters, D. Meyers, M. Cho, D. Strachan, I. Hall, M. Tobin, L. Wain   +108 more
semanticscholar   +1 more source