Results 31 to 40 of about 1,389 (111)

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang, Xuan Qin, Haiyue Song, Jieru Zhou, Hui Wei, Lun Zhang, Yi Liu, Zhuoqun Wang, Yiren Zhang, Yiwen Lai, Jiayu Yang, Wenting Hu, Zhongshan Chen, Ji Zeng, Yu Jin, Xiaochuan Wang, Rong Liu   +16 more
wiley   +1 more source

Real‐world epilepsy monitoring with ultra‐long‐term subcutaneous electroencephalography: A 15‐month prospective study

Epilepsia, Volume 66, Issue 11, Page 4476-4489, November 2025.
Abstract Objective Novel subcutaneous electroencephalography (sqEEG) systems enable prolonged, near‐continuous cerebral monitoring in real‐world conditions. Nevertheless, the feasibility, acceptability and overall clinical utility of these systems remain unclear. We report on the longest observational study using ultra‐long‐term sqEEG to date.
Pedro F. Viana, Jonas Duun‐Henriksen, Andrea Biondi, Joel S. Winston, Dean R. Freestone, Andreas Schulze‐Bonhage, Benjamin H. Brinkmann, Mark P. Richardson   +7 more
wiley   +1 more source

Acute Myocardial Infarction: Molecular Pathogenesis, Diagnosis, and Clinical Management

MedComm, Volume 6, Issue 10, October 2025.
Key pathogenic mechanisms in AMI. Oxidative stress and mitochondrial dysfunction induce ROS accumulation, while DAMPs‐PRRs interaction triggers inflammatory cascades. Programmed cell death pathways and epigenetic regulation collectively constitute the core components of AMI pathogenesis.
Mengmeng Zhu, Yiwen Li, Qian Xu, Wenting Wang, Yanfei Liu, Yue Liu   +5 more
wiley   +1 more source

Stuck in time: The slow march of circadian medicine and how to speed it up

Journal of Sleep Research, Volume 34, Issue 5, October 2025.
Summary While there is considerable enthusiasm for the translational and clinical applications of chronobiology, their actual implementation is not progressing as rapidly as might be expected. Here we discuss the possibility that this may relate to a combination of conceptual, methodological, evidentiary and training challenges. These are compounded by
Christian Cajochen, Sara Montagnese
wiley   +1 more source

Dreaming of Better Treatments: Advances in Drug Development for Sleep Medicine and Chronotherapy

Journal of Sleep Research, Volume 34, Issue 5, October 2025.
ABSTRACT Throughout history, the development of new sleep medicines has been driven by progress in our understanding of the mechanisms underlying sleep. Ancient civilisations used their understanding of the sedative nature of natural herbs and compounds to induce sleep.
Brooke A. Prakash, Ishani Shah, Guohao Ni, Sridhar Vasudevan, Aarti Jagannath, Russell G. Foster   +5 more
wiley   +1 more source

Cancer Patients Circadian Rhythm Assessment Based on Morningness‐Eveningness Preference: A Cross‐Sectional Study

Health Science Reports, Volume 8, Issue 9, September 2025.
ABSTRACT Background and Aim The circadian rhythm regulates various physiological processes, including sleep‐wake cycle, cell division and cancer development. This study aimed to investigate circadian rhythm patterns in cancer patients. Methods In this cross‐sectional study, 150 cancer patients admitted to the hospital enrolled the study during the fall
Ghazal Daftari, Mahsa Abbaszadeh, Sahar Karimpour Reyhan, Nasim Khajavirad   +3 more
wiley   +1 more source

ADHD as a circadian rhythm disorder: evidence and implications for chronotherapy. [PDF]

Front Psychiatry
Luu B, Fabiano N.
europepmc   +1 more source

Application of circadian rhythm in osteoporosis prevention and treatment: from light, diet, and exercise to chronotherapy. [PDF]

Front Endocrinol (Lausanne)
Qian J, Huang K, Zhai Q.
europepmc   +1 more source

Circadian rhythm disruption and melatonin dysregulation as overlooked drivers of immune imbalance and multiorgan failure in post-COVID syndrome: a call for chronotherapy-based interventions. [PDF]

Ann Med Surg (Lond)
Rizvi GS, Ullah R, Khalid M, Talha M, Waafira A.   +4 more
europepmc   +1 more source