Results 71 to 80 of about 737,090 (311)
Chronic Fluoride Toxicity: Dental Fluorosis [PDF]
, 2011 Dental fluorosis occurs as a result of excess fluoride ingestion during tooth formation. Enamel fluorosis and primary dentin fluorosis can only occur when teeth are forming, and therefore fluoride exposure (as it relates to dental fluorosis) occurs during childhood.
Pamela, DenBesten, Wu, Li
openaire +2 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed [PDF]
, 2017 Peer reviewedPublisher ...
EFSA Panel on Contaminants in the Food Chain (CONTAM)
core +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Rituximab in combination with high-dose methylprednisolone for the treatment of chronic lymphocytic leukemia. [PDF]
, 2009 We observed that high-dose methylprednisolone (HDMP) and rituximab was well tolerated and had promising activity when used in combination to treat patients with fludarabine-refractory chronic lymphocytic leukemia (CLL).
Bole, J +6 more
core
Therapy of pancreatic cancer via an EphA2 receptor-targeted delivery of gemcitabine. [PDF]
, 2016 First line treatment for pancreatic cancer consists of surgical resection, if possible, and a subsequent course of chemotherapy using the nucleoside analogue gemcitabine.
Barile, Elisa +11 more
core +2 more sources
Chronic oral toxicity of tylosin
Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene), 1966 Twenty month feeding studies with tylosin using Wister strain rats were carried out to estimate the toxicity and the safety of this antibiotics as a food additive. A total of 160 albino rats, weighing 80∼115g was used. Five groups of 16 each, equally divided as to sex, were fed diets containing 0.1, 0.01, 0.1, 1.0 and 10.0% of tylosin, repectively, for
K, Aiso +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Study of acute toxicity of potential anxiolytic GML-1
Фармакокинетика и Фармакодинамика, 2019 Relevance. Assessment of chronic toxicity is a necessary stage of preclinical research of a newly synthesized pharmacological substance GML-1 having anxiolytic activity.
I. A. Miroshkina +7 more
doaj +1 more source