Results 21 to 30 of about 420,376 (263)

Study of chronic toxicity of the GB-115 drug formulation

Фармакокинетика и Фармакодинамика, 2020
The results of the study of chronic toxicity of the drug formulation of anxiolytic GB-115 are presented. The novel dipeptide in the form of a tablet mass was administered daily orally for 6 months to outbred rats and rabbits of the chinchilla breed at a ...
A. V. Sorokina, S. V. Alekseeva, I. A. Miroshkina, V. V. Zabrodina, L. G. Kolik, A. D. Durnev   +5 more
doaj   +1 more source

Durian fruit pulp extract enhances intracellular glutathione levels, mitigating oxidative stress and inflammation for neuroprotection

Scientific Reports
Durian (Durio zibethinus L.) fruit pulp is a rich source of γ-glutamylcysteine (γ-EC), a direct precursor to the antioxidant glutathione (GSH). This study elucidated the in vitro neuroprotective potential of unripe durian fruit pulp extract (UDE) against
Gholamreza Khaksar, Su Lwin Lwin Myint, Hasriadi, Pasarapa Towiwat, Supaart Sirikantaramas, Ratchanee Rodsiri   +5 more
doaj   +1 more source

Study of chronic toxicity of potential anxiolytic Homeovox

Фармакокинетика и Фармакодинамика, 2020
Relevance. Assessment of chronic toxicity is a necessary stage of preclinical research a tablets Homeovox homeopathic. The aim of present research is study of chronic toxicity of a tablets Homeovox homeopathic.Methods. Homeovox was administered orally to
I. A. Miroshkina, A. V. Sorokina, A. V. Volkova, V. V. Zabrodina, K. S. Kachalov, А. D. Zakharov, S. V. Alekseeva, A. S. Lapitskaya   +7 more
doaj   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

Rational Use of Herbal Products in Pediatric Patients Treated With Anticancer Drugs in the European Union

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot, Mathieu Corvaisier, Laurence Spiesser‐Robelet, Mylène Duplan, Isabelle Pellier, Delphine Bourneau‐Martin, Séverine Derbré   +6 more
wiley   +1 more source

Theoretical Calculation on the Reaction Mechanisms, Kinetics and Toxicity of Acetaminophen Degradation Initiated by Hydroxyl and Sulfate Radicals in the Aqueous Phase

Toxics, 2021
The •OH and SO4•− play a vital role on degrading pharmaceutical contaminants in water. In this paper, theoretical calculations have been used to discuss the degradation mechanisms, kinetics and ecotoxicity of acetaminophen (AAP) initiated by •OH and SO4•−
Mengmeng Xu, Junfang Yao, Simei Sun, Suding Yan, Jingyu Sun   +4 more
doaj   +1 more source

Chronic oral toxicity of tylosin

Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene), 1966
Twenty month feeding studies with tylosin using Wister strain rats were carried out to estimate the toxicity and the safety of this antibiotics as a food additive. A total of 160 albino rats, weighing 80∼115g was used. Five groups of 16 each, equally divided as to sex, were fed diets containing 0.1, 0.01, 0.1, 1.0 and 10.0% of tylosin, repectively, for
Aiso, Kazuyoshi, Kanisawa, Masayoshi, Okamoto, Tatsuya, Okita, Masahiko, Chujo, Tomoko   +4 more
openaire   +3 more sources

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte, Hannah Koch, Olivia A. Coughlin, Jillian R. Bouck, Allie Carter, Seethal A. Jacob   +5 more
wiley   +1 more source

Metal evaluation and ecotoxicological bioassays using Chironomus xanthus in sediments of triângulo mineiro watercourses

Bioscience Journal, 2018
This study aimed to evaluate metal contamination in sediments of the Triângulo Mineiro watercourses and also analyze the toxicity of the sediments using Chironomus xanthus larvae, as test organisms.
Renata de Moura Guimaraes-Souto, Juliano José Corbi, Giuliano Buzá Jacobucci   +2 more
doaj   +1 more source