Results 241 to 250 of about 2,127,841 (292)
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Mechanisms of chronic rejection
Current Opinion in Immunology, 2000Chronic rejection remains the major obstacle to long-term allograft survival. Detailed understanding of putative etiologic risk factors, both antigen-dependent and -independent, is important for designing effective therapeutic strategies to ameliorate this process. Cell senescence may be an important factor in chronic rejection.
A M, Waaga +3 more
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Chronic Rejection in the Heart
2006The dramatic improvements in 1-yr survival following cardiac transplantation have not been matched by similar improvements in long-term graft survival. Long-term survival of allografted hearts is limited by a progressive fibroproliferative disease, resulting in intimal thickening and occlusion of the grafted coronary vessels.
Philip, Hornick, Marlene, Rose
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Chronic Renal Transplant Rejection
American Journal of Kidney Diseases, 1994The most common cause of renal allograft failure, after the first year posttransplant, is chronic rejection (CR). The impact on allograft loss of CR has remained constant despite the improvements in immunosuppression that have occurred. This process is characterized by a gradual decline in graft function over months to years.
S T, Shaikewitz, L, Chan
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Chronic Rejection of the Liver
BioDrugs, 2000Liver transplantation is now widely recognised as an effective treatment option for patients with advanced liver disease. Many units now achieve greater than 85% survival at 1 year, with the majority of patients having a high quality of life. The maintenance of a high quality of life requires careful clinical management to ensure that the continued ...
R F, Garcia, C E, Garcia, P, McMaster
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Lymphoid neogenesis in chronic rejection
Current Opinion in Organ Transplantation, 2008Although chronic rejection is currently one of the main causes of long-term allograft failure, its pathogenesis remains elusive, thereby preventing the development of effective therapy.Recent advances in the comprehension of the pathophysiology of chronic inflammatory diseases could shed new light on the pathogenesis of chronic rejection.
Olivier, Thaunat, Antonino, Nicoletti
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CHRONIC REJECTION OF THE LIVER ALLOGRAFT
Gastroenterology Clinics of North America, 1993Chronic rejection remains one of the major problems in the management of liver transplant recipients. Histologic diagnosis is central to the management of this condition. It remains difficult to predict cases that will progress toward irreversible rejection, because there are no early diagnostic features.
J R, Lowes +2 more
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Chronic allograft rejection: An update
Clinical Transplantation, 1994The etiology of chronic rejection is most probably multifactorial. The common feature in all organ allografts undergoing chronic rejection is persistent perivascular inflammation and a concentric generalized arteriosclerosis affecting all first and second order intramural arteries.
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Chronic rejection ‐ Definition and correlates
Clinical Transplantation, 1994With current immunosuppressive protocols, the incidence of graft loss to acute rejection has been markedly reduced; however, there has been no change in graft loss to chronic rejection. Recently, attention has been focused on the prevention and management of chronic rejection.
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