Results 171 to 180 of about 1,954,963 (284)

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

Advanced Science, EarlyView.
PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu, Zitian Zheng, Feiran Wang, Huanhuan Luo, Fei Ju, Yucheng Zhu, Zheng Zhou, Jie Sun, Zhenghui Qiu, Xiang Luo, Zhongzheng Jia, Jianquan Wang, Hongjie Huang, Bo Zhang   +13 more
wiley   +1 more source

Innovative femoral vein valve repair combined with deep femoral vein ligation for treatment of chronic venous insufficiency: a case report. [PDF]

J Cardiothorac Surg
Zheng W, Gu Z, Zhao H, Yan C, Zhang J, Zhao L, Wu Y.   +6 more
europepmc   +1 more source

Chronic venous insufficiency

Archives of Physical Medicine and Rehabilitation, 1994
Sanford H. Vernick, Frank D. Shaw
openaire   +1 more source

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

A Systematic Review of the Effectiveness of Assessing Skin Changes for Chronic Venous Insufficiency in People With Dark Skin Tones and the Impact on the Patient Journey and Clinical Care. [PDF]

Int J Vasc Med
Clemett VJ, Geraghty J, Oozageer Gunowa N, Woodward S, Betemariam TA, Edomobi A, Milsom A, Prevost T, John R, Biasi L.   +9 more
europepmc   +1 more source

Physical exercise for the treatment of non-ulcerated chronic venous insufficiency. [PDF]

Cochrane Database Syst Rev, 2023
Araujo DN, Ribeiro CT, Maciel AC, Bruno SS, Fregonezi GA, Dias FA.   +5 more
europepmc   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

A case of right lower limb Clinical Etiological Anatomical Pathophysiological C6 chronic venous insufficiency accompanied by left iliac vein compression syndrome. [PDF]

J Vasc Surg Cases Innov Tech
Liu M, Guo S, Wang L, Zheng L, Zhuang J, Zhang Z.   +5 more
europepmc   +1 more source

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

The association between restless legs syndrome and chronic venous insufficiency: a systematic review. [PDF]

J Med Life
Alyahya MA, Almansour R, Altamimi A, AlAkeel N.   +3 more
europepmc   +1 more source