Results 61 to 70 of about 3,189 (213)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

SYSTEM FOR PREDICTING THE PROBABILITY OF DEVELOPING RESPIRATORY FAILURE IN CHRONIC MECHANIC BRONCHITIS

Медицина в Кузбассе, 2017
Subject. 433 workers of coal mines of the South of Kuzbass (drifters, stope miners, operators of rock removing machines) were examined at the age of 40 to 54 with a previously established diagnosis of chronic mechanic bronchitis. Objective. To develop a
Николай Иванович Панев, Сергей Николаевич Филимонов, Ольга Юрьевна Коротенко, Роман Николаевич Панев, Наталья Александровна Евсеева, Наталия Яковлевна Панева, Наталья Александровна Ефименко, Фаина Анисимовна Лузина   +7 more
doaj  

Thyroid profile in patients with chronic respiratory failure: effect of domiciliary noninvasive positive airway pressure

Egyptian Journal of Chest Disease and Tuberculosis, 2018
Background Various thyroid hormone states have been described in patients with respiratory failure. Domiciliary noninvasive positive airway pressure (NPAP) can be used for management of chronic respiratory failure.
Maha Yousif, Hany A Hussein, Hany S Rasmy, Yasmin N Elsakhawy   +3 more
doaj   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Long-Term High-Flow Nasal Cannula in Chronic Respiratory Failure in a Patient with Bronchiectasis

Acta Médica Portuguesa
High-flow nasal cannula (HFNC) is a gas delivery system that provides heated and humidified air at higher flow rates than conventional oxygen therapy. While studies on the role of HFNC as a long-term treatment for chronic respiratory failure are limited,
Ana Isabel Santos, Jessica Cemlyn-Jones, Denny Rodrigues   +2 more
doaj   +1 more source

Smarter Sensors Through Machine Learning: Historical Insights and Emerging Trends across Sensor Technologies

Advanced Functional Materials, EarlyView.
This review highlights how machine learning (ML) algorithms are employed to enhance sensor performance, focusing on gas and physical sensors such as haptic and strain devices. By addressing current bottlenecks and enabling simultaneous improvement of multiple metrics, these approaches pave the way toward next‐generation, real‐world sensor applications.
Kichul Lee, Osman Gul, Yeongjae Kwon, Jaeseok Jeong, Seokjoo Cho, Jihyeon Ahn, Jehee Yu, Cheolmin Kim, Donho Lee, Hyeonseok Han, Byeongju Lee, Jungrak Choi, Ji‐Hwan Ha, Yongrok Jeong, Kyungnam Kang, Ali Javey, Junseong Ahn, Inkyu Park   +17 more
wiley   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Treatment of respiratory failure in COPD

International Journal of COPD, 2008
Stephan Budweiser1, Rudolf A Jörres2, Michael Pfeifer1,31Center for Pneumology, Hospital Donaustauf, Donaustauf, Germany; 2Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-University, Munich,
Stephan Budweiser, Rudolf A Jörres, Michael Pfeifer   +2 more
doaj  

Transparent UV‐Curable Self‐Sanitizing Coatings Applicable to Diverse Surfaces and High‐Touch Screens to Mitigate Deadly Pathogen Transmission

Advanced Functional Materials, EarlyView.
Development of a transparent, self‐sanitizing antimicrobial coating technology applicable to a wide range of materials and surfaces‐including touchscreens, transparent substrates, and metal, plastic, and glass‐regardless of pathogen type. The spray‐coated, UV‐cross‐linked imidazole‐based quaternary ammonium chloride materials provide broad‐spectrum ...
Surjith Kumaran, Sumin Han, Euna Oh, Chunghee Jo, Hyerin Shin, Dae‐Hong Ko, Hyo‐Jick Choi   +6 more
wiley   +1 more source

Case Report: Human metapneumovirus infection leading to septic shock in an adult with COPD and morbid obesity

Frontiers in Medicine
BackgroundHuman metapneumovirus (hMPV) is an emerging respiratory pathogen causing illnesses from mild upper respiratory infection to severe pneumonia, particularly in high-risk adults.
Francesco Virzì, Giuseppe Giacopelli, Paolo Tutone, Cecilia Riccobono, Luigi Profera, Santi Maurizio Raineri, Santi Maurizio Raineri, Sandro Tomasello, Giuseppe Accurso   +8 more
doaj   +1 more source