Results 31 to 40 of about 660 (227)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Rational Design of Spur Gears Directed to Increase Efficiency and Decrease Loss by Friction
Revista Cubana de Ingeniería, 2010 External parallel-axis cylindrical gears are considered as very efficient means for transmitting mechanical power, but for requirements of maximum efficiency in the current machines and equipments a precision in the procedures of calculation of power ...
Gonzalo González Rey +2 more
doaj +1 more source
Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel +8 more
wiley +1 more source
From Churn to Earn: Mitigating Turnover for Better Performance
EncyclopediaThe occurrence of human resource churning results in financial, time and effort losses for organisations, which creates a problem for organisations that lose the most experienced human resources that they have invested in training.
Olga Alexandra Chinita Pirrolas +1 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang +10 more
wiley +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Detailed Investigations on the Oil Flow in Dip-Lubricated Gearboxes by the Finite Volume CFD Method
Lubricants, 2018 Three main concerns are in the focus of the development of geared transmissions nowadays: load carrying capacity, noise–vibration–harshness (NVH) behavior, and efficiency.
Hua Liu +3 more
doaj +1 more source
Engineering Applications of Computational Fluid Mechanics, 2020 This paper presents a study to investigate the effects of the shape of rollers in high precision enveloping speed reducer on the reducer’s lubrication performance. Theoretical models for the precision speed reducer with cylindrical and conical rollers as
Xingqiao Deng +3 more
doaj +1 more source
, 2018 Sufficient oil supply of all machine elements in gearboxes is usually required to avoid damage during operation. Quite frequently, transmissions are conservatively designed with an oversupply of oil to guarantee operational reliability. An oversupply of
Thomas Lohner +6 more
core +1 more source