Advanced Science, EarlyView.Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee +5 more
wiley +1 more source
Advanced Science, EarlyView.Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami +7 more
wiley +1 more source
Geometry‐Encoded Soft Strain Sensing via Liquid‐Metal Transmission Lines
Advanced Science, EarlyView.This study presents a liquid‐metal transmission‐line strain sensor that achieves intrinsic decoupling by encoding axial elongation into propagation delay. The time‐domain readout remains stable under complex off‐axis. This enables reliable, repeatable, real‐time elongation measurement in dynamic, multiaxial loading environments for wearable electronics,
Zhang Liu +12 more
wiley +1 more source
Macrophage depletion of CMV latently infected donor hearts ameliorates recipient accelerated chronic rejection. [PDF]
Transpl Infect Dis, 2021 Haese NN +7 more
europepmc +1 more source
Brain Network Dynamics of Local and Global Predictive Processing in Aging
Advanced Science, EarlyView.Separation of concurrent whole‐brain networks in source‐reconstructed magnetoencephalography (MEG) data suggests that healthy aging reorganizes, rather than uniformly attenuates, neural responses elicited from hierarchical auditory violations. Enhanced early sensory deviance processing alongside reduced higher‐order cognitive responses suggests a large‐
Mathias Houe Andersen +9 more
wiley +1 more source
ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma
Advanced Science, EarlyView.MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang +5 more
wiley +1 more source
SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer
Advanced Science, EarlyView.Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian +8 more
wiley +1 more source
Editorial: Anti-HLA DSA and Beyond: Deciphering the Immunological Mechanisms Driving Chronic Rejection. [PDF]
Transpl IntCasiraghi F +5 more
europepmc +1 more source
The natural killer cell activating receptor, NKG2D, is critical to antibody-dependent chronic rejection in heart transplantation. [PDF]
Am J Transplant, 2021 Lin CM, Gill RG, Mehrad B.
europepmc +1 more source
A Robust Bio‐Supportive Hydrogel Patch for Full‐Thickness Repair of Gastroesophageal Defects
Advanced Science, EarlyView.Gastroesophageal defect repair remains a formidable clinical challenge plagued by high leakage and life‐threatening complications. We develop a double‐disc, highly crystalline PVA‐based RBS hydrogel patch featuring suture‐free sealing, robust acid/enzyme resistance and mechanical durability.
Xingqi Song +13 more
wiley +1 more source