Results 91 to 100 of about 579,871 (293)

The prognostic value of clinical frailty scale and outcomes in older patients undergoing left ventricular assist device implantation

open access: yesAGING MEDICINE, Volume 5, Issue 4, Page 257-263, December 2022., 2022
The main finding in our study is that Clinical Frailty Scale‐defined frailty status was predictive of 1‐year post‐interventional mortality after left ventricular assist device implantation. Abstract Objectives Heart failure impacts patients’ functional capabilities, ultimately leading to frailty.
Temitope Ajibawo   +3 more
wiley   +1 more source

Heterozygous mutations in factor H aggravate pathological damage in a stable IgA deposition model induced by Lactobacillus casei cell wall extract

open access: yesFrontiers in Immunology
IntroductionActivation of complement through the alternative pathway (AP) has a key role in the pathogenesis of IgA nephropathy (IgAN). We previously showed, by intraperitoneal injection of Lactobacillus casei cell wall extract (LCWE), C57BL/6 mice ...
Jingyi Li   +67 more
doaj   +1 more source

Ammonia Dynamics in the Human Body: Insights in Biomedical Sensing Technologies

open access: yesAdvanced Sensor Research, EarlyView.
Ammonia (NH3) is a significant biomarker in diagnostics, affecting the respiratory system, stomach, liver, kidneys, bladder, and gastrointestinal tract. NH3 detection, using sensors, has the potential to improve medical diagnosis. This review examines recent advancements in NH3 sensing technologies and explores future research directions, including ...
Annelot Nijkoops   +8 more
wiley   +1 more source

Prescription analgesic overuse in older adults: Can we mitigate this growing problem?

open access: yesAGING MEDICINE, Volume 5, Issue 4, Page 294-296, December 2022., 2022
With older adults already on numerous prescription medications to manage their chronic conditions, the addition of pain medications could impose an even greater burden due to dependency issues. We need to understand the use of chronic pain medication, especially opioids, discuss current strategies and gaps, and offer potential solutions to mitigate ...
Sara Kakatkar   +2 more
wiley   +1 more source

Identifying Longitudinal CD4:CD8 Ratio Trajectories Indicative of Chronic Renal Disease Risk among People Living with HIV: An Application of Growth Mixture Models. [PDF]

open access: yesViruses, 2023
Fonseca-Cuevas A   +10 more
europepmc   +1 more source

Inhibition of Aberrant Activated Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism

open access: yesAdvanced Science, EarlyView.
LACK156‐173 is internalized into RA‐FLSs via CAPN2‐mediated endocytosis and inhibits the aggressive phenotype of RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism mediated by overexpressed FASN. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in ...
Jianling Su   +17 more
wiley   +1 more source

A pilot randomized controlled trial of WeiNaoKang (SaiLuoTong) in treating vascular dementia

open access: yesAGING MEDICINE, Volume 5, Issue 4, Page 246-256, December 2022., 2022
A 16‐week randomized double‐blind, placebo‐controlled trial for vascular dementia was carried out with WeiNaoKang (or SaiLuoTong). There were significant differences in improvement in cognitive function and activities of daily living, favouring the treatment group.
Junguang Liu   +6 more
wiley   +1 more source

Effect of Clinical History on Predictive Model Performance for Renal Complications of Diabetes [PDF]

open access: yesarXiv
Diabetes is a chronic disease characterised by a high risk of developing diabetic nephropathy, which, in turn, is the leading cause of end-stage chronic kidney disease. The early identification of individuals at heightened risk of such complications or their exacerbation can be of paramount importance to set a correct course of treatment.
arxiv  

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