Results 211 to 220 of about 420,376 (263)

Chronic Toxicity of Polyphenyl Mixtures

American Industrial Hygiene Association Journal, 1965
Abstract In rats the ingestion of Santowax OM, a mixture of terphenyls used as a coolant, and Omre High Boilers over prolonged periods inhibits weight gain and leads to anemia and kidney and liver damage. At a daily dietary intake of 350 mg/kg or more, Santowax OM produces degenerative changes in the nephron; the Omre High Boilers at a daily dietary ...
A, Petkau, J, Hoogstraaten
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Chronic Toxicity of Metrifonate

Acta Pharmacologica et Toxicologica, 1981
Abstract From chronic toxicity studies with metrifonate (identical with trichlorfon) on different animal species, the following conclusion can be reached: 1. There is no conclusive evidence that trichlorfon has a carcinogenic effect. 2. There is no indication that trichlorfon has a significant cumulative toxic effect. 3.
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Chronic toxicity of DMSO in primates

Toxicology and Applied Pharmacology, 1970
Abstract Oral administration or dermal application of pharmaceutical grade DMSO has been evaluated in rhesus monkeys ( Macaca mulatta ) over an 18-month period. Daily doses of 1, 3, or 9 ml/kg body weight of a 90% ( v v ) aqueous DMSO solution were administered topically or intragastrically in equally divided portions each morning and afternoon.
E E, Vogin, S, Carson, G, Cannon, C R, Linegar, L F, Rubin   +4 more
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The chronic toxicity of diphenylamine for dogs

Toxicology and Applied Pharmacology, 1967
Abstract Diphenylamine (DPA), mixed with an adequate diet in concentrations of 0.01, 0.10, and 1.0%, was fed daily to male and female beagles for two years. Growth of both sexes was arrested by the 0.1 and 1.0% diets, the total two-year DPA intakes being, respectively, 0.14 and approximately 1.4 kg per animal.
J O, Thomas, W E, Ribelin, J R, Woodward, F, DeEds   +3 more
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Megacolon: Acute, toxic, and chronic

Current Treatment Options in Gastroenterology, 1999
Megacolon refers to cecal dilatation above the dimension of 12 cm and above 6.5 cm of the sigmoid colon, measured at the pelvic brim. Dilatation of the colon can be broadly categorized into three clinical entities: In acute megacolon (Ogilvie's syndrome), colonic dilatation is attributed to a sympathetically mediated reflex response to a number of ...
, Bharucha, , Phillips
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Chronic toxicity of photomirex in the rat

Toxicology and Applied Pharmacology, 1981
Photomirex (8-monohydromirex) was fed to rats for 21 months at dietary levels of 0, 0.2, 1.0, 5.0, 25, and 125 ppm. All 10 rats fed the 125-ppm diet died during the experiment and decreased body weight was noted preceding death. Body weight gain and food consumption were not affected by photomirex at levels up to and including 25 ppm.
I, Chu, D C, Villeneuve, V E, Valli, V E, Secours, G C, Becking   +4 more
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Acute and Chronic Fluoride Toxicity

Journal of Dental Research, 1992
Compared with the latter half of the 19th century and the first half of the 20th century, the frequency of fatalities stemming from the ingestion of fluoride compounds has declined dramatically. Since 1978, there have been four fatalities caused by the ingestion of fluoride, all in dental products.
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Gadolinium Deposition and Chronic Toxicity

Magnetic Resonance Imaging Clinics of North America, 2017
Clinicians, radiologists, and patients should be aware of the most up-to-date data on the risks of gadolinium-based contrast agent (GBCA) administration. In this review, we discuss in vivo gadolinium retention, particularly brain tissue retention, and potential toxic effects. GBCA pharmacokinetics and biodistribution are reviewed briefly.
Joana, Ramalho, Miguel, Ramalho
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Modeling Oral Rat Chronic Toxicity

Journal of Chemical Information and Modeling, 2008
The chronic toxicity is fundamental for toxicological risk assessment, but its correlation with the chemical structures has been studied only little. This is partly due to the complexity of such an experimental test that embraces a plethora of different biological effects and mechanisms of action, making (Q)SAR studies extremely challenging.
Paolo Mazzatorta, Manuel Dominguez Estevez, Myriam Coulet, Benoît Schilter   +3 more
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The acute and chronic toxicities of nivalenol in mice

Fundamental and Applied Toxicology, 1988
In an attempt to ascertain precisely the toxic effects of nivalenol (NIV), we conducted the determination of LD50 values, and interim kills during the carcinogenic study in mice. LD50 values (mg/kg) of NIV in 6-week-old male ddY mice were determined as 38.9 (po), 7.4 (ip), 7.2 (sc), and 7.3 (iv).
J C, Ryu, K, Ohtsubo, N, Izumiyama, K, Nakamura, T, Tanaka, H, Yamamura, Y, Ueno   +6 more
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