Oral Protein Therapy for the Future - Transport of Glycolipid-Modified Proteins: Vision or Fiction? [PDF]
, 2010 The reliable and early diagnosis of common complex multifactorial diseases depends on the individual determination of all (or as many as possible) polymorphisms of each susceptibility gene together with amount and type of the corresponding gene products ...
Mueller, Guenter
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Effect of interleukin-6 receptor blockade on surrogates of vascular risk in rheumatoid arthritis: MEASURE, a randomised, placebo-controlled study [PDF]
, 2015 Objectives The interleukin-6 receptor (IL-6R) blocker tocilizumab (TCZ) reduces inflammatory disease activity in rheumatoid arthritis (RA) but elevates lipid concentrations in some patients.
Bathon, Joan M. +10 more
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Journal of Lipid Research, 2009 Recent data suggest that dietary fat promotes intestinal absorption of lipopolysaccharides (LPS) from the gut microflora, which might contribute to various inflammatory disorders.
S. Ghoshal +4 more
semanticscholar +1 more source
Higher chylomicron remnants and LDL particle numbers associate with CD36 SNPs and DNA methylation sites that reduce CD36 [PDF]
, 2016 Cluster of differentiation 36 (CD36) variants influence fasting lipids and risk of metabolic syndrome, but their impact on postprandial lipids, an independent risk factor for cardiovascular disease, is unclear. We determined the effects of SNPs within a ~
Abumrad, Nada A +13 more
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Journal of Veterinary Medical Science, 2013 Chylomicrons from villous columnar epithelial cells are generally known to be transported only by central lymph vessels (CLV), whereas antigenic particulates derived from the intestinal lumen can also be transported by subepithelial blood capillaries ...
E. Takahara +8 more
semanticscholar +1 more source
Postprandial apoE isoform and conformational changes associated with VLDL lipolysis products modulate monocyte inflammation. [PDF]
, 2012 ObjectivePostprandial hyperlipemia, characterized by increased circulating very low-density lipoproteins (VLDL) and circulating lipopolysaccharide (LPS), has been proposed as a mechanism of vascular injury.
Altman, Robin +10 more
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The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium
Human Molecular Genetics, 2012 The uptake and processing of dietary lipids by the small intestine is a multistep process that involves several steps including vesicular and protein transport.
A. Jaschke +12 more
semanticscholar +1 more source
Triglyceride-rich lipoproteins prevent septic death in rats. [PDF]
, 1995 Triglyceride-rich lipoproteins bind and inactive bacterial endotoxin in vitro and prevent death when given before a lethal dose of endotoxin in animals.
Calhoun, MC +6 more
core
Proceedings of the National Academy of Sciences of the United States of America, 1991 Chylomicron catabolism is known to be initiated by the enzyme lipoprotein lipase (triacylglycero-protein acylhydrolase, EC 3.1.1.34). Chylomicron remnants, produced by lipolysis, are rapidly taken up by the liver via an apolipoprotein E (apoE)-mediated ...
U. Beisiegel +2 more
semanticscholar +1 more source
Surface Engineering of Thrombus‐Targeting Nanocarriers for Cardiovascular Diseases: A Short Review
Advanced Materials Interfaces, EarlyView.This paper systematically introduces surface modification strategies for thrombus‐targeting nanocarriers, highlights the clinical significance of nanocarrier‐based thrombolysis therapies, and prospects the synergy of combing thrombolysis and anti‐inflammatory therapies for enhanced therapeutic effect.
Xinyue Ge +7 more
wiley +1 more source