Results 31 to 40 of about 467 (235)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Turning and Churning: Loss of Health Insurance Among Adults in Medicaid [PDF]

Journal of General Internal Medicine, 2008
Having health insurance is good, but keeping it over time is even better. Despite this, millions of Americans experience gaps in their health care coverage. This is a particular concern for non-elderly adults covered by Medicaid, who most commonly lose eligibility due to increases in income or loss of categorical eligibility that they have through ...
Saunders, Milda R., Alexander, G. Caleb
openaire   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

From Churn to Earn: Mitigating Turnover for Better Performance

Encyclopedia
The occurrence of human resource churning results in financial, time and effort losses for organisations, which creates a problem for organisations that lose the most experienced human resources that they have invested in training.
Olga Alexandra Chinita Pirrolas, Pedro Miguel Alves Ribeiro Correia   +1 more
doaj   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Quantifying Dynamic Oil Immersion in a Spiral Bevel Gear via Image Processing for Improved Churning Loss Prediction

Lubricants
This paper investigates the special phenomenon that the practical immersed depth of a spiral bevel gear as the driving gear under splash lubrication is significantly less than the static depth.
Yu Dai, Xin Huang, Jianfeng Zhong, Caihua Yang, Xiang Zhu   +4 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Detailed Investigations on the Oil Flow in Dip-Lubricated Gearboxes by the Finite Volume CFD Method

Lubricants, 2018
Three main concerns are in the focus of the development of geared transmissions nowadays: load carrying capacity, noise–vibration–harshness (NVH) behavior, and efficiency.
Hua Liu, Thomas Jurkschat, Thomas Lohner, Karsten Stahl   +3 more
doaj   +1 more source

Simulation and experimental study of influences of shape of roller on the lubrication performance of precision speed reducer

Engineering Applications of Computational Fluid Mechanics, 2020
This paper presents a study to investigate the effects of the shape of rollers in high precision enveloping speed reducer on the reducer’s lubrication performance. Theoretical models for the precision speed reducer with cylindrical and conical rollers as
Xingqiao Deng, Shisong Wang, Linmao Qian, Yucheng Liu   +3 more
doaj   +1 more source

A model formulation for the prediction of churning power loss in worm gear transmission

Tribology and Materials, 2022
Churning power loss is a complex process that causes significant loss of energy under splash lubrication of gear units. A set of empirical equations are available that allows for precise churning power losses calculation for only the parallel axis gears.
Hardik Chothani, Kalpesh Maniya
openaire   +2 more sources