Results 21 to 30 of about 1,353,697 (268)
, 2013 Antes de desenvolver o tema ―Criar ciência‖, propriamente dito, sinto a necessidade de definir alguns termos e de enquadrar alguns conceitos. Em primeiro lugar, este capítulo dedica-se às Ciências ditas Exatas e Naturais, sejam elas de caráter ...
Veiga-Pires, C.
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FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
EDITORES ASSOCIADOS E REVISORES AD HOC
Ciência Florestal, 2010 .
Ciência Florestal
doaj +1 more source
Stock assessment and management of multi-species fisheries:the case study of flatfish fisheries in the portuguese coast [PDF]
, 2009 Tese de doutoramento, Biologia (Biologia Marinha), 2009, Universidade de Lisboa, Faculdade de CiênciasResumo alargado em português disponível no documentoFundação para a Ciência e Tecnologia (FCT), SFRH/BD/19319/2004 and the European Union FEDER ...
Dos santos teixeira, Célia
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Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
, 2007 Artigo de divulgação científica que reflete sobre a relação entre o conhecimento científico e as teses deterministas e ...
Durante Pereira Alves, Daniel
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Comunicação de Ciência - Porquê, como e para quem falar de ciência [PDF]
, 2017 Por que é que os seminários dos cientistas te parecem todos iguais? Quantas vezes assististe a apresentações sobre o que deveria ter sido um tema inspirador, para apenas seres embalado ao ritmo de um tom monocórdico letrado por jargão científico?
Nobre, Alexandra +2 more
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source