Results 201 to 210 of about 420,376 (263)
Advanced Healthcare Materials, EarlyView.In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer +12 more
wiley +1 more source
Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment
Advanced Healthcare Materials, EarlyView.Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley +1 more source
Advanced Healthcare Materials, EarlyView.A bicistronic rAAV8 vector encoding Aflibercept (Afb) and COMP‐cAng1 simultaneously coordinates VEGF clearance and Tie2‐mediated vessel maturation. In a 3D angiogenesis‐on‐a‐chip model, rAAV8‐Afb/cAng1 effectively reverses pathological barrier breakdown under clinical disease‐mimicking challenges.
Bong‐Kyu Kim +9 more
wiley +1 more source
Assessment of Acute and Chronic Toxicity in Wistar Rats (Rattus norvegicus) and New Zealand Rabbits (Oryctolagus cuniculus) of an Enriched Polyphenol Extract Obtained from Caesalpinia spinosa. [PDF]
J ToxicolBallesteros-Ramírez R +4 more
europepmc +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Chronic toxicity of Gynostemma pentaphyllum
Fìtoterapìâ, 2004The effect of water extract of Gynostemma pentaphyllum was evaluated on 6-month chronic toxicity in Wistar rats. Control group received orally 10 ml kg(-1) day(-1). The extract was orally given to the five treatment groups at the doses of 6, 30, 150, 750 and 750 mg kg(-1) day(-1) for 24 weeks. The last group served as the recovery group.
A, Attawish +7 more
exaly +3 more sources
Toxicology and Applied Pharmacology, 1965
Abstract The effects of feeding cube powder to rats for two years at dietary levels of 50, 100, 250, 500, and 1000 ppm, and to dogs for 28 months at levels of 50, 150, and 400 ppm have been presented. Cube at all levels, except 50 ppm, inhibited growth of rats. No histopathologic change attributable to cube ingestion was noted at any level.
W H, Hansen, K J, Davis, O G, Fitzhugh
openaire +2 more sources
Abstract The effects of feeding cube powder to rats for two years at dietary levels of 50, 100, 250, 500, and 1000 ppm, and to dogs for 28 months at levels of 50, 150, and 400 ppm have been presented. Cube at all levels, except 50 ppm, inhibited growth of rats. No histopathologic change attributable to cube ingestion was noted at any level.
W H, Hansen, K J, Davis, O G, Fitzhugh
openaire +2 more sources
Automatisation of chronic toxicities
Computer Programs in Biomedicine, 1978Automatisation of collection and processing of chronic toxicity tests are presented in a 'pharmaceutical research center environment'. The data are either analog signals or numerical values transmitted to the computer, from terminals posted in various laboratories.
M, Ageron +3 more
openaire +2 more sources
The acute and chronic toxicities of chlorphenoxamine
Toxicology and Applied Pharmacology, 1962Abstract The acute toxicity of chlorphenoxamine and Keithon were compared in mice and no significant difference was found between the LD50 values or the CD50 values for the two drugs. Chlorphenoxamine was administered for 26 weeks to rats in concentrations of 0.166, 0.249, and 0.374% of the diet without the production of significant pathologic ...
T L, KERLEY +3 more
openaire +2 more sources
Nature, 1965
CERTAIN types of hazard consequent on the administration of chemical substances are estimated by the performance of chronic toxicity tests. Such tests are usually designed according to certain empirical rules. Groups of animals (commonly three) are given a test substance in regularly repeated doses of constant size, each group receiving a different ...
openaire +2 more sources
CERTAIN types of hazard consequent on the administration of chemical substances are estimated by the performance of chronic toxicity tests. Such tests are usually designed according to certain empirical rules. Groups of animals (commonly three) are given a test substance in regularly repeated doses of constant size, each group receiving a different ...
openaire +2 more sources