Results 41 to 50 of about 5,438,556 (275)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Turning and Churning: Loss of Health Insurance Among Adults in Medicaid [PDF]

open access: yesJournal of General Internal Medicine, 2008
Having health insurance is good, but keeping it over time is even better. Despite this, millions of Americans experience gaps in their health care coverage. This is a particular concern for non-elderly adults covered by Medicaid, who most commonly lose eligibility due to increases in income or loss of categorical eligibility that they have through ...
Saunders, Milda R., Alexander, G. Caleb
openaire   +1 more source

Rational Design of Spur Gears Directed to Increase Efficiency and Decrease Loss by Friction

open access: yesRevista Cubana de Ingeniería, 2010
External parallel-axis cylindrical gears are considered as very efficient means for transmitting mechanical power, but for requirements of maximum efficiency in the current machines and equipments a precision in the procedures of calculation of power ...
Gonzalo González Rey   +2 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

open access: yesFEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain   +11 more
wiley   +1 more source

From Churn to Earn: Mitigating Turnover for Better Performance

open access: yesEncyclopedia
The occurrence of human resource churning results in financial, time and effort losses for organisations, which creates a problem for organisations that lose the most experienced human resources that they have invested in training.
Olga Alexandra Chinita Pirrolas   +1 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

About Churning

open access: yes, 2022
The term churn is usually associated to clients, that is, client-based churn, however, this essay focuses on the churning in human resources. Despite its complex and relevant nature, thephenomenon of churning in human resources remains a largely ...
Alexandra Chinita Pirrolas, Olga   +3 more
core   +1 more source

Quantifying Dynamic Oil Immersion in a Spiral Bevel Gear via Image Processing for Improved Churning Loss Prediction

open access: yesLubricants
This paper investigates the special phenomenon that the practical immersed depth of a spiral bevel gear as the driving gear under splash lubrication is significantly less than the static depth.
Yu Dai   +4 more
doaj   +1 more source

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