Results 41 to 50 of about 579,871 (293)

Deficiency of C3a receptor attenuates the development of diabetic nephropathy

BMJ Open Diabetes Research & Care, 2019
Objective Diabetic nephropathy (DN) is the leading cause of chronic kidney disease and end-stage renal disease. Emerging evidence suggests that complement activation is involved in the pathogenesis of DN.
Ming-hui Zhao, Xiao-Qian Li, Dong-Yuan Chang   +2 more
doaj   +1 more source

Screening of key genes in the pathogenesis of muscle atrophy in CKD-PEW children based on RNA sequencing

BMC Medical Genomics, 2023
Background In children with CKD, Protein Energy Wasting (PEW) is common, which affects the outcome of children and is an important cause of poor prognosis. We are aiming to explore the pathogenesis of muscle wasting in CKD-PEW children.
Liang Ying, Jiang Yeping, Wang Hui, Zhou Nan, FuQian, Shen Ying   +5 more
doaj   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

Molecular Oncology, EarlyView.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang, Anna Schritz, Nikolai Goncharenko, Guy Berchem   +3 more
wiley   +1 more source

Clinical and Pathological Characteristics of Patients With Nonproteinuric Diabetic Nephropathy

Frontiers in Endocrinology, 2021
IntroductionAs the most common complication of diabetes mellitus (DM), diabetic nephropathy (DN) was initially considered to begin with proteinuria preceding the progression of renal insufficiency.
Dong-Yuan Chang, Dong-Yuan Chang, Dong-Yuan Chang, Dong-Yuan Chang, Dong-Yuan Chang, Meng-Rui Li, Meng-Rui Li, Meng-Rui Li, Meng-Rui Li, Meng-Rui Li, Xiao-Juan Yu, Xiao-Juan Yu, Xiao-Juan Yu, Xiao-Juan Yu, Xiao-Juan Yu, Su-Xia Wang, Su-Xia Wang, Su-Xia Wang, Su-Xia Wang, Su-Xia Wang, Min Chen, Min Chen, Min Chen, Min Chen, Min Chen, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao   +29 more
doaj   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Projecting the Burden of Chronic Kidney Disease in a Developed Country and Its Implications on Public Health

International Journal of Nephrology, 2018
Background. Chronic Kidney Disease (CKD) is a major public health problem worldwide. There is limited literature on a model to project the number of people with CKD. This study projects the number of residents with CKD in Singapore by 2035 using a Markov
L. Y. Wong, A. S. T. Liew, W. T. Weng, C. K. Lim, A. Vathsala, M. P. H. S. Toh   +5 more
doaj   +1 more source

Anemia among Chinese patients with chronic kidney disease and its association with quality of life - results from the Chinese cohort study of chronic kidney disease (C-STRIDE)

BMC Nephrology, 2021
Background Anemia is one of the common complications in patients with chronic kidney disease (CKD). However, there is no systematic investigation on the prevalence of anemia in CKD patients and its relationship with the quality of life in China.
Yan Shen, Jinwei Wang, Jing Yuan, Li Yang, Fangfang Yu, Xiaolei Wang, Ming-Hui Zhao, Luxia Zhang, Yan Zha, the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)   +9 more
doaj   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source