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Autoimmune chronic spontaneous urticaria.
Journal of Allergy and Clinical Immunology, 2022Chronic spontaneous urticaria (CSU) is a debilitating mast cell-driven disease characterized by recurrent wheals and/or angioedema. Substantial progress has been made in dissecting the 2 main autoimmune mechanisms that drive the pathogenesis of CSU. Type
P. Kolkhir +7 more
semanticscholar +3 more sources
Chronic Spontaneous Urticaria: A Review.
JAMAImportance Chronic spontaneous urticaria affects approximately 1% of the general population worldwide, including approximately 3 million people in the US, impairs patients' quality of life, and is associated with multiple comorbidities.
P. Kolkhir +3 more
semanticscholar +3 more sources
Chronic Spontaneous Urticaria: Quality of Life and Economic Impacts.
Immunology and Allergy Clinics of North AmericaThis study focuses on quality of life (QoL) assessment in chronic urticaria, delving into tools, disease-specific measures, and its profound impact. With expanding therapeutic options, understanding QoL becomes crucial.
Levi Keller, Jenny Stitt
semanticscholar +2 more sources
Chronic Spontaneous Urticaria: The Devil's Itch [PDF]
Journal of Allergy and Clinical Immunology: in Practice, 2018 Chronic urticaria is defined as the presence of urticaria for a period exceeding 6 weeks, assuming symptoms for most days of the week. It is divided into chronic inducible urticarias and chronic spontaneous urticaria, previously termed chronic idiopathic urticaria.
Sarbjit Saini, Allen P Kaplan
exaly +3 more sources
2021
Chronic spontaneous urticaria (CSU) is characterized by the rapid and unprompted appearance of itchy weals and/or angio-oedema. Weals are short-lived superficial skin swellings of variable size that are associated with itching or burning (Fig. 6.1). Weals come with flare reactions of the surrounding skin, and they resolve spontaneously (usually within ...
Dorothea Terhorst-Molawi, Marcus Maurer
openaire +1 more source
Chronic spontaneous urticaria (CSU) is characterized by the rapid and unprompted appearance of itchy weals and/or angio-oedema. Weals are short-lived superficial skin swellings of variable size that are associated with itching or burning (Fig. 6.1). Weals come with flare reactions of the surrounding skin, and they resolve spontaneously (usually within ...
Dorothea Terhorst-Molawi, Marcus Maurer
openaire +1 more source
Rilzabrutinib in Antihistamine-Refractory Chronic Spontaneous Urticaria
JAMA dermatologyKey Points Question What is the efficacy and risk profile of rilzabrutinib, an oral reversible covalent Bruton tyrosine kinase inhibitor, in adults with antihistamine-refractory chronic spontaneous urticaria (CSU)?
A. Giménez-Arnau +7 more
semanticscholar +1 more source
Journal of Cutaneous Medicine and Surgery, 2015
Background: Chronic spontaneous urticaria (CSU) is urticaria persisting for more than 6 weeks with no identifiable provoking cause and associated with significant disability. Objectives: The aim of this study was to survey patients ...
Natasha, Gattey +2 more
openaire +2 more sources
Background: Chronic spontaneous urticaria (CSU) is urticaria persisting for more than 6 weeks with no identifiable provoking cause and associated with significant disability. Objectives: The aim of this study was to survey patients ...
Natasha, Gattey +2 more
openaire +2 more sources
The role of eosinophils in chronic spontaneous urticaria
Journal of Allergy and Clinical Immunology, 2020Chronic spontaneous urticaria (CSU) is considered to be primarily a mast cell-driven disease. However, recent evidence suggests that eosinophils may also have an axial role in symptomology. Histologic studies have demonstrated the presence of both eosinophils and eosinophil granules, indicative of activation, in CSU lesions.
Sabine Altrichter +8 more
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Biomarkers of Autoimmune Chronic Spontaneous Urticaria
Current Allergy and Asthma Reports, 2023Chronic spontaneous urticaria and chronic inducible urticaria (CSU/CindU) are caused by mast cell and basophil activation leading to degranulation and the release of histamine and several other mediators. Three kinds of factors can trigger mast cells in CSU: (1) activation of stimulating receptor(s) on the mast cell membrane, (2) upregulation of ...
openaire +2 more sources
Drugs in Development for Chronic Spontaneous Urticaria
Journal of Drugs in Dermatology, 2023Chronic spontaneous urticaria (CSU) is a debilitating disease for which many patients are inadequately treated. However, recent advancements in our understanding of the disease pathophysiology allow us to develop therapies that are more effective for CSU.
William, Nguyen +2 more
openaire +2 more sources