Results 51 to 60 of about 772,617 (344)

Comorbidities of patients in tiotropium clinical trials : comparison with observational studies of patients with chronic obstructive pulmonary disease [PDF]

, 2015
Acknowledgments The authors are fully responsible for all content and editorial decisions made, were involved at all stages of manuscript development, and have approved the final version for publication.
Celli, Bartolome, Metzdorf, Norbert, Miravitlles, Marc, Price, David, Rabe, Klaus F, Schmidt, Hendrik   +5 more
core   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Nature Genetics, 2018
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are ...
N. Shrine, A. Guyatt, A. Erzurumluoglu, V. Jackson, B. Hobbs, C. Melbourne, C. Batini, K. Fawcett, Kijoung Song, P. Sakornsakolpat, Xingnan Li, Ruth Boxall, N. Reeve, M. Obeidat, J. Zhao, M. Wielscher, S. Weiss, K. Kentistou, J. Cook, B. Sun, Jian Zhou, J. Hui, S. Karrasch, M. Imboden, S. Harris, J. Marten, Stefan Enroth, S. Kerr, I. Surakka, V. Vitart, T. Lehtimäki, R. Allen, P. Bakke, T. Beaty, E. Bleecker, Y. Bossé, C. Brandsma, Zhengming Chen, J. Crapo, J. Danesh, D. Demeo, F. Dudbridge, R. Ewert, C. Gieger, A. Gulsvik, A. Hansell, K. Hao, Joshua D Hoffman, J. Hokanson, G. Homuth, Peter K. Joshi, P. Joubert, C. Langenberg, Xuan Li, Liming Li, Kuang Lin, L. Lind, N. Locantore, J. Luan, A. Mahajan, J. Maranville, A. Murray, D. Nickle, R. Packer, M. Parker, Megan L. Paynton, D. Porteous, Dmitry Prokopenko, D. Qiao, R. Rawal, H. Runz, I. Sayers, D. Sin, Blair H. Smith, M. Soler Artigas, D. Sparrow, R. Tal-Singer, P. Timmers, M. van den Berge, J. Whittaker, P. Woodruff, L. Yerges-Armstrong, O. Troyanskaya, O. Raitakari, M. Kähönen, O. Polašek, U. Gyllensten, I. Rudan, I. Deary, N. Probst-Hensch, H. Schulz, A. James, James F. Wilson, B. Stubbe, E. Zeggini, M. Jarvelin, N. Wareham, E. Silverman, C. Hayward, A. Morris, A. Butterworth, R. Scott, R. Walters, D. Meyers, M. Cho, D. Strachan, I. Hall, M. Tobin, L. Wain   +108 more
semanticscholar   +1 more source

Chronic obstructive pulmonary disease: management of chronic disease [PDF]

Medicine, 2012
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, affecting an estimated 3 million people in the UK. The most common cause is tobacco smoke. Patients with COPD experience a high symptom burden, worsened during disease instability (termed exacerbations or ‘lung attacks’), and a multidisciplinary approach should ...
Russell, R, Norcliffe, J, Bafadhel, M
openaire   +4 more sources

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Current GOLD recommendations and its implementation within hospitalised COPD patients in Malta [PDF]

, 2015
In 2012, Global Initiative for Chronic Obstructive Lung Disease (GOLD) revised their classification of Chronic Obstructive Pulmonary Disease patients, incorporating spirometry, symptoms and recent exacerbations.
Bilocca, David, Gauci, Jonathan, Mifsud, Maria, Montefort, Stephen, Yamagata, Kentaro   +4 more
core  

Multi-morbidities are Not a Driving Factor for an Increase of COPD-Related 30-Day Readmission Risk [PDF]

, 2020
Background and Objective: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States. COPD is expensive to treat, whereas the quality of care is difficult to evaluate due to the high prevalence of multi ...
Chukmaitov, Askar, Deng, Yangyang, Lin, Shuo-yu, Xue, Hong   +3 more
core   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Experiences of living with chronic obstructive pulmonary disease [PDF]

, 2016
Background: Chronic obstructive pulmonary disease, COPD, is a chronic, slowly progressive disease of the respiratory system. It is most often caused by smoking or pollution.
Andersson, Madeleine, Anifowoshe Nielsen, Mary   +1 more
core  

Single-inhaler fluticasone furoate/umeclidinium/vilanterol versus fluticasone furoate/vilanterol plus umeclidinium using two inhalers for chronic obstructive pulmonary disease: A randomized non-inferiority study [PDF]

, 2018
Background: Single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) 100/62.5/25 μg has been shown to improve lung function and health status, and reduce exacerbations, versus budesonide/formoterol in patients with chronic obstructive ...
Birk, Ruby, Brealey, Noushin, Bremner, Peter R, Ismaila, Afisi S, Lipson, David A, Zhu, Chang-Qing   +5 more
core   +2 more sources