Results 101 to 110 of about 408,452 (313)
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Quality-adjusted survival time without symptoms or toxicity of acalabrutinib with or without obinutuzumab in patients with treatment-naive chronic lymphocytic leukemia [PDF]
, 2023 Jeff P. Sharman +6 more
openalex +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah +7 more
wiley +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Experimental study of chronic toxicity and allergenic properties of the drug afobazol
Фармакокинетика и Фармакодинамика, 2016 The study of chronic toxicity injection form afobazol with daily intravenous administration for 2 weeks old female and male rats in doses of 0,1; 1; 5 and 50 mg/kg, female and male rabbits at doses of 0,1; 1 and 10 mg/kg.
S. V. Alekseeva +4 more
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Chronic gastrointestinal toxicity in gynecology patients treated with intensity-modulated whole pelvic radiation therapy: a preliminary analysis [PDF]
, 2002 Arno J. Mundt +4 more
openalex +1 more source
Chronic Doxepin Toxicity Masquerading as Epilepsy in a 10-Year-Old Boy [PDF]
, 2023 James D. Whitledge +2 more
openalex +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Journal of Experimental PharmacologyAbdul Gafar Victoir Coulidiaty,1 Saamou Isaac Boni,2 Raogo Ouedraogo,1 Benjamin Kouliga Koama,2 Harouna Soré,3 Roland Nâg-Tiero Meda,2 Téné Marceline Yaméogo,4 Estelle Noëla Hoho Youl1 1Laboratoire de Développement du Médicament, Ecole Doctorale Sciences
Coulidiaty AGV +7 more
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