Results 61 to 70 of about 6,002,276 (336)

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Nature Genetics, 2019
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are ...
N. Shrine, A. Guyatt, A. Erzurumluoglu, V. Jackson, B. Hobbs, Carl A. Melbourne, C. Batini, K. Fawcett, K. Song, P. Sakornsakolpat, Xingnan Li, Ruth Boxall, N. Reeve, M. Obeidat, J. Zhao, M. Wielscher, S. Weiss, K. Kentistou, J. Cook, Benjamin B. Sun, Jian Zhou, J. Hui, S. Karrasch, M. Imboden, S. Harris, J. Marten, Stefan Enroth, S. Kerr, I. Surakka, V. Vitart, T. Lehtimäki, R. Allen, P. Bakke, T. Beaty, E. Bleecker, Y. Bossé, C. Brandsma, Zhengming Chen, J. Crapo, J. Danesh, D. Demeo, F. Dudbridge, R. Ewert, C. Gieger, A. Gulsvik, A. Hansell, K. Hao, Joshua D Hoffman, J. Hokanson, G. Homuth, P. Joshi, P. Joubert, C. Langenberg, Xuan Li, Liming Li, Kuang Lin, L. Lind, N. Locantore, J. Luan, A. Mahajan, J. Maranville, A. Murray, D. Nickle, R. Packer, M. Parker, Megan L. Paynton, D. Porteous, Dmitry Prokopenko, D. Qiao, R. Rawal, H. Runz, I. Sayers, D. Sin, Blair H. Smith, M. Soler Artigas, D. Sparrow, R. Tal-Singer, P. Timmers, M. van den Berge, J. Whittaker, P. Woodruff, L. Yerges-Armstrong, O. Troyanskaya, O. Raitakari, M. Kähönen, O. Polašek, U. Gyllensten, I. Rudan, I. Deary, N. Probst-Hensch, H. Schulz, A. James, James F. Wilson, B. Stubbe, E. Zeggini, M. Jarvelin, N. Wareham, E. Silverman, C. Hayward, A. Morris, A. Butterworth, R. Scott, R. Walters, D. Meyers, M. Cho, D. Strachan, I. Hall, M. Tobin, L. Wain   +108 more
semanticscholar   +1 more source

Definition, Causes, Pathogenesis, and Consequences of Chronic Obstructive Pulmonary Disease Exacerbations

Clinics in Chest Medicine, 2020
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are episodes of symptom worsening which have significant adverse consequences for patients.
A. Ritchie, J. Wedzicha
semanticscholar   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Osteoporosis in COPD patients: Risk factors and pulmonary rehabilitation

The Clinical Respiratory Journal, 2022
Objectives To present a review on the pathogenesis, risk factor and treatment of chronic obstructive pulmonary disease complicated with osteoporosis and provide new ideas for the diagnosis and treatment.
Yujuan Li, Hongchang Gao, Lei Zhao, Jinrui Wang   +3 more
doaj   +1 more source

Chronic obstructive pulmonary disease: management of chronic disease [PDF]

Medicine, 2012
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, affecting an estimated 3 million people in the UK. The most common cause is tobacco smoke. Patients with COPD experience a high symptom burden, worsened during disease instability (termed exacerbations or ‘lung attacks’), and a multidisciplinary approach should ...
Russell, R, Norcliffe, J, Bafadhel, M
openaire   +4 more sources

Telehealthcare for chronic obstructive pulmonary disease [PDF]

, 2011
Background Chronic obstructive pulmonary disease (COPD) is a disease of irreversible airways obstruction in which patients often suffer exacerbations. Sometimes these exacerbations need hospital care: telehealthcare has the potential to reduce admission ...
McLean, Susannah, Joseph LY Liu, Ulugbek Nurmatov, Aziz Sheikh, Car, Josip, Susannah McLean, McLean, S., Car, J., Nurmatov, Ulugbek, Sheikh, A., Josip Car, Pagliari, C., Liu, Joseph L. Y., Claudia Pagliari, Liu, J., Pagliari, Claudia, Sheikh, Aziz   +16 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effect of inspiratory pressure support on exercise performance in patients with chronic obstructive pulmonary disease [PDF]

, 2006
Title: Effect of inspiratory pressure support on exercise performance in patients with chronic obstructive pulmonary disease. Purpose: This study examined the effects of a non-invasive ventilator on submaximal and maximal exercise performance in ...
Doggett, Anita
core   +2 more sources

Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial [PDF]

, 2010
Background Acute exacerbations contribute to the morbidity and mortality associated with chronic obstructive pulmonary disease (COPD). This proof-of-concept study evaluates whether intermittent pulsed moxifloxacin treatment could reduce the frequency of ...
Jones, PW, Badenhorst J., Sethi S., Cukier A., Miravitlles, M, Sethi, S, Clancy L., Marlize Schmitt Theron, Bitter-Suermann S., Miravitlles Marc, Bettendorf A., Nadar R., Sanjay Sethi, Queguiner A., Rubinstein, E, Potena A., Naude G., PULSE Study group, Abenhaim N., Schroder-Babo W., Di Bartolo C., null null, Theron, MS, Kroemer B., Ferreyra R., del Campo F., de Oliveira J. A., Wedzicha J. A., Jones P. W., Killian J., Watz H., Millar A., Toubis M., Jadwiga A Wedzicha, Molitor S., Anzueto A., Gebhardt R., Groth G., Sanchez R. P., Peraza R. B., Sharafkhaneh A., Bassaris H., Smith C., Wilson Robert, Merida F. C., Fritscher C., Joubert J., Sethi Sanjay, Llamas F. S., Parada M., Alvarez-Sala L., Rubinstein Ethan, Raz P., Cote C., Vlastos F., Legnani D., Richter K., Menendez R., Barnes N. C., Viljoen J., Hasan S., Lalanne G., Wilson, R, Rubinstein E., Rastogi P., Elliott M., Bolio F. T., Fernandez P., Gaines S., Colberg K., Schaberg T., Harari S., Triot P., Monso E., Nieuwoudt G., Westerhausen U., Paul W Jones, Mans W., O'Connell F., Prins M., Dichmann R., Miravitlles M., Taminau D., Raz M., Ignacio J. M., Plautz M., Jones Paul W, Theron M. S., Zeltser D., Habib M., Kawley F., Jardim J. B., Linnhoff A., Weiler Z., Cutillas J. R., Wedzicha Jadwiga A, Robert Wilson, Barros M., Stockley R., Ethan Rubinstein, Wedzicha, JA, Wilson R., Mahutte C. K., Bugnas B., Littner M., Marc Miravitlles, Luna C., Theron Marlize, Hosp H. A., Pozzi E., Groth J., Rubinstein, Ethan, Wilson, Robert, Theron, Marlize S, Jones, Paul W, Sethi, Sanjay, Miravitlles, Marc, the PULSE Study group, Wedzicha, Jadwiga A   +118 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source