Results 221 to 230 of about 297,882 (348)

Genetic Engineering Methods in Primary T Cells

Advanced Therapeutics, EarlyView.
Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley   +1 more source

The Lung Microbiome Predicts Mortality and Response to Azithromycin in Lung Transplant Recipients with Chronic Rejection. [PDF]

Am J Respir Crit Care Med
Combs MP, Luth JE, Falkowski NR, Wheeler DS, Walker NM, Erb-Downward JR, Wakeam E, Sjoding MW, Dunlap DG, Admon AJ, Dickson RP, Lama VN.   +11 more
europepmc   +1 more source

IMMUNOMODULATORY FUNCTIONS OF HYALURONATE IN THE LEW-TO-F344 MODEL OF CHRONIC CARDIAC ALLOGRAFT REJECTION

, 1999
A. Knoflach, Colm Magee, Mark Denton, Kjung Soo Kim, Roland Buelow, Wayne W. Hancock, Mohamed H. Sayegh   +6 more
openalex   +1 more source

Engineered RGD‐Treg‐Exos Targeted Delivery of miR‐218‐5p to Activate Mitophagy and Attenuate Podocyte Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
Tregs‐Exos deliver miR‐218‐5p to increase mitophagy in podocytes by inhibiting the TNC/TLR4/SRC/FUNDC1 pathway. RGD‐Treg‐Exos, engineered to express RGD peptides on the membrane surface, bind to integrins on the surface of podocytes and effectively target podocytes for the delivery of miR‐218‐5p, which increases mitophagy and reduces apoptosis in ...
Zhaochen Guo, Shaohui Gao, Ziyue Wang, Zige Chen, Jinglei Chen, Aiping Duan, Feng Xu, Qinger Wang, Weisong Qin, Caihong Zeng, Zhihong Liu, Hao Bao   +11 more
wiley   +1 more source

Concurrent abnormal non-acid reflux is associated with additional chronic rejection risk in lung transplant patients with increased acid exposure. [PDF]

Dis Esophagus
Lo WK, Muftah M, Goldberg HJ, Sharma N, Chan WW.   +4 more
europepmc   +1 more source

Respiratory viral infection in lung transplantation induces exosomes that trigger chronic rejection. [PDF]

J Heart Lung Transplant, 2020
Gunasekaran M, Bansal S, Ravichandran R, Sharma M, Perincheri S, Rodriguez F, Hachem R, Fisher CE, Limaye AP, Omar A, Smith MA, Bremner RM, Mohanakumar T.   +12 more
europepmc   +1 more source

Rictor Ameliorates Acute Antibody‐Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65‐NLRP3 Axis

Advanced Science, EarlyView.
This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni, Chengcheng Yang, Junqi Zhang, Zhou Hang, Ming Zheng, Dengyuan Feng, Qinghuan Shen, Jinxu Miao, Xulin Sun, Li Sun, Baixin Shen, Min Gu, Zijie Wang   +12 more
wiley   +1 more source

CELL-MEDIATED CYTOTOXICITY: A PREDICTOR OF CHRONIC REJECTION IN PEDIATRIC HLA HAPLOIDENTICAL RENAL TRANSPLANTS1

, 1997
Stephen I. Alexander, Souhad Younes, David Zurakowski, Nadeem M. Mirza, Devendra P. Dubey, Mary Drew, William Harmon, Juan J. Yunis   +7 more
openalex   +1 more source

Risks and benefits of weaning immunosuppression in liver transplant recipients: Long-term follow-up [PDF]

, 1997
Flynn, B, Fung, JJ, Marino, I, Mazariegos, GV, Reyes, J, Starzl, IE   +5 more
core   +1 more source

Human iPSC‐Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

Advanced Science, EarlyView.
Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser, Luz Jovita Dimas‐Harms, Rachel M. Lipman, Jake Inzalaco, Shaughn Bell, Michelle Alcantara, Erikha Valenzuela, George Lawless, Simion Kreimer, Sarah J. Parker, Helen S. Goodridge, Clive N. Svendsen   +11 more
wiley   +1 more source