Results 71 to 80 of about 408,452 (313)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Chronic Low-Dose Phoxim Exposure Impairs Silk Production in Bombyx mori L. (Lepidoptera: Bombycidae) by Disrupting Juvenile Hormone Signaling-Mediated Fibroin Synthesis

Toxics
Phoxim is a pesticide extensively applied in mulberry fields, and residues may persist on leaves even after the recommended pre-harvest interval. However, the potential risks of these residues to Bombyx mori L.
Xinyi Xie, Jiayin Hou, Meng Li, Zhiyu Liu, Mengai He, Chenxi Li, Xiaohua Du, Liezhong Chen   +7 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Chronic Toxicity of Silver Nanoparticles

, 2016
The unique physical and chemical properties of silver nanoparticles make them excellent candidates for a variety of purposes in various fields, but the rhythm of using nanoscale materials is rapidly growing and possible ecotoxicological effects, are still unrated exactly.
Pavlovschi, I., Goncear, V.I., Scutari, C.   +2 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Toxicological characteristics of dental gel ‘Matripin’

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2020
We performed toxicological evaluation of dental gel ‘Matripin.’ Objective: to assess acute and chronic toxicity of dental gel ‘Matripin’ on mature rats. Animals were kept in standard vivarium conditions.
L. I. Arystan, M. A. Romanova, D. Dzh. Kauzbaeva, S. T. Tuleutaeva, D. S. Tutay   +4 more
doaj  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Recreational ketamine use and its impact on health

Journal of Education, Health and Sport
Ketamine, also known as 2-(2-chlorophenyl)-2-(methylamino)-cyclohexanone, is a dissociative anesthetic that has gained popularity as a recreational substance among young people, especially in nightclubs and at parties.
Jakub Perłowski, Marek Miśkiewicz, Jakub Ptak, Rafał Noga, Victoria Teska, Jagoda Marcinkowska, Adrian Herc, Karolina Koczkodon, Marcelina Sawczuk, Mariusz Krompiewski   +9 more
doaj   +1 more source

Mixture toxicity of tebuconazole and fluopyram to honeybee (Apis mellifera L.): Effects on survival, feeding and antioxidant defenses [PDF]

Journal of Plant Protection Research
Tebuconazole + fluopyram is a new binary mixture fungicide product that is widely used to control many plant fungal pathogens and nematodes in several agricultural crops worldwide, including Egypt.
Neama S. Saeed, Sayed A. Ahmed, Zeinab H. Ahmed, Abdulraouf M. Amro, Ibrahim A. Mohamed   +4 more
doaj   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source