Results 21 to 30 of about 1,389 (111)

Regulation of Circadian Rhythm Disruption in Mice via Transcranial Low-Intensity Focused Ultrasound Stimulation Targeting the Suprachiasmatic Nucleus

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Circadian rhythm disruption (CRD) is a critical contributor to sleep, metabolic, and neuropsychiatric disorders. Ultrasound (US) stimulation represents a non-invasive neuromodulatory modality, yet its impact on CRD remains unexplored.
Haiqin Wang, Dapeng Li, Mengke Wang, Baochen Zhang, Zhou Jiang, Yue Wu, Jiawei Duan, Dong Huang, Pengyu Ren, Siyuan Zhang   +9 more
doaj   +1 more source

Arrhythmic expression signatures of circadian clock‐associated transcription factors and chronic circadian disruption contribute to advanced prostate cancer growth

International Journal of Cancer, Volume 158, Issue 3, Page 775-789, 1 February 2026.
What's new? Circadian rhythm disruption potentially fuels prostate cancer progression. The mechanisms and signaling molecules contributing to hormonal tumorigenesis, however, remain largely undefined. In this study, circadian expression patterns of core‐circadian controlled genes (CCCGs) and nuclear receptors (NRs) were investigated in advanced ...
Ria Chopra, Haolong Li, Wenjuan Xie, Daniel Hau Tak Lam, Franky Leung Chan   +4 more
wiley   +1 more source

Timely Questions Emerging in Chronobiology: The Circadian Clock Keeps on Ticking

Journal of Circadian Rhythms
Chronobiology investigations have revealed much about cellular and physiological clockworks but we are far from having a complete mechanistic understanding of the physiological and ecological implications.
Sangeeta Chawla, John O’Neill, Marina I. Knight, Yuqing He, Lei Wang, Erik Maronde, Sergio Gil Rodríguez, Gerben van Ooijen, Eduardo Garbarino-Pico, Eva Wolf, Ouria Dkhissi-Benyahya, Anjoom Nikhat, Shaon Chakrabarti, Shawn D. Youngstedt, Natalie Zi-Ching Mak, Ignacio Provencio, Henrik Oster, Namni Goel, Mario Caba, Maria Oosthuizen, Giles E. Duffield, Christopher Chabot, Seth J. Davis   +22 more
doaj   +1 more source

Efficacy of a Transdiagnostic Sleep and Circadian Intervention for Outpatients With Sleep Problems and Depression, Attention Deficit Disorder, or Bipolar Disorder: A Randomised Controlled Trial

Journal of Sleep Research, Volume 35, Issue 1, February 2026.
ABSTRACT This study aimed to investigate the efficacy of a Danish adaption of a transdiagnostic sleep and circadian intervention, combining cognitive behavioural therapy for insomnia with chronotherapy. A randomised controlled trial enrolling 88 outpatients with depression, attention deficit disorder, or bipolar disorder suffering from insomnia or ...
Mette Kragh, Henny Dyrberg, Sanne Toft Kristiansen, Maria Speed, Pernille Pedersen, Klaus Martiny   +5 more
wiley   +1 more source

The Effect of Chronotherapy on Clinical Outcomes in Hypertensive Patients: A Systematic Review and Meta‐Analysis Comparing Bedtime Versus Morning Dosing of Antihypertensive Drugs

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims This systematic review and meta‐analysis aimed to compare the clinical outcomes of antihypertensive medication administration at bedtime versus morning, focusing on major adverse cardiovascular events (MACE), mortality, and secondary cardiovascular outcomes in hypertensive patients.
Pouria Azami, Alireza Hosseinpour, Ehsan Zandi, Farshad Rajabi, Alireza Mirhosseini, Sarvenaz Farhangdoust, Armin Attar   +6 more
wiley   +1 more source

Predicting acute decompensated heart failure using circadian markers from heart rate time series

ESC Heart Failure, Volume 12, Issue 6, Page 4095-4107, December 2025.
Circadian metrics—amplitude, mesor, and acrophase—derived from a wrist‐worn heart rate monitor can predict acute decompensated heart failure (ADHF) up to 21 days before onset. In 65 post‐ADHF patients, an LSTM model achieved 74% sensitivity, and 73% specificity trained on 21‐day sequences. These findings support circadian rhythm analysis as a promising
Valerie A. A. van Es, Mayke M. C. J. van Leunen, Ignace L. J. de Lathauwer, Cindy C. A. G. Verstappen, René A. Tio, Ruud F. Spee, Lu Yuan, Monica Betta, Giacomo Handjaras, Hareld M. C. Kemps   +9 more
wiley   +1 more source

Inpatient phase-advance therapy for delayed sleep–wake phase disorder: a retrospective study

Nature and Science of Sleep, 2018
Masahiro Takeshima,1 Tetsuo Shimizu,2 Masaru Echizenya,3 Hiroyasu Ishikawa,1,4 Takashi Kanbayashi1 1Department of Neuropsychiatry, Akita University Graduate School of Medicine, Akita, Japan; 2Mental Health and Welfare Center, Akita, Japan; 3Echizenya ...
Takeshima M, Shimizu T, Echizenya M, Ishikawa H, Kanbayashi T   +4 more
doaj  

Progress of non‐motor symptoms in early‐onset Parkinson's disease

Ibrain, Volume 11, Issue 4, Page 422-438, Winter 2025.
This study reviews the research progress related to non‐motor symptoms (NMS) in patients with early onset Parkinson's disease (EOPD), including neuropsychiatric symptoms, autonomic dysfunction, sleep disorders, and sensory disorders and also summarizes the characteristics of NMS in the genetic form of Parkinson's disease (PD).
Fanshi Zhang, Aidi Luo, Shusheng Liao, Mei Liu, Jun Zhang, Zucai Xu   +5 more
wiley   +1 more source

Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer

Nature and Science of Sleep, 2012
Oxana Palesh,1 Luke Peppone,2 Pasquale F Innominato,3–5 Michelle Janelsins,2 Monica Jeong,1 Lisa Sprod,7 Josee Savard,6 Max Rotatori,1 Shelli Kesler,1 Melinda Telli,1 Karen Mustian21Stanford University School of Medicine, Stanford, CA, USA ...
Palesh O, Peppone L, Innominato PF, Janelsins M, Jeong M, Sprod L, Savard J, Rotatori M, Kesler S, Telli M, Mustian K   +10 more
doaj  

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan, Lin Yuan, Ruoyang Zhao, Liting Lu, Yinghao Zhi, Yuying Li, Min Wu, Yongye Huang   +7 more
wiley   +1 more source