Results 11 to 20 of about 1,389 (111)

Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications. [PDF]

J Pineal Res
ABSTRACT Gastrointestinal (GI) cancers remain a leading cause of global morbidity and mortality, necessitating novel therapeutic strategies. Melatonin (MEL), an indoleamine with pleiotropic biological activities, has emerged as a promising adjuvant in oncology due to its antiproliferative, proapoptotic, and antioxidant properties.
Gonciarz M, Wiatrak B, Lombard I, Konecki Ł, Sarbinowska J.   +4 more
europepmc   +2 more sources

Registry and survey of circadian rhythm sleep-wake disorder patients

Sleep Medicine: X
Objective: Circadian Sleep Disorders Network has created a registry of circadian rhythm sleep-wake disorder (CRSWD) patients, and a survey of their experiences.
Peter Mansbach, James S.P. Fadden, Lynn McGovern   +2 more
doaj   +1 more source

Chronotherapy for patients with a depressive episode treated in a public outpatient mental healthcare clinic in Norway: protocol for a randomised controlled trial

BMJ Open
Introduction Depression is highly prevalent in outpatients receiving treatment for mental disorders. Treatment as usual (TAU) usually consists of either psychotherapy and/or antidepressant medication and often takes several weeks before clinical effect ...
Stian Lydersen, Håvard Kallestad, Gunnar Morken, Simen Saksvik, Knut Langsrud, Lina Stålesen Ramfjord, Nikolaj Kahn, Joar Øveraas Øveraas Halvorsen, Liv Sigrun Sættem Engvik   +8 more
doaj   +1 more source

Timing is everything: Expert opinion on researching epilepsy rhythms by the ILAE Task Force on Chronobiology

Epilepsia, EarlyView.
Abstract Recurrent seizures, the hallmark of epilepsy, are influenced by rhythms operating over multiple timescales. Chronobiology is the study of biological timing that aims to explain temporal patterns of events like seizures. Fueled by recent advances in genetics, computational modeling, and device engineering, the chronobiology of epilepsy is now a
Maxime O. Baud, Christophe Bernard, Birgit Frauscher, Philippa J. Karoly, Vikram R. Rao   +4 more
wiley   +1 more source

Clock gene dysregulation in epilepsy: A systematic review

Epilepsia Open, EarlyView.
Abstract Objective Epileptic seizures show a rhythmic pattern, being more frequent at particular times of the day (e.g., only occurring during sleep), suggesting a role of the circadian rhythm. Clock genes regulate the circadian rhythm and might be involved in the pathophysiology of epilepsy.
Guilherme Fernandes‐Campos, Arjune Sen, Francesca Panin, Krithika Sundararaman   +3 more
wiley   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Melatonin as an anti-inflammatory hormone bridging migraine relief and cancer immunity enhancement: a literature review

Frontiers in Immunology
Melatonin, once relegated to the circadian periphery, has resurfaced as a pleiotropic immunomodulator capable of quelling neurogenic inflammation while invigorating antitumour defence.
Qian Zhu, Qian Zhu, Jin Yang, Jin Yang, Jieying Zhang, Jieying Zhang, Qian Song, Qian Song, XinXin Zhang, XinXin Zhang, Menghan Li, Menghan Li, Menglong Zhang, Menglong Zhang, Lei Shi, Xiaoli Song   +15 more
doaj   +1 more source

Physical activity and meal timing alignment with chronotype and their associations with glucose metabolism: The Maastricht Study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Little is known about how the alignment between daily behaviours, such as physical activity and eating, and chronotype relates to glucose metabolism. We investigated whether alignment of physical activity and meal timing with chronotype was associated with glycaemic parameters and with prediabetes or type 2 diabetes (T2DM).
Marvin Y. Chong, Joseph Henson, Martijn J. L. Bours, Hans Bosma, Bastiaan E. de Galan, Carla J. H. van der Kallen, Ree M. Meertens, Hans H. C. M. Savelberg, Miranda T. Schram, Matty P. Weijenberg, Thomas Yates, Annemarie Koster, Simone J. P. M. Eussen   +12 more
wiley   +1 more source

CIRCA: Circadian inference of rhythmicity using comparative analysis from non-invasive continuous measurements of cortisol and melatonin in passive perspiration

Biosensors and Bioelectronics: X
Cortisol and melatonin exhibit distinct circadian rhythms crucial for the regulation of stress and sleep-wake cycles. Precise and continuous evaluation of differential rhythmicity is essential for understanding and managing circadian health; however ...
Annapoorna Ramasubramanya, Preeti Singh, Kai-Chun Lin, Shalini Prasad, Sriram Muthukumar   +4 more
doaj   +1 more source

Waning light, waxing pain: The lunar cycle's association with migraine headache occurrence

Headache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary While migraine headaches can be hard to predict, some patients believe headaches are connected to the moon‘s phases. Our research showed that migraine attacks were 34% more likely to occur during the new moon than during the full moon.
Alexander Yoo, Brendan Keenan, Angeliki Vgontzas, Murray A. Mittleman, Suzanne M. Bertisch, Ron Anafi   +5 more
wiley   +1 more source