Results 321 to 330 of about 3,296,949 (379)

Acute and chronic rejection

Seminars in Nephrology, 2001
The major histocompatibility complex molecules are the primary antigens responsible for causing graft rejection, and T-cell recognition of alloantigens is the cardinal event initiating cellular rejection. Current concepts suggest that direct allorecognition mediates acute rejection, whereas indirect allorecognition mediates chronic rejection. In biopsy
A, Tejani, L, Emmett
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Chronic Renal Transplant Rejection

American Journal of Kidney Diseases, 1994
The most common cause of renal allograft failure, after the first year posttransplant, is chronic rejection (CR). The impact on allograft loss of CR has remained constant despite the improvements in immunosuppression that have occurred. This process is characterized by a gradual decline in graft function over months to years.
S T, Shaikewitz, L, Chan
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Mechanisms of chronic rejection

Current Opinion in Immunology, 2000
Chronic rejection remains the major obstacle to long-term allograft survival. Detailed understanding of putative etiologic risk factors, both antigen-dependent and -independent, is important for designing effective therapeutic strategies to ameliorate this process. Cell senescence may be an important factor in chronic rejection.
A M, Waaga, M, Gasser, I, Laskowski, N L, Tilney   +3 more
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The Pathophysiology of Chronic Rejection

The American Journal of the Medical Sciences, 1997
The understanding of chronic rejection has been greatly enhanced by the use of genetically controlled experimental models using inbred rats. Models that express all lesions encountered in human transplants are described. Findings of chronic rejection depend on genetic disparity, strength of the immunologic reaction, response to injury, and perpetuation
R D, Guttmann, R D, Forbes, S X, Zheng
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Lymphoid neogenesis in chronic rejection

Current Opinion in Organ Transplantation, 2008
Although chronic rejection is currently one of the main causes of long-term allograft failure, its pathogenesis remains elusive, thereby preventing the development of effective therapy.Recent advances in the comprehension of the pathophysiology of chronic inflammatory diseases could shed new light on the pathogenesis of chronic rejection.
Olivier, Thaunat, Antonino, Nicoletti
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Chronic Rejection in the Heart

2006
The dramatic improvements in 1-yr survival following cardiac transplantation have not been matched by similar improvements in long-term graft survival. Long-term survival of allografted hearts is limited by a progressive fibroproliferative disease, resulting in intimal thickening and occlusion of the grafted coronary vessels.
Philip, Hornick, Marlene, Rose
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Chronic Allograft Rejection (Obliterative Bronchiolitis)

Seminars in Respiratory and Critical Care Medicine, 2001
Lung and heart-lung transplantation are currently recognized as effective treatment for selected patients with end-stage lung or heart-lung disease. Although the survival rates have improved in recent years, long-term survival is still hampered by the development of chronic rejection.
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Chronic rejection ‐ Definition and correlates

Clinical Transplantation, 1994
With current immunosuppressive protocols, the incidence of graft loss to acute rejection has been markedly reduced; however, there has been no change in graft loss to chronic rejection. Recently, attention has been focused on the prevention and management of chronic rejection.
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Chronic Rejection

Transplantation Proceedings, 1998
N L, Tilney, M, Kusaka, J, Pratschke, M, Wilhelm   +3 more
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Chronic allograft rejection: An update

Clinical Transplantation, 1994
The etiology of chronic rejection is most probably multifactorial. The common feature in all organ allografts undergoing chronic rejection is persistent perivascular inflammation and a concentric generalized arteriosclerosis affecting all first and second order intramural arteries.
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