Results 111 to 120 of about 737,090 (311)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Toxicological characteristics of dental gel ‘Matripin’

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2020
We performed toxicological evaluation of dental gel ‘Matripin.’ Objective: to assess acute and chronic toxicity of dental gel ‘Matripin’ on mature rats. Animals were kept in standard vivarium conditions.
L. I. Arystan, M. A. Romanova, D. Dzh. Kauzbaeva, S. T. Tuleutaeva, D. S. Tutay   +4 more
doaj  

Molecular Targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the Zebrafish Ovary: Insights into TCDD-induced Endocrine Disruption and Reproductive Toxicity [PDF]

, 2008
TCDD is a reproductive toxicant and endocrine disruptor, yet the mechanisms by which it causes these reproductive alterations are not fully understood.
Carvan, Michael J., III, Hessner, Martin J., Hutz, Reinhold J., King Heiden, Tisha C., Rise, Matthew L., Struble, Craig   +5 more
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Recreational ketamine use and its impact on health

Journal of Education, Health and Sport
Ketamine, also known as 2-(2-chlorophenyl)-2-(methylamino)-cyclohexanone, is a dissociative anesthetic that has gained popularity as a recreational substance among young people, especially in nightclubs and at parties.
Jakub Perłowski, Marek Miśkiewicz, Jakub Ptak, Rafał Noga, Victoria Teska, Jagoda Marcinkowska, Adrian Herc, Karolina Koczkodon, Marcelina Sawczuk, Mariusz Krompiewski   +9 more
doaj   +1 more source

Mixture toxicity of tebuconazole and fluopyram to honeybee (Apis mellifera L.): Effects on survival, feeding and antioxidant defenses [PDF]

Journal of Plant Protection Research
Tebuconazole + fluopyram is a new binary mixture fungicide product that is widely used to control many plant fungal pathogens and nematodes in several agricultural crops worldwide, including Egypt.
Neama S. Saeed, Sayed A. Ahmed, Zeinab H. Ahmed, Abdulraouf M. Amro, Ibrahim A. Mohamed   +4 more
doaj   +1 more source

Effects of Chronic Waterborne Nickle Exposure on Two Successive Generations of \u3cem\u3eDaphnia Magna\u3c/em\u3e [PDF]

, 2004
In a 21-d chronic toxicity test in which an F0 generation of Daphnia magna were exposed to waterborne Ni, the noobservable-effect concentration (for survival, reproduction, and growth) was 42 μg Ni L-1, or 58% of the measured 21-d median lethal ...
McGeer, James C., Pane, Eric F., Wood, Chris M.   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Flupyradifurone Exhibits Greater Toxicity to the Asian Bumblebee Bombus lantschouensis Compared to the European Bumblebee Bombus terrestris

Insects
Pesticides are considered a major factor in the decline of bee populations. Flupyradifurone, a novel insecticide, is believed to be relatively ‘bee-safe’.
Chunting Jie, Hong Zhang, Ziyu Zhou, Zhengying Miao, Bo Han, Baodi Guo, Yi Guo, Xiao Hu, Shahid Iqbal, Bingshuai Wei, Jiaxing Huang, Pingli Dai, Jiandong An   +12 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source